Cancer Causes & Control

, Volume 19, Issue 9, pp 975–980

Association of the TCF7L2 polymorphism with colorectal cancer and adenoma risk

  • Aditi Hazra
  • Charles S. Fuchs
  • Andrew T. Chan
  • Edward L. Giovannucci
  • David J. Hunter
Original Paper


We evaluated the association of a polymorphism in TCF7L2 (RS12255372) in the WNT signaling pathway, which previously has been strongly associated with risk of Type II Diabetes, with colorectal cancer (CRC) and adenoma in the prospective Nurses’ Health Study (NHS) and Health Professionals Follow-up Study (HPFS) cohorts. Hyperinsulinemia may be related to the risk of colon adenoma and cancer, therefore this variant associated with reduced insulin secretion would be predicted to be inversely associated with colorectal cancer. Overall, in the NHS and HPFS, there was suggestive evidence for an inverse association associated with homozygosity for the minor allele of RS12255372 (TCF7L2 TT) and CRC (conditional and covariate adjusted OR = 0.63, 95% CI: 0.37–1.08; P for heterogeneity 0.52 for the association in women and men). In summary, the marginal association of the TCF7L2 SNP with CRC might be due to chance, but warrants further laboratory and epidemiological investigation.


TCF7L2 Polymorphism WNT pathway Colorectal cancer Colorectal adenoma 



Confidence interval


Colorectal cancer


Health Professionals Follow-up Study


Nurses’ Health Study


Odds Ratio


Single nucleotide polymorphisms


T-cell factor 7 like 2


Type II Diabetes


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Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Aditi Hazra
    • 1
    • 2
  • Charles S. Fuchs
    • 2
    • 3
  • Andrew T. Chan
    • 2
  • Edward L. Giovannucci
    • 2
    • 4
  • David J. Hunter
    • 1
    • 2
    • 4
  1. 1.Program in Molecular and Genetic Epidemiology, Department of EpidemiologyHarvard School of Public HealthBostonUSA
  2. 2.Channing Laboratory, Department of MedicineBrigham and Women’s Hospital and Harvard Medical SchoolBostonUSA
  3. 3.Department of Medical OncologyDana-Farber Cancer InstituteBostonUSA
  4. 4.Department of NutritionHarvard School of Public HealthBostonUSA

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