Cancer Causes & Control

, Volume 18, Issue 5, pp 571–579

Point and interval estimates of partial population attributable risks in cohort studies: examples and software

Original Paper

DOI: 10.1007/s10552-006-0090-y

Cite this article as:
Spiegelman, D., Hertzmark, E. & Wand, H.C. Cancer Causes Control (2007) 18: 571. doi:10.1007/s10552-006-0090-y


The concept of the population attributable risk (PAR) percent has found widespread application in public health research. This quantity describes the proportion of a disease which could be prevented if a specific exposure were to be eliminated from a target population. We present methods for obtaining point and interval estimates of partial PARs, where the impact on disease burden for some presumably modifiable determinants is estimated in, and applied to, a cohort study. When the disease is multifactorial, the partial PAR must, in general, be used to quantify the proportion of disease which can be prevented if a specific exposure or group of exposures is eliminated from a target population, while the distribution of other modifiable and non-modifiable risk factors is unchanged. The methods are illustrated in a study of risk factors for bladder cancer incidence (Michaud DS et al., New England J Med 340 (1999) 1390). A user-friendly SAS macro implementing the methods described in this paper is available via the worldwide web.


Population attributable risk Relative risk Epidemiologic methods Cohort studies Statistics Burden of disease 

Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  1. 1.Departments of Epidemiology, School of Public HealthHarvard UniversityBostonUSA
  2. 2.Departments of Biostatistics, School of Public HealthHarvard UniversityBostonUSA
  3. 3.National Center in HIV Epidemiology and Clinical ResearchUniversity of New South WalesDarlinghurstAustralia

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