Maximizing resources to study an uncommon cancer: E2C2—Epidemiology of Endometrial Cancer Consortium
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Endometrial cancer affects more than 40,000 women a year in the U.S. While the association of this disease with high body mass index and sex steroid hormones is well known, there are many questions about etiology that have not been resolved. Little is known about the genetic basis for risk associated with hormones or obesity, other common genetic factors associated with risk, or gene–environment interactions. E2C2, the Epidemiology of Endometrial Cancer Consortium, was formed in 2006 to provide a collaborative environment for addressing these questions by pooling data from existing studies. This allows for investigations of uncommon risk factors, risk for rare histologic subtypes, and associations within strata that cannot be achieved in individual studies. This report describes the establishment of the consortium, ongoing projects that demonstrate the advantages of collaborative efforts, and challenges faced. Overall, the consortium promises to provide an important means of furthering our knowledge about this cancer.
KeywordsEndometrial cancer Epidemiology
We thank the Robert Howard Family Foundation for its gift to MSKCC that enabled the establishment of the E2C2 database. We thank Dana Christo, Heather Feigelson, Marc Goodman, Timothy Rebbeck, Daniela Seminara, Elisabete Weiderpass, and Anne Zeleniuch-Jacquotte for their participation in the development of E2C2.
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