Cancer Causes & Control

, Volume 17, Issue 4, pp 481–482 | Cite as

Caution Needed in Fluoride and Osteosarcoma Study

  • Chester W. DouglassEmail author
  • Kaumudi Joshipura
Letter to the Editor

This issue of Cancer Causes and Controls includes a paper with results from an analysis of a subset of participants in our ongoing study of fluoride and osteosarcoma. The paper, “Age-specific fluoride exposure in drinking water and osteosarcoma”, presents a partial view of this ongoing study. We would like to advise the readers to be especially cautious when interpreting the findings of this paper for several reasons. The authors themselves have already raised a flag of caution in their final paragraph with the note that they are aware of additional findings from other incident cases that appear not to replicate the findings from the cases presented in their paper.

The Harvard School of Dental Medicine study of fluoride and osteosarcoma has been a 15-year collaboration among NIEHS, NCI, NIDCR, and Harvard. Two sets of cases have been collected each with their own control groups. The study started in 1992. The first set of cases was recruited from existing cases between 1989 and 1992,...


Fluoride Osteosarcoma Bone Specimen Fluoride Content Fluoride Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    The National Toxicology Program (NTP). Supplemental 2-year study of sodium fluoride in male F344 rats (CAS No. 7681–49–4)Google Scholar
  2. 2.
    National Toxicology Program (1990) Toxicology and carcinogenesis of sodium fluoride in F344 TN rats and B 6C3FL mice. Technical Report Services 393, NIH Publication No. 90–2848Google Scholar

Copyright information

© Springer 2006

Authors and Affiliations

  1. 1.Harvard School of Dental MedicineBostonUSA
  2. 2.Harvard School of Public HealthBostonUSA
  3. 3.University of Puerto Rico, Medical Sciences CampusSan JuanPuerto Rico

Personalised recommendations