Cancer Causes & Control

, 18:229 | Cite as

Lung cancer mortality and body mass index in a Japanese cohort: findings from the Japan Collaborative Cohort Study (JACC Study)

  • Takaaki Kondo
  • Yoko Hori
  • Hiroshi Yatsuya
  • Koji Tamakoshi
  • Hideaki Toyoshima
  • Yoshikazu Nishino
  • Nao Seki
  • Yoshinori Ito
  • Koji Suzuki
  • Kotaro Ozasa
  • Yoshiyuki Watanabe
  • Masahiko Ando
  • Kenji Wakai
  • Akiko Tamakoshi
Brief Report

Abstract

Objective:

To determine the relationship of body mass index (BMI) and BMI changes during adulthood to lung cancer mortality in a large-sized Japanese cohort.

Methods:

We followed 29,350 men for a maximum of 11 years in the Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study), which was initiated from 1988 to 1990. Complementary log–log modeling was employed with age, smoking status, and family history of lung cancer as covariates. Anthropometric measurements used were BMI at baseline, BMI around age 20, and adulthood BMI loss defined between the two measurements. Independent effects of these three measurements on lung cancer mortality were evaluated by applying the method of generalized estimation equations to the model for adjustment of intra-individual correlation.

Results:

Never smokers showed that high BMI both at baseline and around age 20 significantly predict lung cancer mortality (P < 0.05). Adulthood BMI loss significantly (P < 0.05) elevated the risk for lung cancer mortality among current smokers, implying their enhanced vulnerability to lung cancer risk among smokers.

Conclusions:

The risk for lung cancer mortality is elevated by a mechanism related to smoking-induced weight loss during adulthood.

Keywords

Body mass index Cohort study Complementary log–log model Generalized estimating equation 

Abbreviations

BMI

Body mass index

ICD

International classification of diseases

GEE

Generalized estimating equations

RR

Relative risk

CI

Confidence interval

CVD

Cardiovascular disease

Notes

Acknowledgments

The authors wish to express their appreciation to Dr. Kunio Aoki, Professor Emeritus, Nagoya University School of Medicine and former chairman of the JACC Study Group, and to Dr. Haruo Sugano, former Director of the Cancer Institute of Japanese Foundation for Cancer Research, both of whom greatly contributed to the initiation of this study. This work was supported by a Grant-in-Aid for Scientific Research on Priority Areas (C)(2) (No. 12218216) from the Ministry of Education, Culture, Sports, Science and Technology of Japan. The JACC Study was also supported by Grants-in-Aid for Scientific Research from the same Ministry (Nos. 63010074, 1010068, 2151065, 3151064, 4151063, 5151069, 6279102 and 11181101).

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Copyright information

© Springer Science+Business Media B.V. 2007

Authors and Affiliations

  • Takaaki Kondo
    • 1
  • Yoko Hori
    • 2
  • Hiroshi Yatsuya
    • 3
  • Koji Tamakoshi
    • 3
  • Hideaki Toyoshima
    • 3
  • Yoshikazu Nishino
    • 4
  • Nao Seki
    • 5
  • Yoshinori Ito
    • 6
  • Koji Suzuki
    • 7
  • Kotaro Ozasa
    • 8
  • Yoshiyuki Watanabe
    • 8
  • Masahiko Ando
    • 9
  • Kenji Wakai
    • 6
  • Akiko Tamakoshi
    • 6
  1. 1.Department of Medical TechnologyNagoya University School of Health SciencesHigashi-ku, NagoyaJapan
  2. 2.Department of NursingNagoya University School of Health SciencesHigashi-ku, NagoyaJapan
  3. 3.Department of Public Health/Health Information DynamicsNagoya University Graduate School of MedicineShowa-ku, NagoyaJapan
  4. 4.Division of Epidemiology, Department of Public Health and Forensic MedicineTohoku University Graduate School of MedicineAoba-ku, SendaiJapan
  5. 5.Division of Public Health, Department of Infectious Disease Control and International MedicineNiigata University Graduate School of Medical and Dental ScienceNiigataJapan
  6. 6.Department of Preventive Medicine/Biostatistics and Medical Decision MakingNagoya University Graduate School of MedicineShowa-ku, NagoyaJapan
  7. 7.Department of Public HealthFujita Health University School of Health SciencesKutsukake-cho, ToyoakeJapan
  8. 8.Department of Social Medicine and Cultural Sciences, Research Institute for Neurological Diseases and GeriatricsKyoto Prefectural University of MedicineKamigyo-ku, KyotoJapan
  9. 9.Health ServiceKyoto UniversitySakyo-ku, KyotoJapan

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