Faupel-Badger, J.M., Kidd, L.C.R., Albanes, D. et al. Cancer Causes Control (2008) 19: 119. doi:10.1007/s10552-007-9077-6
Animal and in vitro models of prostate cancer demonstrate high IL-10 levels result in smaller tumors, fewer metastases, and reduced angiogenesis compared to controls. We sought to examine the hypothesis that genotypes correlated with low IL-10 production may be associated with increased prostate cancer risk among Finnish male participants from the Alpha-tocopherol Beta-carotene Cancer Prevention Study. DNA from 584 prostate cancer cases and 584 controls was genotyped for four IL-10 alleles, −1082, −819, −592, and 210. DNA from more of the controls than cases failed to amplify, resulting in 509 cases and 382 controls with genotype data for −1082; 507 and 384 for −819; 511 and 386 for −592; and 491 and 362 for 210. Odds ratios for the association between the IL-10 genotypes and risk of prostate cancer or, among cases only, high-grade disease were calculated using logistic regression. In this population, the −819 TT and −592 AA low expression genotypes were highly correlated. These two genotypes also were associated with increased prostate cancer susceptibility (OR = 1.92, 95% CI 1.07–3.43 for −819) and, among cases, with high-grade tumors (OR = 2.56, 95% CI 1.26–5.20 for −819). These data demonstrate genotypes correlated with low IL-10 production are associated with increased risk of prostate cancer and with high-grade disease in this population.
1.Cancer Prevention Fellowship Program, Division of Cancer Prevention and Mammary Biology and Tumorigenesis Laboratory, Center for Cancer ResearchNational Cancer Institute, National Institutes of HealthBethesdaUSA
2.Cancer Prevention & Control Program, Department of Pharmacology & Toxicology, James Graham Brown Cancer CenterUniversity of Louisville School of MedicineLouisvilleUSA
3.Nutritional Epidemiology Branch, Division of Cancer Epidemiology and GeneticsNational Cancer Institute, National Institutes of HealthBethesdaUSA
4.Department of Health Promotion and Chronic Disease PreventionNational Public Health InstituteHelsinkiFinland
5.Cancer Genetics Branch, Center for Cancer ResearchNational Cancer Institute, National Institutes of HealthBethesdaUSA
6.Prostate and Urologic Cancer Research Group, Division of Cancer PreventionNational Cancer Institute, National Institutes of HealthBethesdaUSA