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Cancer Causes & Control

, Volume 21, Issue 4, pp 577–586 | Cite as

Moderate physical activity and breast cancer risk: the effect of menopausal status

  • Angélica Ángeles-Llerenas
  • Carolina Ortega-Olvera
  • Edelmiro Pérez-Rodríguez
  • Jesús Pablo Esparza-Cano
  • Eduardo Lazcano-Ponce
  • Isabelle Romieu
  • Gabriela Torres-MejíaEmail author
Original paper

Abstract

Introduction

It has been suggested that both moderate- and vigorous-intensity physical activity reduces the risk of breast cancer. However, the effect of moderate-intensity physical activity on breast cancer risk has not been consistently evaluated by menopausal status and has not been evaluated in Mexican women.

Objective

To evaluate the effect of moderate-intensity physical activity (h/week and MET-h/week) on the risk of breast cancer by menopausal status in Mexican women.

Methods

A population-based case–control study was conducted in Mexico. One thousand incident cases and 1,074 matched controls to cases by 5 years of age, site and health institution participated in the study. Women provided information on health, diet and physical activity by means of an in-person interview. Anthropometric measurements and blood samples were obtained from all women. A conditional logistic regression model was used to assess this association.

Results

Participating in moderate-intensity physical activity decreased the risk of BC in both pre- and postmenopausal women (OR = 0.96; 95% CI 0.92.–0.99; OR = 0.90; 95% CI 0.86–0.93, respectively) for every 3 h per week of moderate-intensity physical activity. There was a statistically significant modification effect by menopausal status (p = 0.009).

Conclusions

Strategies need to be identified that will engage women in physical activity programs.

Keywords

Physical activity Mexican women Breast cancer 

Notes

Acknowledgments

We would like to recognize CONACyT for the financial support provided for this work and all physicians responsible for the project in the different participating hospitals: Dr. Germán Castelazo (IMSS, Ciudad de México, DF), Dr. Sinhué Barroso Bravo (IMSS, Ciudad de México, DF), Dr. Fernando Mainero Ratchelous (IMSS, Ciudad de México, DF), Dr. Joaquín Zarco Méndez (ISSSTE, Ciudad de México, DF), Dr. Edelmiro Pérez Rodríguez (Hospital Universitario, Monterrey, Nuevo León), Dr. Jesús Pablo Esparza Cano (IMSS, Monterrey, Nuevo León), Dr. Heriberto Fabela (IMSS, Monterrey, Nuevo León), Dr. Fausto Hernández Morales (ISSSTE, Veracruz, Veracruz), Dr. Pedro Coronel Brizio (CECAN SS, Xalapa, Veracruz) and Dr. Vicente A. Saldaña Quiroz (IMSS, Veracruz, Veracruz).

References

  1. 1.
    World Cancer Research Fund/American Institute for Cancer Research (2007) Food, nutrition, physical activity, and the prevention of cancer: a global perspective. AICR, Washington DCGoogle Scholar
  2. 2.
    Friedenreich CM, Orenstein MR (2002) Physical activity and cancer prevention: etiologic evidence and biological mechanisms. J Nutr 132(11 Suppl):3456S–3464SPubMedGoogle Scholar
  3. 3.
    Lee IM (2003) Physical activity and cancer prevention: data from epidemiologic studies. Med Sci Sports Exerc 35:1823–1827CrossRefPubMedGoogle Scholar
  4. 4.
    Tehard B, Friedenreich CM, Oppert JM, Clavel-Chapelon F (2006) Effect of physical activity on women at increased risk of breast cancer: results from the E3N cohort study. Cancer Epidemiol Biomark Prev 15:57–64CrossRefGoogle Scholar
  5. 5.
    Friedenreich CM, Cust AE (2008) Physical activity and breast cancer risk: impact of timing, type and dose of activity and population subgroup effects. Br J Sports Med 42:636–647CrossRefPubMedGoogle Scholar
  6. 6.
    John EM, Horn-Ross P, Koo J (2003) Lifetime physical activity and breast cancer risk in a multiethnic population: the San Francisco Bay area breast cancer study. Cancer Epidemiol Biomark Prev 12:1143–1152Google Scholar
  7. 7.
    Begum P, Richardson CE, Carmichael AR (2009) Obesity in post menopausal women with a family history of breast cancer: prevalence and risk awareness. Int Semin Surg Oncol 6:1CrossRefPubMedGoogle Scholar
  8. 8.
    Ainsworth BE, Haskell WL, Whitt MC et al (2000) Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc 32(9 Suppl):S498–S504PubMedGoogle Scholar
  9. 9.
    Hernandez B, de Haene J, Barquera S et al (2003) Factors associated with physical activity among Mexican women of childbearing age. Rev Panam Salud Publica 144:235–245Google Scholar
  10. 10.
    Steindorf K, Schmidt M, Kropp S, Chang-Claude J (2003) Case-control study of physical activity and breast cancer risk among premenopausal women in Germany. Am J Epidemiol 157:121–130CrossRefPubMedGoogle Scholar
  11. 11.
    Bernstein L, Henderson BE, Hanisch R et al (1994) Physical exercise and reduced risk of breast cancer in young women. J Natl Cancer Inst 86:1403–1408CrossRefPubMedGoogle Scholar
  12. 12.
    Levi F, Pasche C, Lucchini F et al (1999) Occupational and leisure time physical activity and the risk of breast cancer. Eur J Cancer 35:775–778CrossRefPubMedGoogle Scholar
  13. 13.
    Hirose K, Tajima K, Hamajima N et al (1995) A large-scale, hospital based case-control study of risk factors of breast cancer according to menopausal status. Jpn J Cancer Res 86:146–154PubMedGoogle Scholar
  14. 14.
    Friedenreich CM (2004) Physical activity and breast cancer risk: the effect of menopausal status. Exerc Sport Sci Rev 32:180–184CrossRefPubMedGoogle Scholar
  15. 15.
    Schmidt ME, Steindorf K, Mutschelknauss E et al (2008) Physical activity and postmenopausal breast cancer: effect modification by breast cancer subtypes and effective periods in life. Cancer Epidemiol Biomark Prev 17:3402–3410CrossRefGoogle Scholar
  16. 16.
    Neilson HK, Friedenreich CM, Brockton NT, Millikan RC (2009) Physical activity and postmenopausal breast cancer: proposed biologic mechanisms and areas for future research. Cancer Epidemiol Biomark Prev 18:11–27CrossRefGoogle Scholar
  17. 17.
    MacDonald PC, Edman CD, Hemsell DL, Porter JC, Siiteri PK (1978) Effect of obesity on conversion of plasma androstenedione to estrone in postmenopausal women with and without endometrial cancer. Am J Obstet Gynecol 130:448–455PubMedGoogle Scholar
  18. 18.
    Cleland WH, Mendelson CR, Simpson ER (1985) Effects of aging and obesity on aromatase activity of human adipose cells. J Clin Endocrinol Metab 60:174–177CrossRefPubMedGoogle Scholar
  19. 19.
    Edman CD, Aiman EJ, Porter JC, MacDonald PC (1978) Identification of the estrogen product of extraglandular aromatization of plasma androstenedione. Am J Obstet Gynecol 130:439–447PubMedGoogle Scholar
  20. 20.
    Willett WC (1998) Nutritional epidemiology, 2nd edn. Oxford University Press, New YorkGoogle Scholar
  21. 21.
    Hernandez-Avila M, Romieu I, Parra S, Hernandez-Avila J, Madrigal H, Willett W (1998) Validity and reproducibility of a food frequency questionnaire to assess dietary intake of women living in Mexico City. Salud Publica Mex 40:133–140PubMedGoogle Scholar
  22. 22.
    Romieu I, Parra S, Hernandez J, Madrigal H, Willett W, Hernandez M (1999) Questionnaire assessments of antioxidants and retinol intakes in Mexican Women. Arch Med Res 30:224–239CrossRefPubMedGoogle Scholar
  23. 23.
    U.S. Department of Agriculture, Agricultural Research Service (2009) USDA National Nutrient Database for Standard Reference, Release 22. Nutrient Data Laboratory Home Page, http://www.ars.usda.gov/ba/bhnrc/ndl
  24. 24.
    Morales de León J, Babinsky V, Bourges H, Camacho PM (2000) Tables of composition of Mexican foods [Published in CD-ROM Interactive Multimedia]. INCMNSZ, Mexico; ISBN: 968-6499253Google Scholar
  25. 25.
    Sallis JF, Haskell WL, Wood PD et al (1985) Physical activity assessment methodology in the five-city project. Am J Epidemiol 121:91–106PubMedGoogle Scholar
  26. 26.
    Pereira MA, FitzerGerald SJ, Gregg EW et al (1997) A collection of Physical Activity Questionnaires for health-related research. Med Sci Sports Exerc 29(6 Suppl):S1–S205PubMedGoogle Scholar
  27. 27.
    Kolenikov S, Angeles G (2004) The use of discrete data in PCA: theory, simulations, and applications to the socioeconomic indices. University of North Carolina, Chapel HillGoogle Scholar
  28. 28.
    Salazar-Martinez E, Lazcano-Ponce EC, Gonzalez Lira-Lira G, Escudero-De los Rios P, Salmeron-Castro J, Hernandez-Avila M (1999) Reproductive factors of ovarian and endometrial cancer risk in a high fertility population in Mexico. Cancer Res 59:3658–3662PubMedGoogle Scholar
  29. 29.
    Bassol Mayagoitia S (2006) La edad de la menopausia en México. Rev Endocrinol Nutr 14:133–136Google Scholar
  30. 30.
    Ortiz-Rodríguez SP, Torres-Mejía G, Mainero-Ratchelous F et al (2008) Physical activity and breast cancer risk in Mexican women. Salud Publica Mex 50:126–135PubMedGoogle Scholar
  31. 31.
    Landis JR, Koch GG (1977) The measurement of observer agreement for categorical data. Biometrics 33:159–174CrossRefPubMedGoogle Scholar
  32. 32.
    Moradi T, Hans-Olov A, Anders E (2002) Physical activity and risk for breast cancer: a prospective cohort study among Swedish twins. Int J Cancer 100:76–81CrossRefPubMedGoogle Scholar
  33. 33.
    Verloop J, Rookus MA, van der Kooy K, van Leeuwen FE (2000) Physical activity and breast cancer risk in women aged 20–54 years. J Natl Cancer Inst 92:128–135CrossRefPubMedGoogle Scholar
  34. 34.
    Breslow R, Ballard-Barbash R, Muñoz K, Graudard B (2001) Long-term recreational physical activity and breast cancer in the National Health and Nutrition Examination Survey I Epidemiologic follow-up study. Cancer Epidemiol Biomark Prev 10:805–808Google Scholar
  35. 35.
    Friedenreich CM, Courneya K, Briant S (2001) Relation between intensity of physical activity and breast cancer risk reduction. Med Sci Sports Exerc 33:1538–1545CrossRefPubMedGoogle Scholar
  36. 36.
    Thune I, Furberg AS (2001) Physical activity and cancer risk: dose-response and cancer, all sites and site-specific. Med Sci Sports Exerc 33(6 Suppl):S530–S550PubMedGoogle Scholar
  37. 37.
    Vainio H, Kaaks R, Bianchini F (2002) Weight control and physical activity in cancer prevention: international evaluation of the evidence. Eur J Cancer Prev 11:S94–S100PubMedGoogle Scholar
  38. 38.
    McTiernan A, Ulrich C, Slate S, Potter J (1998) Physical activity and cancer etiology: associations and mechanisms. Cancer Causes Control 9:487–509CrossRefPubMedGoogle Scholar
  39. 39.
    Gammon MD, John EM, Britton JA (1998) Recreational and occupational physical activities and risk of breast cancer. J Natl Cancer Inst 90:100–117CrossRefPubMedGoogle Scholar
  40. 40.
    Monninkhof E, Elias S, Vlems F et al (2007) Physical activity and breast cancer: a systematic review of the current evidence. Epidemiology 18:137–157CrossRefPubMedGoogle Scholar
  41. 41.
    Peters TM, Schatzkin A, Gierach GL et al (2009) Physical activity and postmenopausal breast cancer risk in the NIH-AARP diet and health study. Cancer Epidemiol Biomark Prev 18:289–296CrossRefGoogle Scholar
  42. 42.
    Friedenreich CM (2001) Review of anthropometric factors and breast cancer risk. Eur J Cancer Prev 10:15–32CrossRefPubMedGoogle Scholar
  43. 43.
    McTiernan A, Ulrich CM, Yancey D et al (1999) The physical activity for total health (PATH) study: rationale and design. Med Sci Sports Exerc 31:1307–1312CrossRefPubMedGoogle Scholar
  44. 44.
    Irwin ML, Yasui Y, Ulrich CM et al (2003) Effect of moderate- and vigorous intensity exercise on total and intra-abdominal body fat in postmenopausal women: a one-year randomized controlled trial. JAMA 289:323–330CrossRefPubMedGoogle Scholar
  45. 45.
    McTiernan A, Tworoger SS, Ulrich CM et al (2004) Effect of exercise on serum estrogen in postmenopausal women: a 12-month randomized controlled trial. Cancer Res 64:2923–2928CrossRefPubMedGoogle Scholar
  46. 46.
    US Department of Health and Human Services (1996) Physical activity and health: report of the surgeon general. US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, AtlantaGoogle Scholar
  47. 47.
    Slattery M, Sweeney L, Edwards S et al (2006) Physical activity patterns and obesity in Hispanic and non Hispanic white women. Med Sci Sports Exerc 38:33–41CrossRefPubMedGoogle Scholar
  48. 48.
    O’Brien K, Cokkinides V, Jemal A et al (2003) Cancer statistics for Hispanics. CA Cancer J Clin 53:208–226CrossRefPubMedGoogle Scholar
  49. 49.
    Jakicic JM (2000) The role of physical activity in prevention and treatment of body weight gain in adults. J Nutr 132:3826S–3829SGoogle Scholar
  50. 50.
    Physical Activity Guidelines Advisory Committee, US Department of Health and Human Services (2008) Physical activity guidelines advisory committee report, 2008. Washington, D.CGoogle Scholar
  51. 51.
    Pratt M, Jacoby ER, Neiman A (2004) Promoting physical activity in the Americas. Food Nutr Bull 25:183–193PubMedGoogle Scholar
  52. 52.
    Jacoby ER (2004) PAHO regional consultation of the Americas on diet, physical activity and health. Food Nutr Bull 25:172–174PubMedGoogle Scholar
  53. 53.
    Pate RR, Pratt M, Blair SN et al (1995) Physical activity and public health. A recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine. JAMA 273:402–407CrossRefPubMedGoogle Scholar
  54. 54.
    Norman A, Bellocco R, Bergström A, Wolk A (2001) Validity and reproducibility of self-reported total physical activity-differences by relative weight. Int J Obes Relat Metab Disord 25:682–688CrossRefPubMedGoogle Scholar
  55. 55.
    Wolf AM, Hunter DJ, Colditz GA et al (1994) Reproducibility and validity of a self-administered physical activity questionnaire. Int J Epidemiol 23:991–999CrossRefPubMedGoogle Scholar
  56. 56.
    Chasan-Taber L, Erickson JB, Nasca PC, Chasan-Taber S, Freedson PS (2002) Validity and reproducibility of a physical activity questionnaire in women. Med Sci Sports Exerc 34:987–992CrossRefPubMedGoogle Scholar
  57. 57.
    Wiktorin C, Hjelm EW, Winkel J, Köster M (1996) Reproducibility of a questionnaire for assessment of physical load during work and leisure time. Stockholm MUSIC I Study Group. MUSculoskeletal Intervention Center. J Occup Environ Med 38:190–201CrossRefPubMedGoogle Scholar
  58. 58.
    Chasan-Taber S, Rimm EB, Stampfer MJ et al (1996) Reproducibility and validity of a self-administered physical activity questionnaire for male health professionals. Epidemiology 7:81–86CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Angélica Ángeles-Llerenas
    • 1
  • Carolina Ortega-Olvera
    • 1
  • Edelmiro Pérez-Rodríguez
    • 2
  • Jesús Pablo Esparza-Cano
    • 3
  • Eduardo Lazcano-Ponce
    • 1
  • Isabelle Romieu
    • 1
    • 4
  • Gabriela Torres-Mejía
    • 1
    Email author
  1. 1.Instituto Nacional de Salud PúblicaCentro de Investigaciones en Salud PoblacionalCuernavacaMéxico
  2. 2.Hospital UniversitarioMonterreyMéxico
  3. 3.Hospital No. 23 de GinecologíaIMSSMonterreyMéxico
  4. 4.INSERM/ERI 20VillejuifFrance

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