Cancer Causes & Control

, Volume 16, Issue 8, pp 939–953 | Cite as

Occupational Exposures and Haematological Malignancies: Overview on Human Recent Data

  • Alexis Descatha
  • Arash Jenabian
  • Françoise Conso
  • Jacques Ameille



Occupational causes of haematological malignancies are relatively uncommon, under-studied and under-identified. They are also often unrecognized by clinicians. This review summarizes the principal epidemiologic studies on this topic.


We analyzed the recent relevant human data found in the Medline, the Pascal and the BDSP databases.


Benzene and ionizing radiation are the only agents conclusively demonstrated to be carcinogenic to the haematopoietic system. In particular, both exposures are strongly associated with acute myeloid leukaemia. Low doses of both may also be related to myeloid malignancies. Infectious agents and pesticides are also thought to induce lymphoproliferative cancers. Some studies show an association between haematological malignancies and low-frequency electromagnetic fields and organic solvents. All of these suspected occupational causes must be confirmed by further studies.


Better knowledge and understanding of occupational causes of haematological malignancies are necessary to improve their prevention and compensation.

Key words:

leukaemia lymphoma multiple myeloma myelodysplastic syndrome occupational disease. 


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  1. Nisse, C, Fenaux, P 2000

    Hémopathies malignes

    Pairon, JCBrochard, PLe Bourgeois, JPRuffié, P eds. Les Cancers ProfessionnelsMargaux OrangeParis497535
    Google Scholar
  2. Hardell, L, Eriksson, M 2003Is the decline of the increasing incidence of non-Hodgkin lymphoma in Sweden and other countries a result of cancer preventive measures?Environ Health Perspect11117041706PubMedGoogle Scholar
  3. Doll, R, Peto, R 1981The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States todayJ␣Natl Cancer Inst6611911308PubMedGoogle Scholar
  4. Nurminen, M, Karjalainen, A 2001Epidemiologic estimate of the proportion of fatalities related to occupational factors in FinlandScand J Work Environ Health27161213PubMedGoogle Scholar
  5. Descatha A, Jenabian A, Conso F, Ameille J (2003) Affections hématologiques malignes et activités professionnelles. Encycl Méd Chir Paris (Editions médicales et scientifiques Elsevier SAS. Tous droits réservés), Toxicologie–Pathologie professionnelle, 16530. A10: 1–12Google Scholar
  6. Yardley-Jones A, Gray A (2001) Haemopoietic effects of workplace exposures: anaemias, leukemias and lymphomas. In:␣Arnold, ed. Hunter’s Diseases of Occupations. London: pp. 901–913Google Scholar
  7. United Nations Scientific Committee on the Effects on Atomic Radiation (UNSCEAR) (2000) Sources and effects of ionizing radiation. United NationsGoogle Scholar
  8. Ritz, B, Morgenstern, H, Froines, J, Batts Young, B 1999Effects of exposure to external ionizing radiation on cancer mortality in nuclear workers monitored for radiation at Rocketdyne/Atomic InternationalAm J Ind Med352131CrossRefPubMedGoogle Scholar
  9. IARC1994Direct estimates of cancer mortality due to low doses of ionising radiation: an international study. IARC Study Group on Cancer Risk among Nuclear Industry WorkersLancet34410391043Google Scholar
  10. Schubauer-Berigan, MK, Wenzl, TB 2001Leukemia mortality among radiation-exposed workersOccup Med16271287PubMedGoogle Scholar
  11. Mohan, A, Hauptmann, M, Doody, M,  et al. 2000Mortality among radiologic technologists in the united states (1926–1997). 2nd Follow upAnn Epidemiol10480CrossRefGoogle Scholar
  12. Wang, JX, Zhang, LA, Li, BX,  et al. 2002Cancer incidence and risk estimation among medical X-ray workers in China, 1950–1995Health Phys82455466CrossRefPubMedGoogle Scholar
  13. Yoshinaga, S, Mabuchi, K, Sigurdson, AJ, Doody, MM, Ron, E 2004Cancer risks among radiologists and radiologic technologists: review of epidemiologic studiesRadiology233313321PubMedGoogle Scholar
  14. Muirhead, CR, Bingham, D, Haylock, RG,  et al. 2003Follow up of mortality and incidence of cancer 1952–1998 in men from the UK who participated in the UK’s atmospheric nuclear weapon tests and experimental programmesOccup Environ Med60165172CrossRefPubMedGoogle Scholar
  15. West, RR, Stafford, DA, Farrow, A, Jacobs, A 1995Occupational and environnemental exposures and myelodysplasia: a case–control studyLeuk Res19127139CrossRefPubMedGoogle Scholar
  16. Sont, WN, Zielinski, JM, Ashmore, JP,  et al. 2001First analysis of cancer incidence and occupational radiation exposure based on the National Dose Registry of CanadaAm J Epidemiol153309318CrossRefPubMedGoogle Scholar
  17. Wing, S, Richardson, D, Wolf, S, Mihlan, G, Crawford-Brown, D, Wood, J 2000A case–control study of multiple myeloma at four nuclear facilitiesAnn Epidemiol10144153CrossRefPubMedGoogle Scholar
  18. Baysson, H, Laurier, D, Tirmarche, M, Valenty, M, Giraud, JM 2000Epidemiological response to a suspected excess of cancer among a group of workers exposed to multiple radiological and chemical hazardsOccup Environ Med57188194CrossRefPubMedGoogle Scholar
  19. Hayes, RB, Songnian, Y, Dosemeci, M, Linet, M 2001Benzene and lymphohematopoietic malignancies in humansAm J Ind Med40117126CrossRefPubMedGoogle Scholar
  20. Wong, O 1995Risk of acute myeloid leukaemia and multiple myeloma in workers exposed to benzeneOccup Environ Med52380384PubMedGoogle Scholar
  21. Hayes, RB, Yin, SN, Dosemeci, M,  et al. 1997Benzene and the dose-related incidence of hematologic neoplasms in China. Chinese Academy of Preventive Medicine – National Cancer Institute Benzene Study GroupJ Natl Cancer Inst8910651071CrossRefPubMedGoogle Scholar
  22. Jakobsson, R, Ahlbom, A, Bellander, T, Lundberg, I 1993Acute myeloid leukemia among petrol station attendantsArch Environ Health48255259PubMedGoogle Scholar
  23. Guenel, P, Imbernon, E, Chevalier, A, Crinquand-Calastreng, A, Goldberg, M 2002Leukemia in relation to occupational exposures to benzene and other agents: a case–control study nested in a cohort of gas and electric utility workersAm J Ind Med428797CrossRefPubMedGoogle Scholar
  24. Glass, DC, Gray, CN, Jolley, DJ,  et al. 2003Leukemia risk associated with low-level benzene exposureEpidemiology14569577CrossRefPubMedGoogle Scholar
  25. Hunting, KL, Longbottom, H, Kalavar, SS, Stern, F, Schwartz, E, Welch, LS 1995Haematopoietic cancer mortality among vehicle mechanicsOccup Environ Med52673678PubMedGoogle Scholar
  26. Rinsky, RA, Hornung, RW, Silver, SR, Tseng, CY 2002Benzene exposure and hematopoietic mortality: a long-term epidemiologic risk assessmentAm J Ind Med42474480CrossRefPubMedGoogle Scholar
  27. Seniori, CA, Quinn, M, Consonni, D, Zappa, M 2003Exposure to benzene and risk of leukemia among shoe factory workersScand J Work Environ Health295159PubMedGoogle Scholar
  28. Wong, O, Harris, F, Rosamilia, K, Raabe, GK 2001An updated mortality study of workers at a petroleum refinery in Beaumont, Texas, 1945–1996J Occup Environ Med43384401PubMedGoogle Scholar
  29. Divine, BJ, Hartman, CM, Wendt, JK 1999Update of the Texaco mortality study 1947–1993: Part II. Analyses of specific causes of death for white men employed in refining, research, and petrochemicalsOccup Environ Med56174180PubMedGoogle Scholar
  30. Sathiakumar, N, Delzell, E, Cole, P, Brill, I, Frisch, J, Spivey, G 1995A case–control study of leukemia among petroleum workersJ Occup Environ Med3712691277PubMedGoogle Scholar
  31. Fabbro-Peray, P, Daures, JP, Rossi, JF 2001Environmental risk factors for non-Hodgkin’s lymphoma: a population-based case–control study in Languedoc-Roussillon, FranceCancer Causes Control12201212CrossRefPubMedGoogle Scholar
  32. O’Connor, SR, Farmer, PB, Lauder, I 1999Benzene and non-Hodgkin’s lymphomaJ Pathol189448453CrossRefPubMedGoogle Scholar
  33. Wong, O, Trent, L, Harris, F 1999Nested case–control study of leukaemia, multiple myeloma, and kidney cancer in a cohort of petroleum workers exposed to gasolineOccup Environ Med56217221PubMedGoogle Scholar
  34. Bergsagel, DE, Wong, O, Bergsagel, PL,  et al. 1999Benzene and multiple myeloma: appraisal of the scientific evidenceBlood9411741182PubMedGoogle Scholar
  35. Adegoke, OJ, Blair, A, Shu, XO,  et al. 2003Occupational history and exposure and the risk of adult leukemia in ShanghaiAnn Epidemiol13485494CrossRefPubMedGoogle Scholar
  36. Huebner, WW, Schnatter, AR, Nicolich, MJ, Jorgensen, G 1997Mortality experience of a young petrochemical industry cohort. 1979–1992 follow-up study of US-based employeesJ Occup Environ Med39970982CrossRefPubMedGoogle Scholar
  37. Lazarov, D, Waldron, HA, Pejin, D 2000Acute myeloid leukaemia and exposure to organic solvents – a case–control studyEur J Epidemiol16295301CrossRefPubMedGoogle Scholar
  38. Hunter, WJ, Henman, BA, Bartlett, DM, Le Geyt, IP 1993Mortality of professional chemists in England and Wales, 1965–1989Am J Ind Med23615627PubMedGoogle Scholar
  39. Albin, M, Bjork, J, Welinder, H,  et al. 2000Acute myeloid leukemia and clonal chromosome aberrations in relation to past exposure to organic solventsScand J Work Environ Health26482491PubMedGoogle Scholar
  40. Rigolin, GM, Cuneo, A, Roberti, MG,  et al. 1998Exposure to myelotoxic agents and myelodysplasia: case–control study and correlation with clinicobiological findingsBr J Haematol103189197CrossRefPubMedGoogle Scholar
  41. Ido, M, Nagata, C, Kawakami, N,  et al. 1996A case–control study of myelodysplastic syndromes among Japanese men and womenLeuk Res20727731CrossRefPubMedGoogle Scholar
  42. Blair, A, Linos, A, Stewart, PA,  et al. 1993Evaluation of risks for non-Hodgkin’s lymphoma by occupation and industry exposures from a case–control studyAm J Ind Med23301312PubMedGoogle Scholar
  43. Persson, B, Fredrikson, M 1999Some risk factors for non-Hodgkin’s lymphomaInt J Occup Med Environ Health12135142PubMedGoogle Scholar
  44. Tatham, L, Tolbert, P, Kjeldsberg, C 1997Occupational risk factors for subgroups of non-Hodgkin’s lymphomaEpidemiology8551558CrossRefPubMedGoogle Scholar
  45. Rego, MA, Sousa, CS, Kato, M, Carvalho, AB, Loomis, D, Carvalho, FM 2002Non-Hodgkin’s lymphomas and organic solventsJ Occup Environ Med44874881PubMedGoogle Scholar
  46. Blair, A, Hartge, P, Stewart, PA, McAdams, M, Lubin, J 1998Mortality and cancer incidence of aircraft maintenance workers exposed to trichloroethylene and other organic solvents and chemicals: extended follow upOccup Environ Med55161171PubMedGoogle Scholar
  47. Anttila, A, Pukkala, E, Sallmen, M, Hernberg, S, Hemminki, K 1995Cancer incidence among Finnish workers exposed to halogenated hydrocarbonsJ Occup Environ Med37797806PubMedGoogle Scholar
  48. Wartenberg, D, Reyner, D, Scott, CS 2000Trichloroethylene and cancer: epidemiologic evidenceEnviron Health Perspect108161176PubMedGoogle Scholar
  49. Raaschou-Nielsen, O, Hansen, J, McLaughlin, JK,  et al. 2003Cancer risk among workers at Danish companies using trichloroethylene: a cohort studyAm J Epidemiol15811821192CrossRefPubMedGoogle Scholar
  50. Axelson, O, Selden, A, Andersson, K, Hogstedt, C 1994Updated and expanded Swedish cohort study on trichloroethylene and cancer riskJ Occup Med36556562PubMedGoogle Scholar
  51. Hansen, J, Raaschou-Nielsen, O, Christensen, JM,  et al. 2001Cancer incidence among Danish workers exposed to trichloroethyleneJ Occup Environ Med43133139PubMedGoogle Scholar
  52. Huebner, WW, Chen, VW, Friedlander, BR,  et al. 2000Incidence of lymphohaematopoietic malignancies in a petrochemical industry cohort: 1983–1994 follow upOccup Environ Med57605614CrossRefPubMedGoogle Scholar
  53. Firth, HM, Herbison, GP, Cooke, KR, Fraser, J 1993Male cancer mortality by occupation: 1973–1986NZ Med J106328330Google Scholar
  54. Demers, PA, Vaughan, TL, Koepsell, TD,  et al. 1993A case–control study of multiple myeloma and occupationAm J Ind Med23629639PubMedGoogle Scholar
  55. Massoudi, BL, Talbott, EO, Day, RD, Swerdlow, SH, Marsh, GM, Kuller, LH 1997A case–control study of hematopoietic and lymphoid neoplasms: the role of work in the chemical industryAm J Ind Med312127CrossRefPubMedGoogle Scholar
  56. Boice, JD,Jr., Marano, DE, Fryzek, JP, Sadler, CJ, McLaughlin, JK 1999Mortality among aircraft manufacturing workersOccup Environ Med56581597PubMedGoogle Scholar
  57. Brown, LM, Moradi, T, Gridley, G, Plato, N, Dosemeci, M, Fraumeni, JF,Jr 2002Exposures in the painting trades and paint manufacturing industry and risk of cancer among men and women in SwedenJ Occup Environ Med44258264PubMedGoogle Scholar
  58. Wong, O, Raabe, GK 1997Multiple myeloma and benzene exposure in a multinational cohort of more than 250,000 petroleum workersRegul Toxicol Pharmacol26188199CrossRefPubMedGoogle Scholar
  59. Kheifets, LI, Afifi, AA, Buffler, PA, Zhang, ZW, Matkin, CC 1997Occupational electric and magnetic field exposure and leukemia. A meta-analysisJ Occup Environ Med3910741091CrossRefPubMedGoogle Scholar
  60. Villeneuve, PJ, Agnew, DA, Miller, AB, Corey, PN 2000Non-Hodgkin’s lymphoma among electric utility workers in Ontario: the evaluation of alternate indices of exposure to 60 Hz electric and magnetic fieldsOccup Environ Med57249257CrossRefPubMedGoogle Scholar
  61. Kheifets, LI, Gilbert, ES, Sussman, SS,  et al. 1999Comparative analyses of the studies of magnetic fields and cancer in electric utility workers: studies from France, Canada, and the United StatesOccup Environ Med56567574PubMedGoogle Scholar
  62. Harrington, JM, Nichols, L, Sorahan, T, Tongeren, M 2001Leukaemia mortality in relation to magnetic field exposure: findings from a study of United Kingdom electricity generation and transmission workers, 1973–1997Occup Environ Med58307314CrossRefPubMedGoogle Scholar
  63. Hakansson, N, Floderus, B, Gustavsson, P, Johansen, C, Olsen, JH 2002Cancer incidence and magnetic field exposure in industries using resistance welding in SwedenOccup Environ Med59481486CrossRefPubMedGoogle Scholar
  64. Morgan, RW, Kelsh, MA, Zhao, K, Exuzides, KA, Heringer, S, Negrete, W 2000Radiofrequency exposure and mortality from cancer of the brain and lymphatic/hematopoietic systemsEpidemiology11118127CrossRefPubMedGoogle Scholar
  65. Willett, EV, McKinney, PA, Fear, NT, Cartwright, RA, Roman, E 2003Occupational exposure to electromagnetic fields and acute leukaemia: analysis of a case–control studyOccup Environ Med60577583CrossRefPubMedGoogle Scholar
  66. Cano, MI, Pollan, M 2001Non-Hodgkin’s lymphomas and occupation in SwedenInt Arch Occup Environ Health74443449CrossRefPubMedGoogle Scholar
  67. Theriault, G, Goldberg, M, Miller, AB,  et al. 1994Cancer risks associated with occupational exposure to magnetic fields among electric utility workers in Ontario and Quebec, Canada, and France: 1970–1989Am J Epidemiol139550572PubMedGoogle Scholar
  68. Schroeder, JC, Savitz, DA 1997Lymphoma and multiple myeloma mortality in relation to magnetic field exposure among electric utility workersAm J Ind Med32392402CrossRefPubMedGoogle Scholar
  69. Band, PR, Le, ND, Fang, R, Gallagher, R 2004Identification of occupational cancer risks in British Columbia: a population-based case–control study of 769 cases of non-Hodgkin’s lymphoma analyzed by histopathology subtypesJ Occup Environ Med46479489PubMedGoogle Scholar
  70. Johansen, C 2004Electromagnetic fields and health effects–epidemiologic studies of cancer, diseases of the central nervous system and arrhythmia-related heart diseaseScand J Work Environ Health30130Google Scholar
  71. Bethwaite, P, McLean, D, Kennedy, J, Pearce, N 2001Adult-onset acute leukemia and employment in the meat industry: a New Zealand case–control studyCancer Causes Control12635643CrossRefPubMedGoogle Scholar
  72. Mele, A, Szklo, M, Visani, G,  et al. 1994Hair dye use and other risk factors for leukemia and pre-leukemia: a case–control study Italian Leukemia Study GroupAm J Epidemiol139609619PubMedGoogle Scholar
  73. Blair, A, Zahm, SH, Pearce, NE, Heineman, EF, Fraumeni, JF,Jr. 1992Clues to cancer etiology from studies of farmersScand J Work Environ Health18209215PubMedGoogle Scholar
  74. Blair, A, Zheng, T, Linos, A, Stewart, PA, Zhang, YW, Cantor, KP 2001Occupation and leukemia: a population-based case–control study in Iowa and MinnesotaAm J Ind Med40314CrossRefPubMedGoogle Scholar
  75. Zheng, T, Blair, A, Zhang, Y, Weisenburger, DD, Zahm, SH 2002Occupation and risk of non-Hodgkin’s lymphoma and chronic lymphocytic leukemiaJ Occup Environ Med44469474PubMedGoogle Scholar
  76. Lee, E, Burnett, CA, Lalich, N, Cameron, LL, Sestito, JP 2002Proportionate mortality of crop and livestock farmers in the United States, 1984–1993Am J Ind Med42410420CrossRefPubMedGoogle Scholar
  77. Kelleher, C, Newell, J, MacDonagh-White, C,  et al. 1998Incidence and occupational pattern of leukaemias, lymphomas, and testicular tumours in western Ireland over an 11-year periodJ␣Epidemiol Commun Health52651656Google Scholar
  78. Cocco, P, Blair, A, Congia, P, Saba, G, Ecca, AR, Palmas, C 1997Long-term health effects of the occupational exposure to DDT. A preliminary reportAnn NY Acad Sci837246256PubMedGoogle Scholar
  79. Amadori, D, Nanni, O, Falciani, F, Saragoni, A 1995Chronic lymphocytic leukemia and non-Hodgkin’s lymphomas by histological type in farming-animal breeding worker: a popuplation case–control study on job titlesOccup Environ Med52374379PubMedGoogle Scholar
  80. Baker, P, Inskip, H, Coggon, D 1999Lymphatic and hematopoietic cancer in teachersScand J Work Environ Health25517Google Scholar
  81. McDuffie, HH, Pahwa, P, Spinelli, JJ,  et al. 2002Canadian male farm residents, pesticide safety handling practices, exposure to animals and non-Hodgkin’s lymphoma (NHL)Am J Ind Med Suppl25461CrossRefGoogle Scholar
  82. Fritschi, L, Johnson, KC, Kliewer, EV, Fry, R 2002Animal-related occupations and the risk of leukemia, myeloma, and non-Hodgkin’s lymphoma in CanadaCancer Causes Control13563571CrossRefPubMedGoogle Scholar
  83. Khuder, SA, Schaub, EA, Keller-Byrne, JE 1998Meta-analyses of non-Hodgkin’s lymphoma and farmingScand J Work Environ Health24255261PubMedGoogle Scholar
  84. Khuder, SA, Mutgi, AB, Schaub, EA, Tano, BD 1999Meta-analysis of Hodgkin’s disease among farmersScand J Work Environ Health25436441PubMedGoogle Scholar
  85. Cerhan, JR, Cantor, KP, Williamson, K, Lynch, CF, Torner, JC, Burmeister, LF 1998Cancer mortality among Iowa farmers: recent results, time trends, and lifestyle factors (United States)Cancer Causes Control9311319CrossRefPubMedGoogle Scholar
  86. McCunney, RJ 1999Hodgkin’s disease, work, and the environment. A reviewJ Occup Environ Med413646CrossRefPubMedGoogle Scholar
  87. Miligi, L, Seniori, CA, Crosignani, P,  et al. 1999Occupational, environmental, and life-style factors associated with the risk of hematolymphopoietic malignancies in womenAm J Ind Med366069CrossRefPubMedGoogle Scholar
  88. Metayer, C, Johnson, ES, Rice, JC 1998Nested case–control study of tumors of the hemopoietic and lymphatic systems among workers in the meat industryAm J Epidemiol147727738PubMedGoogle Scholar
  89. Baris, D, Zahm, SH, Cantor, KP, Blair, A 1998Agricultural use of DDT and risk of non-Hodgkin’s lymphoma: pooled analysis of three case–control studies in the United StatesOccup Environ Med55522527PubMedGoogle Scholar
  90. Zheng, T, Zahm, SH, Cantor, KP, Weisenburger, DD, Zhang, Y, Blair, A 2001Agricultural exposure to carbamate pesticides and risk of non-Hodgkin lymphomaJ Occup Environ Med43641649PubMedGoogle Scholar
  91. Hardell, L, Eriksson, M, Degerman, A 1994Exposure to phenoxyacetic acids, chlorophenols, or organic solvents in relation to histopathology, stage, and anatomical localization of non-Hodgkin’s lymphomaCancer Res5423862389PubMedGoogle Scholar
  92. Thorn, A, Gustavsson, P, Sadigh, J, Westerlund-Hannestrand, B, Hogstedt, C 2000Mortality and cancer incidence among Swedish lumberjacks exposed to phenoxy herbicidesOccup Environ Med57718720CrossRefPubMedGoogle Scholar
  93. Zahm, SH 1997Mortality study of pesticide applicators and other employees of a lawn care service companyJ Occup Environ Med3910551067CrossRefPubMedGoogle Scholar
  94. Miligi, L, Costantini, AS, Bolejack, V,  et al. 2003Non-Hodgkin’s lymphoma, leukemia, and exposures in agriculture: results from the Italian multicenter case–control studyAm J Ind Med44627636CrossRefPubMedGoogle Scholar
  95. De Roos, AJ, Zahm, SH, Cantor, KP,  et al. 2003Integrative assessment of multiple pesticides as risk factors for non-Hodgkin’s lymphoma among menOccup Environ Med60E11CrossRefPubMedGoogle Scholar
  96. Gambini, GF, Mantovani, C, Pira, E, Piolatto, PG, Negri, E 1997Cancer mortality among rice growers in Novara Province, northern ItalyAm J Ind Med31435441CrossRefPubMedGoogle Scholar
  97. Kato, I, Watanabe-Meserve, H, Koenig, KL,  et al. 2004Pesticide product use and risk of non-Hodgkin lymphoma in womenEnviron Health Perspect11212751281PubMedGoogle Scholar
  98. Acquavella, JF, Delzell, E, Cheng, H, Lynch, CF, Johnson, G 2004Mortality and cancer incidence among alachlor manufacturing workers 1968–1999Occup Environ Med61680685CrossRefPubMedGoogle Scholar
  99. Lee, WJ, Hoppin, JA, Blair, A,  et al. 2004Cancer incidence among pesticide applicators exposed to alachlor in the Agricultural Health StudyAm J Epidemiol159373380CrossRefPubMedGoogle Scholar
  100. Rusiecki, JA, De Roos, A, Lee, WJ,  et al. 2004Cancer incidence among pesticide applicators exposed to atrazine in the Agricultural Health StudyJ Natl Cancer Inst9613751382PubMedGoogle Scholar
  101. Bertazzi, PA, Consonni, D, Bachetti, S,  et al. 2001Health effects of dioxin exposure: a 20-year mortality studyAm J Epidemiol15310311044CrossRefPubMedGoogle Scholar
  102. Swaen, GM, Vliet, C, Slangen, JJ, Sturmans, F 1992Cancer mortality among licensed herbicide applicatorsScand J Work Environ Health18201204PubMedGoogle Scholar
  103. Nanni, O, Falcini, F, Buiatti, E,  et al. 1998Multiple myeloma and work in agriculture: results of a case–control study in Forli, ItalyCancer Causes Control9277283CrossRefPubMedGoogle Scholar
  104. Nordstrom, M, Hardell, L, Magnuson, A, Hagberg, H, Rask-Andersen, A 1998Occupational exposures, animal exposure and smoking as risk factors for hairy cell leukaemia evaluated in a case–control studyBr J Cancer7720482052PubMedGoogle Scholar
  105. Clavel, J, Mandereau, L, Cordier, S,  et al. 1995Hairy cell leukaemia, occupation, and smokingBr J Haematol91154161PubMedGoogle Scholar
  106. Clavel, J, Hemon, D, Mandereau, L, Delemotte, B, Severin, F, Flandrin, G 1996Farming, pesticide use and hairy-cell leukemiaScand J Work Environ Health22285293PubMedGoogle Scholar
  107. Divine, BJ, Hartman, CM 2001A cohort mortality study among workers at a 1,3 butadiene facilityChem Biol Interact135–136535553CrossRefPubMedGoogle Scholar
  108. Sathiakumar, N, Delzell, E, Hovinga, M,  et al. 1998Mortality from cancer and other causes of death among synthetic rubber workersOccup Environ Med55230235PubMedGoogle Scholar
  109. Delzell, E, Macaluso, M, Sathiakumar, N, Matthews, R 2001Leukemia and exposure to 1,3-butadiene, styrene and dimethyldithiocarbamate among workers in the synthetic rubber industryChem Biol Interact135–136515534CrossRefPubMedGoogle Scholar
  110. Kogevinas, M, Sala, M, Boffetta, P, Kazerouni, N, Kromhout, H, Hoar-Zahm, S 1998Cancer risk in the rubber industry: a review of the recent epidemiological evidenceOccup Environ Med55112PubMedGoogle Scholar
  111. Santos-Burgoa, C, Matanoski, GM, Zeger, S, Schwartz, L 1992Lymphohematopoietic cancer in styrene–butadiene polymerization workersAm J Epidemiol136843854PubMedGoogle Scholar
  112. Tsai, SP, Wendt, JK, Ransdell, JD 2001A mortality, morbidity, and hematology study of petrochemical employees potentially exposed to 1,3-butadiene monomerChem Biol Interact135–136555567CrossRefPubMedGoogle Scholar
  113. Kogevinas, M, Ferro, G, Andersen, A,  et al. 1994Cancer mortality in a historical cohort study of workers exposed to styreneScand J Work Environ Health20251261PubMedGoogle Scholar
  114. Ruder, AM, Ward, EM, Dong, M, Okun, AH, Davis-King, K 2004Mortality patterns among workers exposed to styrene in the reinforced plastic boatbuilding industry: an updateAm J Ind Med45165176CrossRefPubMedGoogle Scholar
  115. Stayner, L, Steenland, K, Greife, A,  et al. 1993Exposure-response analysis of cancer mortality in a cohort of workers exposed to ethylene oxideAm J Epidemiol138787798PubMedGoogle Scholar
  116. Shore, RE, Gardner, MJ, Pannett, B 1993Ethylene oxide: an assessment of epidemiological evidence on carcinogenicityBr J Ind Med50971997PubMedGoogle Scholar
  117. Coggon, D, Harris, EC, Poole, J, Palmer, KT 2004Mortality of workers exposed to ethylene oxide: extended follow up of a British cohortOccup Environ Med61358362CrossRefPubMedGoogle Scholar
  118. Steenland, K, Stayner, L, Deddens, J 2004Mortality analyses in a cohort of 18,235 ethylene oxide exposed workers: follow up extended from 1987 to 1998Occup Environ Med6127PubMedGoogle Scholar
  119. Skov, T 1993Handling antineoplastic drugs in the European Community countriesEur J Cancer Prev24346PubMedGoogle Scholar
  120. Vecchio, D, Sasco, AJ, Cann, CI 2003Occupational risk in health care and researchAm J Ind Med43369397CrossRefPubMedGoogle Scholar
  121. Lynge, E 1994Danish Cancer Registry as a resource for occupational researchJ Occup Med3611691173Google Scholar
  122. Sessink, PJ, Kroese, ED, Kranen, HJ, Bos, RP 1995Cancer risk assessment for health care workers occupationally exposed to cyclophosphamideInt Arch Occup Environ Health67317323CrossRefPubMedGoogle Scholar
  123. Sessink, PJ, Bos, RP 1999Drugs hazardous to healthcare workers. Evaluation of methods for monitoring occupational exposure to cytostatic drugsDrug Saf20347359PubMedGoogle Scholar
  124. Collins, JJ 2004Formaldehyde exposure and leukaemiaOccup Environ Med61875876CrossRefPubMedGoogle Scholar
  125. Hauptmann, M, Lubin, JH, Stewart, PA, Hayes, RB, Blair, A 2003Mortality from lymphohematopoietic malignancies among workers in formaldehyde industriesJ Natl Cancer Inst9516151623PubMedGoogle Scholar
  126. Pinkerton, LE, Hein, MJ, Stayner, LT 2004Mortality among a cohort of garment workers exposed to formaldehyde: an updateOccup Environ Med61193200CrossRefPubMedGoogle Scholar
  127. Coggon, D, Harris, EC, Poole, J, Palmer, KT 2003Extended follow-up of a cohort of british chemical workers exposed to formaldehydeJ Natl Cancer Inst9516081615PubMedGoogle Scholar
  128. McLaughlin, JK 1994Formaldehyde and cancer: a critical reviewInt Arch Occup Environ Health66295301CrossRefPubMedGoogle Scholar
  129. Lee, WJ, Baris, D, Jarvholm, B, Silverman, DT, Bergdahl, IA, Blair, A 2003Multiple myeloma and diesel and other occupational exposures in swedish construction workersInt J Cancer107134138CrossRefPubMedGoogle Scholar
  130. Sonoda, T, Nagata, Y, Mori, M, Ishida, T, Imai, K 2001Meta-analysis of multiple myeloma and benzene exposureJ Epidemiol11249254PubMedGoogle Scholar
  131. La Vecchia, C, Tavani, A 2002Hair dyes and lymphoid neoplasms: an updateEur J Cancer Prev11409412CrossRefPubMedGoogle Scholar
  132. Hansen, J, Olsen, JH 1994Cancer morbidity among Danish female pharmacy techniciansScand J Work Environ Health202226PubMedGoogle Scholar
  133. Shaham, J, Gurvich, R, Kneshet, Y 2003Cancer incidence among laboratory workers in biomedical research and routine laboratories in Israel: Part II-nested case–control studyAm J Ind Med44611626CrossRefPubMedGoogle Scholar
  134. Shaham, J, Gurvich, R, Kneshet, Y 2003Cancer incidence among laboratory workers in biomedical research and routine laboratories in Israel: Part I-the cohort studyAm J Ind Med44600610CrossRefPubMedGoogle Scholar
  135. Rachet, B, Partanen, T, Kauppinen, T, Sasco, AJ 2000Cancer risk in laboratory workers: an emphasis on biological researchAm J Ind Med38651665CrossRefPubMedGoogle Scholar
  136. Cordier, S, Mousel, ML, Le Goaster, C,  et al. 1995Cancer risk among workers in biomedical researchScand J Work Environ Health21450459PubMedGoogle Scholar
  137. Kauppinen, T, Pukkala, E, Saalo, A, Sasco, AJ 2003Exposure to chemical carcinogens and risk of cancer among Finnish laboratory workersAm J Ind Med44343350CrossRefPubMedGoogle Scholar
  138. Baris, D, Zahm, SH 2000Epidemiology of lymphomasCurr Opin Oncol12383394CrossRefPubMedGoogle Scholar
  139. Bukowski, JA, Huebner, WW, Schnatter, AR, Wojcik, NC 2003An analysis of the risk of B-lymphocyte malignancies in industrial cohortsJ Toxicol Environ Health A66581597PubMedGoogle Scholar
  140. Lie, JA, Kjaerheim, K 2003Cancer risk among female nurses: a literature reviewEur J Cancer Prev12517526CrossRefPubMedGoogle Scholar
  141. Nilsson, T, Hoglund, M, Lenhoff, S,  et al. 2003A pooled analysis of karyotypic patterns, breakpoints and imbalances in 783 cytogenetically abnormal multiple myelomas reveals frequently involved chromosome segments as well as significant age- and sex-related differencesBr J Haematol120960969CrossRefPubMedGoogle Scholar
  142. Bruske-Hohlfeld, I 1999Occupational cancer in GermanyEnviron Health Perspect107253258PubMedGoogle Scholar
  143. Merler, E, Vineis, P, Alhaique, D, Miligi, L 1999Occupational cancer in ItalyEnviron Health Perspect107259271PubMedGoogle Scholar
  144. Gun, RT, Pratt, NL, Griffith, EC, Adams, GG, Bisby, JA, Robinson, KL 2004Update of a prospective study of mortality and cancer incidence in the Australian petroleum industryOccup Environ Med61150156CrossRefPubMedGoogle Scholar
  145. Gustavsson, P, Reuterwall, C, Sadigh, J, Soderholm, M 1999Mortality and cancer incidence among laboratory technicians in medical research and routine laboratories (Sweden)Cancer Causes Control105964CrossRefPubMedGoogle Scholar
  146. Eisen, EA, Bardin, J, Gore, R, Woskie, SR, Hallock, MF, Monson, RR 2001Exposure-response models based on extended follow-up of a cohort mortality study in the automobile industryScand J Work Environ Health27240249PubMedGoogle Scholar
  147. Savitz, DA, Cai, J, Wijngaarden, E,  et al. 2000Case–cohort analysis of brain cancer and leukemia in electric utility workers using a refined magnetic field job-exposure matrixAm J Ind Med38417425CrossRefPubMedGoogle Scholar
  148. Fleming, LE, Bean, JA, Rudolph, M, Hamilton, K 1999Mortality in a cohort of licenced pesticide applicators in FloridaOccup Environ Med561421PubMedGoogle Scholar
  149. Bloemen, LJ, Youk, A, Bradley, TD, Bodner, KM, Marsh, G 2004Lymphohaematopoietic cancer risk among chemical workers exposed to benzeneOccup Environ Med61270274CrossRefPubMedGoogle Scholar
  150. Lewis, RJ, Gamble, JF, Jorgensen, G 2000Mortality among three refinery/petrochemical plant cohorts. I. 1970–1982 active/terminated workersJ Occup Environ Med42721729PubMedGoogle Scholar
  151. Lagorio, S, Forastiere, F, Iavarone, I,  et al. 1994Mortality of filling station attendantsScand J Work Environ Health20331338PubMedGoogle Scholar
  152. Collingwood, KW, Raabe, GK, Wong, O 1996An updated cohort mortality study of workers at a northeastern United States petroleum refineryInt Arch Occup Environ Health68277288CrossRefPubMedGoogle Scholar
  153. Rafnsson, V 2001Incidence of cancer among bookbinders, printers, photoengravers, and typesettersOccup Environ Med58523527CrossRefPubMedGoogle Scholar
  154. Mao, Y, Hu, J, Ugnat, AM, White, K 2000Non-Hodgkin’s lymphoma and occupational exposure to chemicals in Canada. Canadian Cancer Registries Epidemiology Research GroupAnn Oncol116973CrossRefGoogle Scholar
  155. Demers, PA, Boffetta, P 1998Cancer risk from occupational exposure to wood dust: pooled analysis of epidemiologic studiesOccup Environ Med582430Google Scholar
  156. Burns, CJ, Beard, KK, Cartmill, JB 2001Mortality in chemical workers potentially exposed to 2,4-dichlorophenoxyacetic acid (2,4-D) 1945–1994: an updateOccup Environ Med582430CrossRefPubMedGoogle Scholar
  157. MacLennan, PA, Delzell, E, Sathiakumar, N, Myers, SL 2003Mortality among triazine herbicide manufacturing workersJ␣Toxicol Environ Health A66501517CrossRefPubMedGoogle Scholar
  158. Garabedian, MJ, Hoppin, JA, Tolbert, PE, Herrick, RF, Brann, EA 1999Occupational chlorophenol exposure and non-Hodgkin’s lymphomaJ Occup Environ Med41267272CrossRefPubMedGoogle Scholar
  159. Pukkala, E, Notkola, V 1997Cancer incidence among Finnish farmers, 1979–1993Cancer Causes Control82533CrossRefPubMedGoogle Scholar
  160. Pahwa, P, McDuffie, HH, Dosman, JA,  et al. 2003Exposure to animals and selected risk factors among Canadian farm residents with Hodgkin’s disease, multiple myeloma, or soft tissue sarcomaJ Occup Environ Med45857868PubMedGoogle Scholar
  161. Lundberg, I, Milatou-Smith, R 1998Mortality and cancer incidence among Swedish paint industry workers with long-term exposure to organic solventsScand J Work Environ Health24270275PubMedGoogle Scholar
  162. Robinson, CF, Walker, JT 1999Cancer mortality among women employed in fast-growing U.S. occupationsAm J Ind Med36186192CrossRefPubMedGoogle Scholar
  163. Baris, D, Silverman, DT, Brown, LM,  et al. 2004Occupation, pesticide exposure and risk of multiple myelomaScand J Work Environ Health30215222PubMedGoogle Scholar

Copyright information

© Springer 2005

Authors and Affiliations

  • Alexis Descatha
    • 1
  • Arash Jenabian
    • 2
  • Françoise Conso
    • 3
  • Jacques Ameille
    • 1
  1. 1.Unité de pathologie professionnelle et de santé au travailHôpital R. PoincaréGarchesFrance
  2. 2.Service de cancérologie médicaleHôpital Européen Georges PompidouParisFrance
  3. 3.Service de pathologie professionnelleHôpital CochinParisFrance

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