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Cancer Causes & Control

, 20:1117 | Cite as

Phytoestrogen consumption and endometrial cancer risk: a population-based case–control study in New Jersey

  • Elisa V. Bandera
  • Melony G. Williams
  • Camelia Sima
  • Sharon Bayuga
  • Katherine Pulick
  • Homer Wilcox
  • Robert Soslow
  • Ann G. Zauber
  • Sara H. Olson
Original Paper

Abstract

Phytoestrogens have been shown to exert anti-estrogenic and estrogenic effects in some tissues, including the breast. However, only a few studies have evaluated their role in endometrial cancer risk. We evaluated this association in a population-based case–control study in New Jersey. A total of 424 cases and 398 controls completed an interview, including a food frequency questionnaire with supplemental questions for phytoestrogen foods. Risk estimates were derived using an unconditional logistic regression, adjusting for major risk factors for endometrial cancer. There was some suggestion of a decreased risk with quercetin intake (OR: 0.65; 95% CI: 0.41–1.01 for the highest compared to the lowest quartile; p for trend: 0.02). We found a limited evidence of an association with any of the lignans evaluated, total lignans, coumestrol, individual isoflavones, total isoflavones, or total phytoestrogens. However, there was some suggestion of an inverse association with total isoflavone intake limited to lean women (BMI <25; OR for the highest tertile: 0.50; 95% CI: 0.25–0.98) and those with a waist-to-hip ratio ≤0.85 (OR: 0.59; 95% CI: 0.33–1.05). There was no evidence of effect modification by HRT use. This study suggests a reduction in endometrial cancer risk with quercetin intake and with isoflavone intake in lean women.

Keywords

Endometrial neoplasms Phytoestrogens Isoflavones Lignans Quercetin Diet 

Abbreviations

OR

Odds ratio

CI

Confidence interval

FFQ

Food frequency questionnaire

BMI

Body mass index

WHR

Waist-to-hip ratio

HRT

Hormone replacement therapy

ERT

Estrogen replacement therapy

OC

Oral contraceptives

Notes

Acknowledgments

We thank the interviewers and students who were involved in this study (Silvia Brendel, Dina Gifkins, Nora Geraghty, June Kittredge, Elinor Miller, Louise Salant, Mathilde Saxon, Elizabeth Ward, Doreen Wass, Kay Yoon), the New Jersey Department of Health and Senior Services personnel (Tara Blando, Joan Kay, Betsy Kohler, Kevin Masterson, and Helen Weiss), as well as all the participants who generously donated their time to the study. This work was funded by NIH-K07 CA095666 and R01CA83918.

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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Elisa V. Bandera
    • 1
    • 2
  • Melony G. Williams
    • 1
    • 2
  • Camelia Sima
    • 3
  • Sharon Bayuga
    • 3
  • Katherine Pulick
    • 3
  • Homer Wilcox
    • 5
  • Robert Soslow
    • 4
  • Ann G. Zauber
    • 3
  • Sara H. Olson
    • 3
  1. 1.The Cancer Institute of New JerseyRobert Wood Johnson Medical SchoolNew BrunswickUSA
  2. 2.School of Public HealthUniversity of Medicine and Dentistry of New JerseyPiscatawayUSA
  3. 3.Department of Epidemiology and BiostatisticsMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  4. 4.Department of PathologyMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  5. 5.New Jersey Department of Health and Senior ServicesTrentonUSA

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