Cancer Causes & Control

, Volume 20, Issue 10, pp 1939–1945 | Cite as

Green tea consumption and the risk of liver cancer in Japan: the Ohsaki Cohort study

  • Akane Ui
  • Shinichi Kuriyama
  • Masako Kakizaki
  • Toshimasa Sone
  • Naoki Nakaya
  • Kaori Ohmori-Matsuda
  • Atsushi Hozawa
  • Yoshikazu Nishino
  • Ichiro Tsuji
Original paper



To investigate the association between green tea consumption and liver cancer incidence.


We prospectively followed 41,761 Japanese adults aged 40–79 years, without a history of cancer at the baseline or any missing data for green tea consumption frequency. Cox proportional hazards models were used to calculate hazard ratios (HR) with 95% confidence intervals (CI), adjusted for age, alcohol drinking, smoking, the consumption of coffee, vegetables, dairy products, fruit, fish, and soybean.


Over 9 years of follow-up, among 325,947 accrued person-years, the total incidence of liver cancer was 247 cases. We found that green tea consumption was inversely associated with the incidence of liver cancer. In men, the multivariate-adjusted HRs (95% CIs) for liver cancer incidence with different green tea consumption categories were 1.00 (reference) for <1 cup/day, 0.83 (0.53–1.30) for 1–2 cups/day, 1.11 (0.73–1.68) for 3–4 cups/day, and 0.63 (0.41–0.98) for ≥5 cups/day (p for trend = 0.11). The corresponding data among women were 1.00 (reference), 0.68 (0.35–1.31), 0.79 (0.44–1.44), 0.50 (0.27–0.90) (p for trend = 0.04).


Green tea consumption is associated with a reduced risk of liver cancer incidence.


Liver cancer Green tea Japanese Incidence 


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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Akane Ui
    • 1
  • Shinichi Kuriyama
    • 1
  • Masako Kakizaki
    • 1
  • Toshimasa Sone
    • 1
  • Naoki Nakaya
    • 1
  • Kaori Ohmori-Matsuda
    • 1
  • Atsushi Hozawa
    • 1
  • Yoshikazu Nishino
    • 2
  • Ichiro Tsuji
    • 1
  1. 1.Division of Epidemiology, Department of Public Health and Forensic MedicineTohoku University Graduate School of MedicineSendai, MiyagiJapan
  2. 2.Division of EpidemiologyMiyagi Cancer Center Research InstituteNatoriJapan

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