Cancer Causes & Control

, Volume 21, Issue 8, pp 1213–1225

Alcohol intake and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium (PanScan)

  • Dominique S. Michaud
  • Alina Vrieling
  • Li Jiao
  • Julie B. Mendelsohn
  • Emily Steplowski
  • Shannon M. Lynch
  • Jean Wactawski-Wende
  • Alan A. Arslan
  • H. Bas Bueno-de-Mesquita
  • Charles S. Fuchs
  • Myron Gross
  • Kathy Helzlsouer
  • Eric J. Jacobs
  • Andrea LaCroix
  • Gloria Petersen
  • Wei Zheng
  • Naomi Allen
  • Laufey Ammundadottir
  • Manuela M. Bergmann
  • Paolo Boffetta
  • Julie E. Buring
  • Federico Canzian
  • Stephen J. Chanock
  • Françoise Clavel-Chapelon
  • Sandra Clipp
  • Matthew S. Freiberg
  • J. Michael Gaziano
  • Edward L. Giovannucci
  • Susan Hankinson
  • Patricia Hartge
  • Robert N. Hoover
  • F. Allan Hubbell
  • David J. Hunter
  • Amy Hutchinson
  • Kevin Jacobs
  • Charles Kooperberg
  • Peter Kraft
  • Jonas Manjer
  • Carmen Navarro
  • Petra H. M. Peeters
  • Xiao-Ou Shu
  • Victoria Stevens
  • Gilles Thomas
  • Anne Tjønneland
  • Geoffrey S. Tobias
  • Dimitrios Trichopoulos
  • Rosario Tumino
  • Paolo Vineis
  • Jarmo Virtamo
  • Robert Wallace
  • Brian M. Wolpin
  • Kai Yu
  • Anne Zeleniuch-Jacquotte
  • Rachael Z. Stolzenberg-Solomon
Original paper

DOI: 10.1007/s10552-010-9548-z

Cite this article as:
Michaud, D.S., Vrieling, A., Jiao, L. et al. Cancer Causes Control (2010) 21: 1213. doi:10.1007/s10552-010-9548-z

Abstract

The literature has consistently reported no association between low to moderate alcohol consumption and pancreatic cancer; however, a few studies have shown that high levels of intake may increase risk. Most single studies have limited power to detect associations even in the highest alcohol intake categories or to examine associations by alcohol type. We analyzed these associations using 1,530 pancreatic cancer cases and 1,530 controls from the Pancreatic Cancer Cohort Consortium (PanScan) nested case–control study. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using unconditional logistic regression, adjusting for potential confounders. We observed no significant overall association between total alcohol (ethanol) intake and pancreatic cancer risk (OR = 1.38, 95% CI = 0.86–2.23, for 60 or more g/day vs. >0 to <5 g/day). A statistically significant increase in risk was observed among men consuming 45 or more grams of alcohol from liquor per day (OR = 2.23, 95% CI = 1.02–4.87, compared to 0 g/day of alcohol from liquor, P-trend = 0.12), but not among women (OR = 1.35, 95% CI = 0.63–2.87, for 30 or more g/day of alcohol from liquor, compared to none). No associations were noted for wine or beer intake. Overall, no significant increase in risk was observed, but a small effect among heavy drinkers cannot be ruled out.

Keywords

Alcohol Pancreatic cancer Pooled analysis 

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Dominique S. Michaud
    • 1
    • 2
  • Alina Vrieling
    • 3
  • Li Jiao
    • 4
  • Julie B. Mendelsohn
    • 4
  • Emily Steplowski
    • 5
  • Shannon M. Lynch
    • 6
  • Jean Wactawski-Wende
    • 7
  • Alan A. Arslan
    • 8
    • 9
    • 10
  • H. Bas Bueno-de-Mesquita
    • 3
  • Charles S. Fuchs
    • 11
    • 12
  • Myron Gross
    • 13
  • Kathy Helzlsouer
    • 14
  • Eric J. Jacobs
    • 15
  • Andrea LaCroix
    • 16
  • Gloria Petersen
    • 17
  • Wei Zheng
    • 18
  • Naomi Allen
    • 19
  • Laufey Ammundadottir
    • 4
    • 20
  • Manuela M. Bergmann
    • 21
  • Paolo Boffetta
    • 22
    • 23
  • Julie E. Buring
    • 24
    • 25
  • Federico Canzian
    • 26
  • Stephen J. Chanock
    • 4
    • 20
  • Françoise Clavel-Chapelon
    • 27
  • Sandra Clipp
    • 28
  • Matthew S. Freiberg
    • 29
  • J. Michael Gaziano
    • 24
    • 30
  • Edward L. Giovannucci
    • 2
    • 12
    • 31
  • Susan Hankinson
    • 2
    • 12
  • Patricia Hartge
    • 4
  • Robert N. Hoover
    • 4
  • F. Allan Hubbell
    • 32
  • David J. Hunter
    • 2
    • 12
  • Amy Hutchinson
    • 4
    • 33
  • Kevin Jacobs
    • 4
    • 33
    • 34
  • Charles Kooperberg
    • 16
  • Peter Kraft
    • 2
  • Jonas Manjer
    • 35
  • Carmen Navarro
    • 36
    • 37
  • Petra H. M. Peeters
    • 1
    • 38
  • Xiao-Ou Shu
    • 18
  • Victoria Stevens
    • 15
  • Gilles Thomas
    • 4
  • Anne Tjønneland
    • 39
  • Geoffrey S. Tobias
    • 4
  • Dimitrios Trichopoulos
    • 2
    • 40
  • Rosario Tumino
    • 41
  • Paolo Vineis
    • 1
  • Jarmo Virtamo
    • 42
  • Robert Wallace
    • 43
  • Brian M. Wolpin
    • 11
    • 12
  • Kai Yu
    • 4
  • Anne Zeleniuch-Jacquotte
    • 9
    • 10
  • Rachael Z. Stolzenberg-Solomon
    • 4
  1. 1.Division of Epidemiology, Public Health and Primary CareImperial College LondonLondonUK
  2. 2.Department of EpidemiologyHarvard School of Public HealthBostonMA
  3. 3.National Institute for Public Health and the Environment (RIVM)BilthovenThe Netherlands
  4. 4.Division of Cancer Epidemiology and Genetics, National Cancer InstituteNational Institutes of HealthBethesdaUSA
  5. 5.Information Management ServicesSilver SpringUSA
  6. 6.Division of Cancer Control and Population ScienceNational Cancer Institute, National Institutes of HealthBethesdaUSA
  7. 7.Department of Social and Preventive MedicineUniversity at BuffaloSuny, BuffaloUSA
  8. 8.Department of Obstetrics and GynecologyNew York University School of MedicineNew YorkUSA
  9. 9.Department of Environmental MedicineNew York University School of MedicineNew YorkUSA
  10. 10.NYU Cancer InstituteNew YorkUSA
  11. 11.Department of Medical OncologyDana-Farber Cancer InstituteBostonUSA
  12. 12.Channing Laboratory, Department of Medicine, Brigham and Women’s HospitalHarvard Medical SchoolBostonUSA
  13. 13.Department of Laboratory Medicine/Pathology, School of MedicineUniversity of MinnesotaMinneapolisUSA
  14. 14.Prevention and Research CenterMercy Medical CenterBaltimoreUSA
  15. 15.Department of EpidemiologyAmerican Cancer SocietyAtlantaUSA
  16. 16.Division of Public Health SciencesFred Hutchinson Cancer Research CenterSeattleUSA
  17. 17.Department of Health Sciences ResearchMayo ClinicRochesterUSA
  18. 18.Department of Medicine and Vanderbilt-Ingram Cancer CenterVanderbilt UniversityNashvilleUSA
  19. 19.Cancer Epidemiology UnitUniversity of OxfordOxfordUK
  20. 20.Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, Department of Health and Human ServicesNational Cancer Institute, National Institutes of HealthBethesdaMDUSA
  21. 21.Department of EpidemiologyGerman Institute of Human NutritionPotsdam-RehbrückeGermany
  22. 22.International Agency for Research on CancerLyonFrance
  23. 23.The Tisch Cancer Institute, Mount Sinai School of MedicineNew YorkUSA
  24. 24.Divisions of Preventive Medicine and Aging, Department of MedicineBrigham and Women’s Hospital and Harvard Medical SchoolBostonUSA
  25. 25.Department of Ambulatory Care and PreventionHarvard Medical SchoolBostonMAUSA
  26. 26.Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)HeidelbergGermany
  27. 27.Inserm (Institut National de la Santé et de la Recherche Médicale) and Institut Gustave RoussyVillejuifFrance
  28. 28.Johns Hopkins Bloomberg School of Public Health, George W. Comstock Center for Public Health Research and PreventionHagerstownUSA
  29. 29.Center for Research on Health CareUniversity of PittsburghPittsburghUSA
  30. 30.Massachusetts Veterans Epidemiology Research and Information CenterVeterans Affairs Boston Healthcare SystemBostonUSA
  31. 31.Department of NutritionHarvard School of Public HealthBostonUSA
  32. 32.School of MedicineUniversity of CaliforniaIrvineUSA
  33. 33.Core Genotyping Facility, Advanced Technology Program, SAIC-Frederick Inc., NCI-FrederickFrederickUSA
  34. 34.Bioinformed Consulting ServicesGaithersburgUSA
  35. 35.Department of SurgeryMalmö University HospitalMalmöSweden
  36. 36.Department of EpidemiologyMurcia Regional Health CouncilMurciaSpain
  37. 37.CIBER Epidemiología y Salud Pública (CIBERESP)BarcelonaSpain
  38. 38.Julius Center for Health Sciences and Primary CareUniversity Medical Center UtrechtUtrechtThe Netherlands
  39. 39.Department of Diet, Cancer and Health, Institute of Cancer EpidemiologyDanish Cancer SocietyCopenhagenDenmark
  40. 40.Department of Hygiene and EpidemiologyUniversity of Athens Medical SchoolAthensGreece
  41. 41.Cancer Registry and Histopathology Department“Civile-M.P.Arezzo” HospitalRagusaItaly
  42. 42.Department of Chronic Disease PreventionNational Institute for Health and WelfareHelsinkiFinland
  43. 43.Departments of Epidemiology and Internal MedicineUniversity of Iowa Colleges of Public Health and MedicineIowa CityUSA

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