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Cancer Causes & Control

, Volume 21, Issue 3, pp 473–478 | Cite as

A case–control study of reproductive factors, female hormone use, and risk of pancreatic cancer

  • Yuqing ZhangEmail author
  • Patricia F. Coogan
  • Julie R. Palmer
  • Brian L. Strom
  • Lynn Rosenberg
Original paper

Abstract

Findings from several previous studies that have assessed the relation of reproductive factors and female hormone use to the risk of pancreatic cancer are inconclusive. The authors examined the association between reproductive factors and the use of oral contraceptives and postmenopausal hormone therapy to the risk of pancreatic cancer among 284 patients with pancreatic cancer and 1,096 controls using data from the hospital-based Case–Control Surveillance Study. Older age at first pregnancy and long-duration oral contraceptive use were associated with an increased risk of pancreatic cancer: the odds ratio was 2.0 (95% CI: 1.1–3.3) for first birth at age 30 or older compared with before age 20 (p for trend = 0.042) and 2.0 (95% CI: 1.0–4.0) for ten or more years of use of oral contraceptive use relative to no-use (p for trend < 0.01). Risk of pancreatic cancer risk was not associated with postmenopausal female hormone use. The findings suggest that increased exposure to estrogen during the reproductive years may play a role in the development of pancreatic cancer in women. Further studies are needed to confirm the findings.

Keywords

Pancreatic neoplasm Oral contraceptive Reproductive factors Case–control studies 

References

  1. 1.
    Michaud DS (2004) Epidemiology of pancreatic cancer. Minerva Chir 59:99–111PubMedGoogle Scholar
  2. 2.
    Bourhis J, Lacaine F, Augusti M, Huguier M (1987) Protective effect of oestrogen in pancreatic cancer. Lancet 2:977CrossRefPubMedGoogle Scholar
  3. 3.
    Kvale G, Heuch I, Nilssen S (1994) Parity in relation to mortality and cancer incidence: a prospective study of Norwegian women. Int J Epidemiol 23:691–699CrossRefPubMedGoogle Scholar
  4. 4.
    Heuch I, Jacobsen BK, Albrektsen G, Kvale G (2008) Reproductive factors and pancreatic cancer risk: a Norwegian cohort study. Br J Cancer 98:189–193CrossRefPubMedGoogle Scholar
  5. 5.
    Lo AC, Soliman AS, El-Ghawalby N et al (2007) Lifestyle, occupational, and reproductive factors in relation to pancreatic cancer risk. Pancreas 35:120–129CrossRefPubMedGoogle Scholar
  6. 6.
    Rosenblatt KA, Gao DL, Ray RM et al (2006) Induced abortions and the risk of all cancers combined and site-specific cancers in Shanghai. Cancer Causes Control 17:1275–1280CrossRefPubMedGoogle Scholar
  7. 7.
    Lin Y, Kikuchi S, Tamakoshi A et al (2006) Association of menstrual and reproductive factors with pancreatic cancer risk in women: findings of the Japan Collaborative Cohort Study for Evaluation of Cancer Risk. J Gastroenterol 41:878–883CrossRefPubMedGoogle Scholar
  8. 8.
    Teras LR, Patel AV, Rodriguez C, Thun MJ, Calle EE (2005) Parity, other reproductive factors, and risk of pancreatic cancer mortality in a large cohort of US women (United States). Cancer Causes Control 16:1035–1040CrossRefPubMedGoogle Scholar
  9. 9.
    Navarro Silvera SA, Miller AB, Rohan TE (2005) Hormonal and reproductive factors and pancreatic cancer risk: a prospective cohort study. Pancreas 30:369–374CrossRefPubMedGoogle Scholar
  10. 10.
    Duell EJ, Holly EA (2005) Reproductive and menstrual risk factors for pancreatic cancer: a population-based study of San Francisco Bay Area women. Am J Epidemiol 161:741–747CrossRefPubMedGoogle Scholar
  11. 11.
    Skinner HG, Michaud DS, Colditz GA et al (2003) Parity, reproductive factors, and the risk of pancreatic cancer in women. Cancer Epidemiol Biomark Prev 12:433–438Google Scholar
  12. 12.
    Kreiger N, Lacroix J, Sloan M (2001) Hormonal factors and pancreatic cancer in women. Ann Epidemiol 11:563–567CrossRefPubMedGoogle Scholar
  13. 13.
    Karlson BM, Wuu J, Hsieh CC, Lambe M, Ekbom A (1998) Parity and the risk of pancreatic cancer: a nested case-control study. Int J Cancer 77:224–227CrossRefPubMedGoogle Scholar
  14. 14.
    Kalapothaki V, Tzonou A, Hsieh CC, Toupadaki N, Karakatsani A, Trichopoulos D (1993) Tobacco, ethanol, coffee, pancreatitis, diabetes mellitus, and cholelithiasis as risk factors for pancreatic carcinoma. Cancer Causes Control 4:375–382CrossRefPubMedGoogle Scholar
  15. 15.
    Miller AB, Barclay TH, Choi NW et al (1980) A study of cancer, parity and age at first pregnancy. J Chronic Dis 33:595–605CrossRefPubMedGoogle Scholar
  16. 16.
    Bueno de Mesquita HB, Maisonneuve P, Moerman CJ, Walker AM (1992) Anthropometric and reproductive variables and exocrine carcinoma of the pancreas: a population-based case-control study in The Netherlands. Int J Cancer 52:24–29CrossRefPubMedGoogle Scholar
  17. 17.
    Fernandez E, La Vecchia C, D’Avanzo B, Negri E (1995) Menstrual and reproductive factors and pancreatic cancer risk in women. Int J Cancer 62:11–14CrossRefPubMedGoogle Scholar
  18. 18.
    Ji BT, Hatch MC, Chow WH et al (1996) Anthropometric and reproductive factors and the risk of pancreatic cancer: a case-control study in Shanghai, China. Int J Cancer 66:432–437CrossRefPubMedGoogle Scholar
  19. 19.
    Prizment AE, Anderson KE, Hong CP, Folsom AR (2007) Pancreatic cancer incidence in relation to female reproductive factors: Iowa women’s health study. JOP 8:16–27PubMedGoogle Scholar
  20. 20.
    La Vecchia C, Negri E, Franceschi S, Parazzini F (1993) Long-term impact of reproductive factors on cancer risk. Int J Cancer 53:215–219CrossRefPubMedGoogle Scholar
  21. 21.
    Lin RS, Kessler II (1981) A multifactorial model for pancreatic cancer in man. Epidemiologic evidence. JAMA 245:147–152CrossRefPubMedGoogle Scholar
  22. 22.
    Inoue M, Iwasaki M, Otani T, Sasazuki S, Noda M, Tsugane S (2006) Diabetes mellitus and the risk of cancer: results from a large-scale population-based cohort study in Japan. Arch Intern Med 166:1871–1877CrossRefPubMedGoogle Scholar
  23. 23.
    Satake M, Sawai H, Go VL et al (2006) Estrogen receptors in pancreatic tumors. Pancreas 33:119–127CrossRefPubMedGoogle Scholar
  24. 24.
    Sumi C, Longnecker DS, Roebuck BD, Brinck-Johnsen T (1989) Inhibitory effects of estrogen and castration on the early stage of pancreatic carcinogenesis in Fischer rats treated with azaserine. Cancer Res 49:2332–2336PubMedGoogle Scholar
  25. 25.
    Greenway B, Iqbal MJ, Johnson PJ, Williams R (1981) Oestrogen receptor proteins in malignant and fetal pancreas. Br Med J (Clin Res Ed) 283:751–753CrossRefGoogle Scholar
  26. 26.
    Iqbal MJ, Greenway B, Wilkinson ML, Johnson PJ, Williams R (1983) Sex-steroid enzymes, aromatase and 5 alpha-reductase in the pancreas: a comparison of normal adult, foetal and malignant tissue. Clin Sci (Lond) 65:71–75Google Scholar
  27. 27.
    Fyssas I, Syrigos KN, Konstandoulakis MM et al (1997) Sex hormone levels in the serum of patients with pancreatic adenocarcinoma. Horm Metab Res 29:115–118CrossRefPubMedGoogle Scholar
  28. 28.
    Corbishley TP, Iqbal MJ, Wilkinson ML, Williams R (1986) Circulating sex steroids and sex hormone binding globulin in pancreatic adenocarcinoma. Anticancer Res 6:219–222PubMedGoogle Scholar
  29. 29.
    Keating JJ, Johnson PJ, Cochrane AM et al (1989) A prospective randomised controlled trial of tamoxifen and cyproterone acetate in pancreatic carcinoma. Br J Cancer 60:789–792PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Yuqing Zhang
    • 1
    Email author
  • Patricia F. Coogan
    • 2
  • Julie R. Palmer
    • 2
  • Brian L. Strom
    • 3
  • Lynn Rosenberg
    • 2
  1. 1.Clinical Epidemiology Research and Training UnitBoston University School of MedicineBostonUSA
  2. 2.Slone Epidemiology CenterBoston UniversityBostonUSA
  3. 3.Center for Clinical Epidemiology and Biostatistics, Department of Biostatistics and Epidemiology, Center for Education and Research on Therapeutics, and Division of General Internal Medicine of the Department of MedicineUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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