Cancer Causes & Control

, Volume 20, Issue 4, pp 491–496 | Cite as

Maximizing resources to study an uncommon cancer: E2C2—Epidemiology of Endometrial Cancer Consortium

  • Sara H. Olson
  • Chu Chen
  • Immaculata De Vivo
  • Jennifer A. Doherty
  • Virginia Hartmuller
  • Pamela L. Horn-Ross
  • James V. LaceyJr.
  • Shannon M. Lynch
  • Leah Sansbury
  • V. Wendy Setiawan
  • Leo J. Schouten
  • Xiao Ou Shu
Brief Report


Endometrial cancer affects more than 40,000 women a year in the U.S. While the association of this disease with high body mass index and sex steroid hormones is well known, there are many questions about etiology that have not been resolved. Little is known about the genetic basis for risk associated with hormones or obesity, other common genetic factors associated with risk, or gene–environment interactions. E2C2, the Epidemiology of Endometrial Cancer Consortium, was formed in 2006 to provide a collaborative environment for addressing these questions by pooling data from existing studies. This allows for investigations of uncommon risk factors, risk for rare histologic subtypes, and associations within strata that cannot be achieved in individual studies. This report describes the establishment of the consortium, ongoing projects that demonstrate the advantages of collaborative efforts, and challenges faced. Overall, the consortium promises to provide an important means of furthering our knowledge about this cancer.


Endometrial cancer Epidemiology 



We thank the Robert Howard Family Foundation for its gift to MSKCC that enabled the establishment of the E2C2 database. We thank Dana Christo, Heather Feigelson, Marc Goodman, Timothy Rebbeck, Daniela Seminara, Elisabete Weiderpass, and Anne Zeleniuch-Jacquotte for their participation in the development of E2C2.

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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Sara H. Olson
    • 1
  • Chu Chen
    • 2
    • 3
    • 4
  • Immaculata De Vivo
    • 5
    • 6
  • Jennifer A. Doherty
    • 2
  • Virginia Hartmuller
    • 7
  • Pamela L. Horn-Ross
    • 8
  • James V. LaceyJr.
    • 9
  • Shannon M. Lynch
    • 7
  • Leah Sansbury
    • 7
  • V. Wendy Setiawan
    • 10
  • Leo J. Schouten
    • 11
  • Xiao Ou Shu
    • 12
    • 13
    • 14
  1. 1.Department of Epidemiology and BiostatisticsMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  2. 2.Program in Epidemiology, Division of Public Health SciencesFred Hutchinson Cancer Research CenterSeattleUSA
  3. 3.Department of Epidemiology, School of Public Health and Community MedicineUniversity of WashingtonSeattleUSA
  4. 4.Department of Otolaryngology: Head and Neck Surgery, School of MedicineUniversity of WashingtonSeattleUSA
  5. 5.Channing Laboratory, Department of MedicineBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA
  6. 6.Department of EpidemiologyHarvard School of Public HealthBostonUSA
  7. 7.Epidemiology & Genetics Research Program, Division of Cancer Control and Population SciencesNational Cancer InstituteBethesdaUSA
  8. 8.Northern California Cancer CenterFremontUSA
  9. 9.Hormonal and Reproductive Epidemiology Branch, Division of Cancer Epidemiology and GeneticsNational Cancer InstituteRockvilleUSA
  10. 10.Department of Preventive Medicine, Keck School of MedicineUniversity of Southern CaliforniaLos AngelesUSA
  11. 11.Department of Epidemiology, GROW – School for Oncology and Developmental BiologyMaastricht UniversityMaastrichtThe Netherlands
  12. 12.Vanderbilt Epidemiology CenterVanderbilt Institute of Medicine and Public HealthNashvilleUSA
  13. 13.Department of MedicineVanderbilt University Medical CenterNashvilleUSA
  14. 14.Vanderbilt-Ingram Cancer CenterNashvilleUSA

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