Cancer Causes & Control

, Volume 20, Issue 9, pp 1733–1737

Family history of cancer and risk of breast cancer in the Black Women’s Health Study

  • Julie R. Palmer
  • Deborah A. Boggs
  • Lucile L. Adams-Campbell
  • Lynn Rosenberg
Original paper

Abstract

Introduction

Relatively little research has been conducted on familial breast cancer in African American women.

Methods

Data from the Black Women’s Health Study, a prospective cohort study of African American women, were used to assess breast cancer risk in relation to family history of cancer. Since 1995, participants have completed biennial postal questionnaires on health status, risk factors, and family history of cancer. Cox proportional hazards analyses were used to calculate incidence rate ratios (IRRs) and 95% confidence intervals (CI) for family history of breast and other types of cancer.

Results

Among 57,364 participants who were cancer-free at baseline, 1,306 incident breast cancer cases occurred during 12 years of follow-up. The IRR for a first-degree family history of breast cancer relative to no family history was 1.78 (95% CI 1.55–2.06). IRRs varied by the age at diagnosis, from 1.60 (≥age 55) to 2.76 (<age35). Results were consistent across subtypes of breast tumor defined by estrogen and progesterone receptor status. Breast cancer risk was also associated with family history of colon cancer (IRR 1.35, 95% CI 1.12–1.63) and possibly with family history of leukemia (IRR 1.42, 95% CI 0.82–2.46).

Conclusions

These findings indicate a strong familial relationship for breast cancer in African American women. The associations with family history of colon cancer and leukemia warrant further investigation.

Keywords

Family history Breast cancer African American 

References

  1. 1.
    Edwards BK, Brown ML, Wingo PA et al (2005) Annual report to the nation on the status of cancer, 1975–2002, featuring population-based trends in cancer treatment. J Natl Cancer Inst 97:1407–1427PubMedCrossRefGoogle Scholar
  2. 2.
    Ghafoor A, Jemal A, Ward E, Cokkinides V, Smith R, Thun M (2003) Trends in breast cancer by race and ethnicity. CA Cancer J 53:342–355CrossRefGoogle Scholar
  3. 3.
    Joslyn SA, West MM (2000) Racial differences in breast carcinoma survival. Cancer 88:114–123CrossRefPubMedGoogle Scholar
  4. 4.
    Elledge RM, Clark GM, Chamness GC, Osborne CK (1994) Tumor biologic factors and breast cancer prognosis among white, Hispanic, and black women in the United States. J Natl Cancer Inst 86:705–712CrossRefPubMedGoogle Scholar
  5. 5.
    Henson DE, Chu KC, Levine PH (2003) Histologic grade, stage, and survival in breast carcinoma: comparison of African American and Caucasian women. Cancer 98:908–917CrossRefPubMedGoogle Scholar
  6. 6.
    Henson DE, Patierno SR (2004) Breast cancer aggressiveness and racial disparity. Breast Cancer Res Treat 87:291–296CrossRefPubMedGoogle Scholar
  7. 7.
    Newman LA, Mason J, Cote D, Vin Y, Carolin K, Bouwman D et al (2002) African-American ethnicity, socioeconomic status, and breast cancer survival: a meta-analysis of 14 studies involving over 10,000 African-American and 40,000 White American patients with carcinoma of the breast. Cancer 94:2844–2854CrossRefPubMedGoogle Scholar
  8. 8.
    Palmer JR, Wise LA, Horton NJ, Adams-Campbell LL, Rosenberg L (2003) Dual effect of parity on breast cancer risk in African-American women. J Natl Cancer Inst 95:478–483PubMedGoogle Scholar
  9. 9.
    Cox DR (1972) Regression model and life tables (with discussion). J R Stat Soc (B) 34:187–220Google Scholar
  10. 10.
    Schatzkin A, Palmer JR, Rosenberg L, Helmrich SP, Miller DR, Kaufman DW et al (1987) Risk factors for breast cancer in black women. J Natl Cancer Inst 78:213–217PubMedGoogle Scholar
  11. 11.
    Amos CI, Goldstein AM, Harris EL (1991) Familiality of breast cancer and socioeconomic status in blacks. Cancer Res 51:1793–1797PubMedGoogle Scholar
  12. 12.
    Simon MS, Korczak JF, Yee CL, Malone KE, Ursin G, Bernstein L et al (2006) Breast cancer risk estimates for relatives of white and African American women with breast cancer in the women’s contraceptive and reproductive experiences study. J Clin Oncol 24:2498–2504CrossRefPubMedGoogle Scholar
  13. 13.
    Kilfoy BA, Zhang Y, Shu XO, Gao YT, Ji BT, Yang G et al (2008) Family history of malignancies and risk of breast cancer: prospective data from the Shanghai women’s health study. Cancer Causes Control 19:1139–1145CrossRefPubMedGoogle Scholar
  14. 14.
    Collaborative Group on Hormonal Factors in Breast Cancer (2001) Familial breast cancer: collaborative reanalysis of individual data from 52 epidemiological studies including 58, 209 women with breast cancer and 101, 986 women without the disease. Lancet 358:1389–1399CrossRefGoogle Scholar
  15. 15.
    Welsh ML, Buist DS, Aiello Bowles EJ, Anderson ML, Elmore JG, Li CI (2009) Population-based estimates of the relation between breast cancer risk, tumor subtype, and family history. Breast Cancer Res Treat 114:549–558CrossRefPubMedGoogle Scholar
  16. 16.
    Tutera AM, Sellers TA, Potter JD, Drinkard CR, Wiesner GL, Folsom AR (1996) Association between family history of cancer and breast cancer defined by estrogen and progesterone receptor status. Genet Epidemiol 13:207–221CrossRefPubMedGoogle Scholar
  17. 17.
    Rawal R, Bertelsen L, Olsen JH (2006) Cancer incidence in first-degree relatives of a population-based set of cases of early-onset breast cancer. Eur J Cancer 42:3034–3040CrossRefPubMedGoogle Scholar
  18. 18.
    Hemminki K, Vaittinen P (1997) Effect of paternal and maternal cancer on cancer in the offspring: a population-based study. Cancer Epidemiol Biomarkers Prev 6:993–997PubMedGoogle Scholar
  19. 19.
    Slattery ML, Kerber RA (1993) A comprehensive evaluation of family history and breast cancer risk. The Utah population database. JAMA 270:1563–1568CrossRefPubMedGoogle Scholar
  20. 20.
    Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A, Feuer EJ, Thun MJ (2005) Cancer statistics, 2005. CA Cancer J Clin 55:10–30CrossRefPubMedGoogle Scholar
  21. 21.
    Ziogas A, Anton-Culver H (2003) Validation of family history data in cancer family registries. Am J Prev Med 24:190–198CrossRefPubMedGoogle Scholar
  22. 22.
    Malone KE, Daling JR, Doody DR, Hsu L, Bernstein L, Coates RJ et al (2006) Prevalence and predictors of BRCA1 and BRCA2 mutations in a population-based study of breast cancer in white and black American women ages 35 to 64 years. Cancer Res 66:8297–8308CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Julie R. Palmer
    • 1
  • Deborah A. Boggs
    • 1
  • Lucile L. Adams-Campbell
    • 2
  • Lynn Rosenberg
    • 1
  1. 1.Slone Epidemiology CenterBoston UniversityBostonUSA
  2. 2.Lombardi Comprehensive Cancer CenterGeorgetown UniversityWashingtonUSA

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