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Cancer Causes & Control

, Volume 21, Issue 9, pp 1513–1521 | Cite as

Pickled meat consumption and colorectal cancer (CRC): a case–control study in Newfoundland and Labrador, Canada

  • Josh Squires
  • Barbara Roebothan
  • Sharon Buehler
  • Zhuoyu Sun
  • Michelle Cotterchio
  • Ban Younghusband
  • Elizabeth Dicks
  • John R. Mclaughlin
  • Patrick S. Parfrey
  • Peizhong Peter Wang
Original Paper

Abstract

Objective

Although a large body of epidemiological research suggests that red meat intake increases the risk of colorectal cancer, little is known regarding how such an association varies across populations and types of red meat. The objective of this study was to assess whether an association exists between the intakes of total red meat and pickled red meat and the risk of colorectal cancer in study subjects residing in Newfoundland and Labrador.

Methods

This case–control study of 1,204 residents of Newfoundland and Labrador was part of a larger study on colorectal cancer. Personal history food frequency questionnaires were used to collect retrospective data from 518 individuals diagnosed with colorectal cancer and 686 controls. Intakes were ranked and divided into tertiles. Logistic regression was used to examine the possible association between meat intakes and colorectal cancer diagnosis while controlling for possible confounding factors.

Results

A positive, but non-statistically significant, association between total red meat intake and CRC was observed in this study. Pickled red meat consumption was found to be significantly associated with an increased risk of CRC (men, OR = 2.07, 95% CI 1.37–3.15; women, OR = 2.51, 95% CI 1.45–4.32), the odds ratios increasing with each tertile of consumption, suggesting a dose–response effect.

Conclusion

Intake of pickled red meat appears to increase the risk of colorectal cancer in Newfoundland and Labrador.

Keywords

Colorectal cancer Red meat Pickled meat Newfoundland & Labrador Case–control 

Notes

Acknowledgments

This work was supported by the Canadian Institutes of Health Research Team Grant [CIHR-CPT79845] and Canadian Institutes of Health Research Team in Interdisciplinary Research on Colorectal Cancer Studentship [205835].

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Josh Squires
    • 1
  • Barbara Roebothan
    • 1
  • Sharon Buehler
    • 1
  • Zhuoyu Sun
    • 1
  • Michelle Cotterchio
    • 2
  • Ban Younghusband
    • 4
  • Elizabeth Dicks
    • 4
  • John R. Mclaughlin
    • 3
  • Patrick S. Parfrey
    • 4
  • Peizhong Peter Wang
    • 1
    • 5
  1. 1.Division of Community Health and Humanities, Faculty of MedicineMemorial University of NewfoundlandSt. John’sCanada
  2. 2.Population Studies and SurveillanceCancer Care OntarioTorontoCanada
  3. 3.Samuel Lunenfeld Research InstituteMount Sinai HospitalTorontoCanada
  4. 4.Clinical Epidemiology Unit, Faculty of MedicineMemorial University of NewfoundlandSt. John’sCanada
  5. 5.School of Public HealthTianjin Medical UniversityTianjinChina

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