Cancer Causes & Control

, Volume 19, Issue 7, pp 759–765

Malignant melanoma risk after exposure to fertility drugs: results from a large Danish cohort study

  • Charlotte Gerd Hannibal
  • Allan Jensen
  • Heidi Sharif
  • Susanne Krüger Kjaer
Original Paper

DOI: 10.1007/s10552-008-9138-5

Cite this article as:
Hannibal, C.G., Jensen, A., Sharif, H. et al. Cancer Causes Control (2008) 19: 759. doi:10.1007/s10552-008-9138-5

Abstract

Objective

The aim was to examine the effects of fertility drugs on malignant melanoma risk using data from the largest cohort of infertile women to date.

Methods

A cohort of 54,362 women with infertility problems referred to Danish fertility clinics in the period 1963–1998 was established. A detailed data collection including information about type and amount of treatment was conducted. Using case–cohort techniques, we calculated rate ratios (RRs) of malignant melanoma associated with different fertility drugs after adjustment for parity status.

Results

112 malignant melanomas were identified during follow-up through 2000. Use of clomiphene, gonadotrophins, hCG or GnRH did not affect risk of malignant melanoma significantly. When stratifying for parity, however, use of gonadotrophins (RR = 2.29; CI: 1.16–4.52) or GnRH (RR = 3.26; 95% CI: 1.50–7.09) among parous women was associated with a significant increased risk. For all groups of fertility drugs, we found no association with number of cycles of use or years since first use (latency).

Conclusions

Our findings showed no strong association between malignant melanoma risk and use of fertility drugs, although the results indicated that use of gonadotrophins or GnRH might increase risk in parous women. Longer follow-up is needed to confirm our findings.

Keywords

Malignant melanoma Infertility Fertility drugs Clomiphene Gonadotrophins 

Copyright information

© Springer Science+Business Media B.V. 2008

Authors and Affiliations

  • Charlotte Gerd Hannibal
    • 1
  • Allan Jensen
    • 1
  • Heidi Sharif
    • 1
  • Susanne Krüger Kjaer
    • 1
    • 2
  1. 1.Department of Viruses, Hormones and CancerInstitute of Cancer Epidemiology, Danish Cancer SocietyCopenhagenDenmark
  2. 2.The Juliane Marie CentreCopenhagen University HospitalCopenhagenDenmark

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