Cancer Causes & Control

, Volume 19, Issue 10, pp 1201–1207

A case–control study of childhood brain tumors and fathers’ hobbies: a Children’s Oncology Group study

  • Andrea L. Rosso
  • Mary E. Hovinga
  • Lucy B. Rorke-Adams
  • Logan G. Spector
  • Greta R. Bunin
Original Paper

DOI: 10.1007/s10552-008-9189-7

Cite this article as:
Rosso, A.L., Hovinga, M.E., Rorke-Adams, L.B. et al. Cancer Causes Control (2008) 19: 1201. doi:10.1007/s10552-008-9189-7

Abstract

Objective

A comprehensive case–control study was conducted to evaluate parental risk factors for medulloblastoma (MB) and primitive neuroectodermal tumor (PNET). This analysis was conducted to evaluate associations between fathers’ hobbies and risk of their children developing MB/PNET. The hobbies chosen for study were those with similar exposures as occupations associated with childhood cancers.

Methods

Cases were 318 subjects under six years of age at diagnosis between 1991 and 1997 and registered with the Children’s Cancer Group. An equal number of controls were selected through random digit dialing and individually matched to cases.

Results

In multivariate analyses, a significant association was seen for lawn care with pesticides [during pregnancy: odds ratio (OR) = 1.6, 95% confidence interval (CI): 1.0, 2.5; after birth: OR = 1.8, 95% CI: 1.2, 2.8] and a weak association was seen for stripping paint [during pregnancy: OR = 1.4, 95% CI: 0.8, 2.6; after birth: OR = 1.4, 95% CI: 0.7, 2.6].

Conclusions

This study suggests that household exposures from hobbies, particularly pesticides, may increase risk of MB/PNET in children; previous research has been mostly limited to occupational exposures.

Keywords

Case–control studies Brain neoplasms Medulloblastomas Child preschool Infant Hobbies Pesticides 

Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Andrea L. Rosso
    • 1
    • 2
  • Mary E. Hovinga
    • 1
  • Lucy B. Rorke-Adams
    • 3
    • 4
  • Logan G. Spector
    • 5
    • 6
  • Greta R. Bunin
    • 7
  1. 1.Department of Epidemiology and BiostatisticsDrexel University School of Public HealthPhiladelphiaUSA
  2. 2.Department of NeurologyDrexel University College of MedicinePhiladelphiaUSA
  3. 3.Department of Pediatrics, Department of Pathology and Department of NeurologyUniversity of Pennsylvania School of MedicinePhiladelphiaUSA
  4. 4.Department of Pathology, Department of Neurology and Department of PediatricsChildren’s Hospital of PhiladelphiaPhiladelphiaUSA
  5. 5.Division of Epidemiology and Clinical Research, Department of PediatricsUniversity of MinnesotaMinneapolisUSA
  6. 6.University of Minnesota Cancer CenterMinneapolisUSA
  7. 7.Division of Oncology, Department of PediatricsChildren’s Hospital of PhiladelphiaPhiladelphiaUSA

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