Metabolic factors and subsequent risk of hepatocellular carcinoma by hepatitis virus infection status: a large-scale population-based cohort study of Japanese men and women (JPHC Study Cohort II)
- First Online:
- 268 Downloads
The association between metabolic factors and hepatocellular carcinoma (HCC) has not been well clarified. We prospectively examined whether metabolic factors predicts the subsequent risk of HCC in the Japan Public Health Center-based Prospective Study Cohort II, in consideration of hepatitis virus infection status.
A total of 17,590 subjects aged 40–69 participating in a questionnaire and health checkup survey during 1993–1994 were followed for incidence of HCC through 2006. A total of 102 cases of HCC were newly documented. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated for metabolic factors controlling for potential confounding factors.
The presence of metabolic factors in the aggregate was associated with a significantly increased risk of HCC, especially with hepatitis virus infection. HCC was positively associated particularly with high glucose (HR = 1.75, CI = 1.11–2.74) and overweight (HR = 2.22, CI = 1.42–3.48). Results were similar when analyses were limited to subjects with HCV infection.
Although metabolic factors in the aggregate may be associated with an increased risk of HCC, the main contributors to this association under HCV infection appear to be overweight and high glucose. Improvement of these factors may be a crucial target in preventing progression to HCC in those with HCV infection.
KeywordsMetabolic factor Hepatocellular carcinoma Cohort study Overweight High glucose
- 5.El-Serag HB, Hampel H, Javadi F (2007) The Editorial Board of the Cancer Statistics in Japan. Cancer statistics in Japan 2007. Foundation for Promotion of Cancer Research (FPFR), TokyoGoogle Scholar
- 10.Chen CL, Yang HI, Yang WS, Liu CJ, Chen PJ, You SL, Wang LY, Sun CA, Lu SN, Chen DS, Chen CJ (2008) Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: a follow-up study in Taiwan. Gastroenterology 135:111–121. doi:10.1053/j.gastro.2008.03.073 PubMedCrossRefGoogle Scholar
- 30.Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, Spertus JA, Costa F (2005) Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 112:2735–2752. doi:10.1161/CIRCULATIONAHA.105.169404 PubMedCrossRefGoogle Scholar
- 34.Abdel-Hamid M, El-Daly M, El-Kafrawy S, Mikhail N, Strickland GT, Fix AD (1990) World Health Organization International classification of diseases and health related problem, 10th revision. World Health Organization, Geneva, SwitzerlandGoogle Scholar
- 35.Abdel-Hamid M, El-Daly M, El-Kafrawy S, Mikhail N, Strickland GT, Fix AD (2000) World Health Organization International classification of diseases for oncology, 3rd edn. World Health Organization, Geneva, SwitzerlandGoogle Scholar
- 36.Abdel-Hamid M, El-Daly M, El-Kafrawy S, Mikhail N, Strickland GT, Fix AD (2007) Stata Corporation Stata Statistical Software. Stata Corporation, College Station, TXGoogle Scholar
- 39.Jan CF, Chen CJ, Chiu YH, Chen LS, Wu HM, Huang CC, Yen MF, Chen TH (2006) A population-based study investigating the association between metabolic syndrome and hepatitis B/C infection (Keelung Community-based Integrated Screening study No. 10). Int J Obes (Lond) 30:794–799. doi:10.1038/sj.ijo.0803204 CrossRefGoogle Scholar
- 40.Siagris D, Christofidou M, Theocharis GJ, Pagoni N, Papadimitriou C, Lekkou A, Thomopoulos K, Starakis I, Tsamandas AC, Labropoulou-Karatza C (2006) Serum lipid pattern in chronic hepatitis C: histological and virological correlations. J Viral Hepat 13:56–61. doi:10.1111/j.1365-2893.2005.00655.x PubMedCrossRefGoogle Scholar