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Cancer Causes & Control

, Volume 16, Issue 7, pp 839–850 | Cite as

Body Mass Index, Body Height, and Subsequent Risk of Colorectal Cancer in Middle-Aged and Elderly Japanese Men and Women: Japan Public Health Center-Based Prospective Study

  • Tetsuya OtaniEmail author
  • Motoki Iwasaki
  • Manami Inoue
  • Shoichiro Tsugane for the Japan Public Health Center-based Prospective Study Group
Article

Abstract

Objective

To investigate the association of body mass index (BMI) or body height with colorectal cancer incidence in a population-based prospective study.

Methods

We identified 986 (626 men and 360 women) newly diagnosed cases of colorectal cancer during the 9.4-year follow-up of a cohort consisting of 102,949 (49,158 male and 53,791 female) middle-aged and elderly Japanese.

Results

Lower BMI groups (lower than 23) were not associated with colorectal cancer compared with the 23–24.9 BMI group. Any categories of 25–26.9, 27–29.9, or 30 or more BMI were associated with an increased risk of colorectal cancer compared with the lower than 25 BMI (RR, 1.2 for 25–26.9, 1.4 for 27–29.9, and 1.5 for 30 or more; p for trend, 0.004) in men. These associations were more evident only in invasive-type cancer analysis. BMI was not associated with the risk of colorectal cancer in women. No significant association with height was obtained for either men or women.

Conclusions

The association of BMI with colorectal cancer was confirmed in a Japanese population as well as Western populations. Only invasive-cancer analysis suggested that BMI was important for tumor growth and proliferation. Approximately 6.7% of colorectal cancer was attributable to a BMI of 25 or higher in middle-aged and elderly Japanese men.

Keywords

body height body mass index colorectal cancer prospective study 

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Copyright information

© Springer 2005

Authors and Affiliations

  • Tetsuya Otani
    • 1
    Email author
  • Motoki Iwasaki
    • 1
  • Manami Inoue
    • 1
  • Shoichiro Tsugane for the Japan Public Health Center-based Prospective Study Group
  1. 1.Epidemiology and Prevention Division, Research Center for Cancer Prevention and ScreeningNational Cancer CenterTokyoJapan

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