Cancer Causes & Control

, Volume 16, Issue 6, pp 725–733

Dietary patterns and breast cancer risk: results from three cohort studies in the DIETSCAN project

  • Satu Männistö
  • L. Beth Dixon
  • Helena F. Balder
  • Mikko J. Virtanen
  • Vittorio Krogh
  • Bahram Rashid Khani
  • Franco Berrino
  • Piet A. van den Brandt
  • Anne M. Hartman
  • Pirjo Pietinen
  • Frans Tan
  • Alicja Wolk
  • R. Alexandra Goldbohm
Article

Abstract

Objective: Only a few consistent findings on individual foods or nutrients that influence breast cancer risk have emerged thus far. Since people do not consume individual foods but certain combinations of them, the analysis of dietary patterns may offer an additional aspect for assessing associations between diet and diseases such as breast cancer. It is also important to examine whether the relationships between dietary patterns and breast cancer risk are consistent across populations.

Methods: We examined the risk of breast cancer with two dietary patterns, identified as “Vegetables” (VEG) and “Pork, Processed Meat, Potatoes” (PPP), common to all cohorts of the DIETSCAN project. During 7 to 13 years of follow-up, three of the cohorts – the Netherlands Cohort Study on diet and cancer (NLCS), the Swedish Mammography Cohort (SMC), and the Ormoni e Dieta nella Eziologia dei Tumori (Italy-ORDET) – provided data on 3271 breast cancer cases with complete information on their baseline diet measured by a validated food frequency questionnaire.

Results: After adjustment for potential confounders, VEG was not associated with the risk of breast cancer across all cohorts. PPP was also not associated with the risk of breast cancer in SMC and ORDET, but a high PPP score tended to be inversely associated with breast cancer in the NLCS study (RR  = 0.69; 95% CI, 0.52–0.92, highest versus lowest quartile). PPP differed in one aspect between the cohorts: butter loaded positively on the pattern in all cohorts except NLCS, in which butter loaded negatively and appeared to be substituted by low-fat margarine loading positively.

Conclusion: In general, the dietary patterns showed consistent results across the three cohorts except for the possible protective effect of PPP in the NLCS cohort, which could be explained by a difference in that pattern for NLCS. The results supported the suggestion derived from traditional epidemiology that relatively recent diet may not have an important role in the etiology of breast cancer.

Keywords

breast cancer diet dietary pattern factor analysis principal component analysis. 

Abbreviations

ATBC

Alpha-Tocopherol Beta-Carotene Cancer Prevention Study

DIETSCAN

DIETary patternS and CANcer in four European countries

FFQ

Food frequency questionnaire

NLCS

Netherlands Cohort Study on Diet and Cancer

ORDET

Ormoni e Dieta nella Eziologia dei Tumori

SMC

Swedish Mammography Cohort

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Copyright information

© Springer 2005

Authors and Affiliations

  • Satu Männistö
    • 1
  • L. Beth Dixon
    • 2
    • 7
  • Helena F. Balder
    • 3
  • Mikko J. Virtanen
    • 1
  • Vittorio Krogh
    • 4
  • Bahram Rashid Khani
    • 5
  • Franco Berrino
    • 4
  • Piet A. van den Brandt
    • 6
  • Anne M. Hartman
    • 7
  • Pirjo Pietinen
    • 1
  • Frans Tan
    • 8
  • Alicja Wolk
    • 5
  • R. Alexandra Goldbohm
    • 3
  1. 1.Department of Epidemiology and Health PromotionNational Public Health InstituteHelsinkiFinland
  2. 2.Department of Nutrition, Food studies and Public HealthNew York UniversityNew YorkUSA
  3. 3.Department of Nutritional EpidemiologyTNO Nutrition and Food ResearchZeistThe Netherlands
  4. 4.Epidemiology UnitInstituto Nazionale per lo Studio e la Cura dei TumoriMilanItaly
  5. 5.Institute of Environmental EpidemiologyKarolinska InstitutetStockholmSweden
  6. 6.Department of EpidemiologyMaastricht UniversityMaastrichtThe Netherlands
  7. 7.Division of Cancer Control and Population SciencesNational Cancer InstituteBethesdaUSA
  8. 8.Department of Methodology and StatisticsMaastricht UniversityMaastrichtThe Netherlands

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