Cancer Causes & Control

, Volume 20, Issue 8, pp 1523–1528

Impact of a mixed strength and endurance exercise intervention on levels of adiponectin, high molecular weight adiponectin and leptin in breast cancer survivors

  • Jennifer A. Ligibel
  • Anita Giobbie-Hurder
  • Deanna Olenczuk
  • Nancy Campbell
  • Taylor Salinardi
  • Eric P. Winer
  • Christos S. Mantzoros
Brief report

Abstract

Evidence suggests that exercise affects breast cancer risk and outcomes, but little is known about the mechanisms through which this effect may be mediated. This study examines the impact of exercise upon levels of adiponectin, high molecular weight adiponectin (HMWA), and leptin in breast cancer survivors.

Methods

One hundred and one sedentary, overweight breast cancer survivors were randomized to a 16-week exercise intervention or usual care control group. Anthropometric measurements were taken and fasting levels of adiponectin, HMWA and leptin were collected at baseline and 16 weeks.

Results

Baseline and week-16 measurements were available for 81 patients. The exercise group experienced a significant decrease in hip measurements, with no change in weight or body composition. There were no significant changes in adiponectin, HMWA, or leptin in either group. Modeling analyses demonstrated a significant inverse relationship between changes in leptin and adiponectin, but no relationship between changes in BMI, waist or hip circumference, or body fat percentage and change in leptin or adiponectin.

Conclusions

This study did not demonstrate a significant change in adipocytokine levels in breast cancer survivors participating in an exercise intervention, suggesting that further work is needed to explore the mechanisms through which exercise may impact breast cancer.

Keywords

Breast cancer Physical activity Leptin Adiponectin High molecular weight adiponectin 

References

  1. 1.
    Gammon M, John E, Britton J (1998) Recreational and occupational physical activities and risk of breast cancer. J Natl Cancer Inst 90:100–117. doi:10.1093/jnci/90.2.100 PubMedCrossRefGoogle Scholar
  2. 2.
    McTiernan A, Kooperberg C, White E et al (2003) Recreational physical activity and the risk of breast cancer in postmenopausal women. J Am Med Assoc 290:1331–1336. doi:10.1001/jama.290.10.1331 CrossRefGoogle Scholar
  3. 3.
    Schaffler A, Scholmerich J, Buechler C (2007) Mechanisms of disease: adipokines and breast cancer-endocrine and paracrine mechanisms that connect adiposity and breast cancer. Nat Clin Pract Endocrinol Metab 3:345–354. doi:10.1038/ncpendmet0456 PubMedCrossRefGoogle Scholar
  4. 4.
    Crowther N, Ferris W, Ojwang P, Rheeder P (2006) The effect of abdominal obesity on insulin sensitivity and serum lipid and cytokine concentrations in African women. Clin Endocrinol 64:535–541CrossRefGoogle Scholar
  5. 5.
    Kraemer R, Chu H, Castracane V (2002) Leptin and exercise. Exp Biol Med 227:701–708Google Scholar
  6. 6.
    Kraemer R, Castracane V (2007) Exercise and humoral mediators of peripheral energy balance: ghrelin and adiponectin. Exp Biol Med 232:184–194Google Scholar
  7. 7.
    Pajvani U, Hawkins M, Combs T et al (2004) Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity. J Biol Chem 279:12152–12162. doi:10.1074/jbc.M311113200 PubMedCrossRefGoogle Scholar
  8. 8.
    Tabara Y, Osawa H, Kawamoto R et al (2008) Reduced high-molecular-weight adiponectin and elevated high-sensitivity C-Reactive Protein are synergistic risk factors for metabolic syndrome in a large-scale middle-aged to elderly population: the Shimanami Health Promoting Program Study. J Clin Endocrinol Metab 93:715–722. doi:10.1210/jc.2007-0397 PubMedCrossRefGoogle Scholar
  9. 9.
    Ligibel J, Campbell N, Partridge A et al (2008) Impact of a mixed strength and endurance exercise intervention on insulin levels in breast cancer survivors. J Clin Oncol 26:907–912. doi:10.1200/JCO.2007.12.7357 PubMedCrossRefGoogle Scholar
  10. 10.
    Holmes M, Chen W, Feskanich D, Kroenke C, Colditz G (2005) Physical activity and survival after breast cancer diagnosis. J Am Med Assoc 293:2479–2486. doi:10.1001/jama.293.20.2479 CrossRefGoogle Scholar
  11. 11.
    Holick C, Newcomb P, Trentham-Dietz A et al (2008) Physical activity and survival after diagnosis of invasive breast cancer. Cancer Epidemiol Biomarkers Prev 17:379–386. doi:10.1158/1055-9965.EPI-07-0771 PubMedCrossRefGoogle Scholar
  12. 12.
    Goodwin P, Ennis M, Pritchard K, Trudeau M (2002) Fasting insulin and outcome in early-stage breast cancer: results of a prospective cohort study. J Clin Oncol 20:42–51. doi:10.1200/JCO.20.1.42 PubMedCrossRefGoogle Scholar
  13. 13.
    Pollak M, Chapman J, Shepherd L (2006) Insulin resistance, estimated by serum C-peptide level, is associated with reduced event-free survival for postmenopausal women in NCIC CTG MA.14 adjuvant breast cancer trial. J Clin Oncol 24(18):524Google Scholar
  14. 14.
    Surmacz E (2007) Obesity hormone leptin: a new target in breast cancer? Breast Cancer Res 9:301–302PubMedGoogle Scholar
  15. 15.
    Rose D, Komninou D, Stephenson GD (2004) Obseity, adipocytokines, and insulin resistance in breast cancer. Obes Rev 5:153–165. doi:10.1111/j.1467-789X.2004.00142.x PubMedCrossRefGoogle Scholar
  16. 16.
    Körner A, Pazaitou-Panayiotou K, Kelesidis T et al (2007) Total and high molecular weight adiponectin in breast cancer: in vitro and in vivo studies. J Clin Endocrinol Metab 92:1041–1048. doi:10.1210/jc.2006-1858 PubMedCrossRefGoogle Scholar
  17. 17.
    Mantzoros C, Petridou E, Dessypris N et al (2004) Adiponectin and breast cancer risk. J Clin Endocrinol Metab 89:1102–1107. doi:10.1210/jc.2003-031804 PubMedCrossRefGoogle Scholar
  18. 18.
    Chen D, Chung Y, Yeh Y et al (2006) Serum adiponectin and leptin levels in Taiwanese breast cancer patients. Cancer Lett 237:109–114. doi:10.1016/j.canlet.2005.05.047 PubMedCrossRefGoogle Scholar
  19. 19.
    Tworoger S, Eliassen A, Kelesidis T et al (2007) Plasma adiponectin concentrations and risk of incident breast cancer. J Clin Endocrinol Metab 92:1510–1516. doi:10.1210/jc.2006-1975 PubMedCrossRefGoogle Scholar
  20. 20.
    Jen K, Djuric Z, DiLaura N et al (2004) Improvement of metabolism among obese breast cancer survivors in differing weight loss regimens. Obes Res 12:306–312. doi:10.1038/oby.2004.38 PubMedCrossRefGoogle Scholar
  21. 21.
    Fatouros I, Tournis S, Leontsini D et al (2005) Leptin and adiponectin responses in overweight inactive elderly following resistance training and detraining are intensity related. J Clin Endocrinol Metab 90:5970–5977. doi:10.1210/jc.2005-0261 PubMedCrossRefGoogle Scholar
  22. 22.
    Kondo T, Kobayashi I, Murakami M (2006) Effect of exercise on circulating adipokine levels in obese young women. Endocr J 53:189–195. doi:10.1507/endocrj.53.189 PubMedCrossRefGoogle Scholar
  23. 23.
    Reseland J, Anderssen S, Solvoll K et al (2001) Effect of long-term changes in diet and exercise on plasma leptin concentrations. Am J Clin Nutr 73:240–245PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Jennifer A. Ligibel
    • 1
  • Anita Giobbie-Hurder
    • 1
  • Deanna Olenczuk
    • 2
  • Nancy Campbell
    • 1
  • Taylor Salinardi
    • 1
  • Eric P. Winer
    • 1
  • Christos S. Mantzoros
    • 2
  1. 1.Department of Medical Oncology, Dana-Farber Cancer InstituteHarvard Medical SchoolBostonUSA
  2. 2.Beth Israel HospitalHarvard Medical SchoolBostonUSA

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