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Cancer Causes & Control

, Volume 18, Issue 4, pp 449–455 | Cite as

Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract

  • Daniele Campa
  • Mia Hashibe
  • David Zaridze
  • Neonila Szeszenia-Dabrowska
  • Ioan Nicolae Mates
  • Vladimir Janout
  • Ivana Holcatova
  • Eleonóra Fabiánová
  • Valérie Gaborieau
  • Rayjean J. Hung
  • Paolo Boffetta
  • Paul Brennan
  • Federico CanzianEmail author
Brief Report

Abstract

Objectives

The purpose of this study was to investigate the role of polymorphisms of genes involved in inflammation in the risk of cancers of the upper aerodigestive tract (UADT).

Methods

We have evaluated the role of polymorphisms in key genes related to inflammation, namely IL1B (rs1143627), COX2/PTGS2 (rs5275), and IL8 (rs4073) in a large case–control study comprising 811 UADT cancer cases and 1,083 controls.

Results

An association was observed for squamous cell carcinoma of the pharynx for a polymorphism in the promoter of the IL1B gene, with an OR of 2.39 (95% CI = 1.19–4.81) for the homozygotes for the minor allele A promoter polymorphism of IL8 was associated with decreased risk of laryngeal cancer, with an OR of 0.70 (95% CI = 0.50–0.98) for carriers of the minor allele.

Conclusions

To our knowledge, this is the first report on the role of these polymorphisms with respect to UADT carcinogenesis. Our results suggest that inflammation-related polymorphisms play a role, albeit minor, in the risk of developing cancers of the upper aerodigestive tract.

Keywords

Interleukin-1 Interleukin-8 Cyclooxygenase-2 Upper aerodigestive tract cancers Oral cancer Pharynx cancer Larynx cancer Esophageal cancer 

Notes

Acknowledgments

This work was supported by grants from the European Commission’s INCO-COPERNICUS Program (Contract No. IC15-CT98-0332), the US National Institutes of Health/National Cancer Institute (CA92039) and the World Cancer Research Foundation (WCRF 99A28). Daniele Campa was a recipient of a fellowship by the University of Pisa and a special training award by the International Agency for Research on Cancer.

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Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Daniele Campa
    • 1
    • 2
  • Mia Hashibe
    • 1
  • David Zaridze
    • 3
  • Neonila Szeszenia-Dabrowska
    • 4
  • Ioan Nicolae Mates
    • 5
  • Vladimir Janout
    • 6
  • Ivana Holcatova
    • 7
  • Eleonóra Fabiánová
    • 8
  • Valérie Gaborieau
    • 1
  • Rayjean J. Hung
    • 1
  • Paolo Boffetta
    • 1
  • Paul Brennan
    • 1
  • Federico Canzian
    • 1
    • 9
    Email author
  1. 1.International Agency for Research on CancerLyonFrance
  2. 2.Department of BiologyUniversita’ di PisaPisaItaly
  3. 3.Institute of CarcinogenesisCancer Research CenterMoscowRussia
  4. 4.Department of Occupational and Environmental EpidemiologyInstitute of Occupational MedicineLodzPoland
  5. 5.University of Medicine and Pharmacy “Carol Davila”BucharestRomania
  6. 6.Department of Preventive Medicine, Faculty of MedicinePalacky UniversityOlomoucCzech Republic
  7. 7.Institute of Hygiene and Epidemiology, First Faculty of MedicineCharles UniversityPragueCzech Republic
  8. 8.Department of Occupational HealthSpecialized State Health InstituteBanska BystricaSlovakia
  9. 9.German Cancer Research Center (DKFZ)HeidelbergGermany

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