Cancer Causes & Control

, Volume 21, Issue 8, pp 1227–1236 | Cite as

Age-period-cohort analysis of cancers not related to tobacco, screening, or HIV: sex and race differences

  • Yueh-Ying Han
  • Gregg E. Dinse
  • David M. Umbach
  • Devra L. Davis
  • Joel L. Weissfeld
Original paper

Abstract

Objective

To identify trends in a residual category of cancers not typically associated with tobacco, screening, or human immunodeficiency virus (HIV) infection.

Methods

For persons aged 20–84, we used sex- and race-specific age-period-cohort (APC) models to describe temporal patterns of incidence (1975–2004) and mortality (1970–2004) in the U.S. for a residual cancer category that excluded non-Hodgkin lymphoma, Kaposi sarcoma, and cancer of the oral cavity and pharynx, esophagus, pancreas, larynx, lung and bronchus, urinary bladder, kidney and renal pelvis, colon and rectum, prostate, female breast, and cervix uteri.

Results

Age-specific incidence rose (0.1–0.9% per year, on average) in every sex-race group, with factors related to both time period and birth cohort membership appearing to accelerate the increases in women. Age-specific mortality fell (0.6–0.9% per year, on average) for black and white men and women, with the declines decelerating in white women but accelerating in the other sex-race groups. Extrapolations of APC models predicted higher age-adjusted incidence rates in white women (11%), black women (5%), and white men (4%) in 2005–2009, relative to 2000–2004, and lower rates in black men (−3%), accompanied by lower age-adjusted mortality rates in every sex-race group (−8% in black men, −3% in black women, −1% in white men, and −1% in white women).

Conclusions

The possibility that increased incidence in women over time reflects changes in underlying risks, diagnostic practices, or better case ascertainment should be actively explored. Declining mortality may signify improvements in cancer care.

Keywords

Age-period-cohort model Cancer incidence, Cancer mortality Cancer trends Tobacco Screening HIV SEER Occupational cancer Environmental cancer 

Supplementary material

10552_2010_9550_MOESM1_ESM.doc (180 kb)
Supplementary material 1 (DOC 180 kb)

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Yueh-Ying Han
    • 1
  • Gregg E. Dinse
    • 2
  • David M. Umbach
    • 2
  • Devra L. Davis
    • 3
  • Joel L. Weissfeld
    • 1
    • 4
  1. 1.Department of EpidemiologyUniversity of Pittsburgh Cancer InstitutePittsburghUSA
  2. 2.Biostatistics BranchNational Institute of Environmental Health Sciences, National Institutes of HealthResearch Triangle ParkUSA
  3. 3.Environmental Health TrustMt. Sinai Medical CenterNew YorkUSA
  4. 4.U.P.M.C. Cancer PavilionPittsburghUSA

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