Body mass index, physical activity and the risk of pancreatic cancer in relation to smoking status and history of diabetes: a large-scale population-based cohort study in Japan–The JPHC study
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The effects of BMI and physical activity on the risk of pancreatic cancer were investigated in a large population-based cohort study in Japan (JPHC study). In particular, we explored how these effects were influenced by smoking status and a history of diabetes.
In total, 99,670 participants (47,499 men, and 52,171women) were followed for an average of 11 years through the end of 2003. Hazard ratios (HR) and their 95% confidence intervals (CI) were estimated by Cox proportional hazards models.
A total of 224 incident cases (128 men, 96 women) of pancreatic cancer were identified. A statistically significant excess risk of pancreatic cancer was associated with current smoking (HR = 1.8, CI 1.1–3.0) and a history of diabetes (HR = 2.1, CI 1.3–3.5) among men. A similar increase in risk associated with current smoking (HR = 2.0, CI 0.9–4.4) and diabetes (HR = 1.5, CI 0.7–3.5) was also seen among women. BMI was inversely associated with risk of pancreatic cancer among men, especially among current male smokers or diabetes patients, but no association was found among women. Leisure-time physical activity was not associated with risk in either men or women.
Our study confirms the association between cigarette smoking, history of diabetes and increased risk of pancreatic cancer. However, our data suggest that the association between BMI and risk of pancreatic cancer in this Japanese population may be different from that in Western populations.
KeywordsBMI Physical activity Pancreatic cancer Risk factors Smoking diabetes
This study was supported by a Grant-in-Aid from the Cancer Research and Third-Term Comprehensive Control Research for Cancer from the Ministry of Labor, Health and Welfare of Japan. J.L. was partly supported by the SVENSKA SÄLLSKAPET FÖR MEDICINSK FORSKNING (SSMF) and the Karolinska Institutet Travel Fund.
- 5.Everhart J, Wright D (1995) Diabetes mellitus as a risk factor for pancreatic cancer. A meta-anal JAMA 273:1605–1609Google Scholar
- 13.IARC (2002) IARC handbooks of cancer prevention, vol 6. IARC press, LyonGoogle Scholar
- 15.Patel AV, Rodriguez C, Bernstein L, Chao A, Thun MJ, Calle EE (2005) Obesity, recreational physical activity, and risk of pancreatic cancer in a large U.S. Cohort. Cancer Epidemiol Biomarkers Prev 14:459–466Google Scholar
- 17.Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ (2003) Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 348:1625–1638Google Scholar
- 25.Mannami T, Konishi M, Baba S, Nishi N, Terao A (1997) Prevalence of asymptomatic carotid atherosclerotic lesions detected by high-resolution ultrasonography and its relation to cardiovascular risk factors in the general population of a Japanese city: the Suita study. Stroke 28:518–525PubMedGoogle Scholar
- 38.Silverman DT, Swanson CA, Gridley G, Wacholder S, Greenberg RS, Brown LM, Hayes RB, Swanson GM, Schoenberg JB, Pottern LM, Schwartz AG, Fraumeni JF Jr, Hoover RN (1998) Dietary and nutritional factors and pancreatic cancer: a case–control study based on direct interviews. J Natl Cancer Inst 90:1710–1719PubMedCrossRefGoogle Scholar
- 53.The Asia-Pacific perspective (2000) Redefining obesity and its treatment, S. Committee (ed) International Diabetes Institute, MelbourneGoogle Scholar