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Cancer Causes & Control

, Volume 21, Issue 6, pp 909–917 | Cite as

Body size and risk of prostate cancer in Jamaican men

  • Maria D. Jackson
  • Susan P. Walker
  • Candace M. Simpson
  • Norma McFarlane-Anderson
  • Franklyn I. Bennett
  • Kathleen C. M. Coard
  • William D. Aiken
  • Trevor Tulloch
  • Tomlin J. Paul
  • Robert L. Wan
Original paper

Abstract

We investigated the associations between body size and risk of prostate cancer in a hospital-based case–control study in Jamaica. Height, weight, waist, and hip circumference were measured at enrollment, and data collected on medical and lifestyle factors for newly diagnosed cases (n = 243) and controls (n = 275). Compared with men in the normal range of waist-hip ratio (WHR), men with WHR ≥0.95 were at greater risk of total prostate cancer (OR,1.72; CI, 1.01–3.00) and high-grade cancer (OR, 2.02; CI, 1.03–3.96). With additional control for BMI, the association with WHR remained significant for total prostate cancer (OR, 1.90; CI, 1.01–3.53) and high-grade disease (OR, 2.94; CI, 1.34–6.38). There was no association between waist circumference and cancer without control for BMI but after controlling for BMI, waist circumference >90 cm (OR, 2.45; CI, 1.01–5.94) and >102 cm (OR, 5.57; CI, 1.43–18.63) showed a dose–response relationship with high-grade disease. Height and BMI were not associated with risk of prostate cancer. Abdominal obesity may be associated with risk of high-grade prostate cancer. Risk may be greater in those with higher abdominal obesity relative to overall size. The results further highlight the importance of investigating relationships by characteristics of the tumor.

Keywords

Prostate cancer Tumor characteristics Body size Blacks 

Notes

Acknowledgments

This work was supported by the National Health Fund and the Planning Institute of Jamaica, Michigan State University and University of the West Indies.

Disclosure of potential conflicts of interest

No potential conflicts of interest to disclose.

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Maria D. Jackson
    • 1
  • Susan P. Walker
    • 2
  • Candace M. Simpson
    • 2
  • Norma McFarlane-Anderson
    • 3
  • Franklyn I. Bennett
    • 4
  • Kathleen C. M. Coard
    • 4
  • William D. Aiken
    • 5
  • Trevor Tulloch
    • 5
  • Tomlin J. Paul
    • 1
  • Robert L. Wan
    • 6
  1. 1.Department of Community Health and PsychiatryUniversity of the West IndiesKingstonJamaica
  2. 2.Tropical Medicine Research InstituteUniversity of the West IndiesKingstonJamaica
  3. 3.Department of Basic Medical SciencesUniversity of the West IndiesKingstonJamaica
  4. 4.Department of PathologyUniversity of the West IndiesKingstonJamaica
  5. 5.Department of Surgery, Radiology, Anaesthesia, & Intensive CareUniversity of the West IndiesKingstonJamaica
  6. 6.Kingston Public HospitalKingstonJamaica

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