A population-based, case–control study of green tea consumption and leukemia risk in southwestern Taiwan
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This study investigated the association between green tea consumption and leukemia.
A total of 252 cases (90.3% response) and 637 controls (53.4% response) were enrolled. Controls were matched for cases on age and gender. Information was collected on participants’ living habits, including tea consumption. Green tea was used as a standard to estimate the total amount of individual catechin consumption. We stratified individual consumption of catechins into four levels. Conditional logistic regression models were fit to subjects aged 0–15 and 16–29 years to evaluate separate associations between leukemia and catechin consumption.
A significant inverse association between green tea consumption and leukemia risk was found in individuals aged 16–29 years, whereas no significant association was found in the younger age groups. For the older group with higher amounts of tea consumption (>550 units of catechins), the adjusted odds ratio (OR) compared with the group without tea consumption was 0.47 [95% confidence interval (CI) = 0.23–0.97]. After we adjusted for smoking status and medical irradiation exposure, the overall OR for all participants was 0.49 (95% CI = 0.27–0.91), indicating an inverse relation between large amounts of catechins and leukemia.
Drinking sufficient amounts of tea, especially green tea, which contains more catechins than oolong tea and black tea, may reduce the risk of leukemia.
KeywordsAsia Catechin Childhood Leukemia Epidemiology Green Tea
The authors gratefully acknowledge Chien-Chin Chou for questionnaire data verification, Janna Frelich for data management, and Thomas J., Yuhao Chen, and Lia Shimada for technical assistance. The study was funded by National Institutes of Health (ES09723, ES00002). The members of the Kaohsiung Leukemia Research Group were as follows: Kaohsiung Medical University Chung-Ho Memorial Hospital—Tai-Tsung Chang, Sheng-Fung Lin, Shyh-Shin Chiou, Ren-Chin Jang, Hui-Hua Hsiao, Ta-Chih Liu, and Pei-Chin Lin; Kaohsiung Chang Gung Memorial Hospital—Chih-Cheng Hsiao, Jiunn-Ming Sheen, Ching-Yuan Kuo, Ming-Chung Wang, Cheng-Hua Huang, and Chung-Bin Huang; and Kaohsiung Veterans General Hospital—Shyh-Jer Lin, Yu-Ming Sun, Kai-Sheng Hsieh, and Yu-Hsiang Chang; and Shaw Chwan Memorial Hospital—Yuk-Cheung Wong; and E-Da Hospital—Hung-Bo Wu.
National Institutes of Health (ES09723, ES00002).
Conflict of interest
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