Cancer Causes & Control

, Volume 21, Issue 8, pp 1165–1170

Interleukin-22 genetic polymorphisms and risk of colon cancer

  • Cheryl L. Thompson
  • Sarah J. Plummer
  • Thomas C. Tucker
  • Graham Casey
  • Li Li
Original paper

Abstract

Interleukin-22 (IL-22) is a member of the IL-10 family of anti-inflammatory cytokines that mediates epithelial immunity. IL-22 expression is enhanced in inflamed colon mucosa in individuals with inflammatory bowel disease. We carried out an association study to examine the hypothesis that common variation in the IL-22 gene is associated with risk of colon cancer. Seven tagging SNPs were genotyped in 561 colon cancer cases and 722 population controls. Information on lifestyle risk factors was collected via a self-administered questionnaire. The rs1179251 SNP conferred an estimated odds ratio (OR) of 1.46 (95% CI = 1.04–2.05) and 2.10 (95% CI = 0.66–6.66), respectively, for those heterozygous and homozygous for the G variant (padditive = 0.013) after adjustment for age, gender, and race; the OR assuming a dominant model was 1.50 (95% CI = 1.05–2.08, pdominant = 0.016). No other SNP was statistically significantly associated with colon cancer risk. Haplotype analysis found that one haplotype containing the rs1179251 G allele gave an estimated 52% increase in risk of colon cancer for individuals with at least one copy (OR = 1.52, 95% CI = 1.12–2.06, p = 0.0073). Our findings suggest that the rs1179251 SNP in IL-22 is associated with risk of colon cancer.

Keywords

IL-22 Colon cancer SNP Association Case–control study 

Supplementary material

10552_2010_9542_MOESM1_ESM.doc (112 kb)
Supplementary material 1 (DOC 112 kb)

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Cheryl L. Thompson
    • 1
    • 2
  • Sarah J. Plummer
    • 3
  • Thomas C. Tucker
    • 4
  • Graham Casey
    • 2
    • 3
  • Li Li
    • 1
    • 2
  1. 1.Department of Family Medicine-Research DivisionCase Western Reserve University/University Hospitals of ClevelandClevelandUSA
  2. 2.Case Center for Transdisciplinary Research on Energetics and CancerClevelandUSA
  3. 3.Department of Preventive MedicineUniversity of Southern CaliforniaLos AngelesUSA
  4. 4.Cancer Control Program, University of KentuckyLexingtonUSA

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