Cancer Causes & Control

, Volume 16, Issue 6, pp 743–748 | Cite as

Maternal hair dye use and risk of neuroblastoma in offspring*

  • Erin E. McCall
  • Andrew F. OlshanEmail author
  • Julie L. Daniels


Objective: Studies have suggested an association between maternal hair dye use and elevated risk of childhood cancer, including neuroblastoma. We analyzed data from a large case–control study to investigate the relationship between maternal hair dye use around pregnancy and risk of neuroblastoma in offspring.

Methods: Cases were children with neuroblastoma diagnosed between 1992 and 1994 at hospitals in the United States and Canada participating in the Children’s Cancer Group or the Pediatric Oncology Group. Random-digit dialing was used to identify one matched control for each case. Information on hair dye use was gathered from telephone interviews of 538 case and 504 control mothers.

Results: Use of any hair dye in the month before and/or during pregnancy was associated with a moderately increased risk of neuroblastoma (adjusted odds ratio (OR) = 1.6; 95% confidence interval (CI) = 1.2–2.2). Temporary hair dye use (OR = 2.0, CI  = 1.1–3.7) was more strongly associated with neuroblastoma than use of permanent hair dye (OR = 1.4, CI  = 1.0–2.0).

Conclusion: Although the results of this study provide evidence of an association between maternal hair dye use and neuroblastoma, further research is necessary to evaluate effects by method of hair dye application, color, and chemical composition.


neuroblastoma hair dyes epidemiology child case–control studies. 


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  1. 1.
    Little, J 1999Epidemiology of Childhood CancerInternational Agency for Research on CancerLyon1, 5152Google Scholar
  2. 2.
    Goodman, MT, Gurney, JG, Smith, MA, Olshan, AF 1999Sympathetic nervous system tumorsRies, LAGSmith, MAGurney, JGLinet, MTamra, TYoung, JLBunin, GR eds. Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975–1995National Cancer InstituteBethesda, MD6572NIH Pub. No. 99-4649Google Scholar
  3. 3.
    Olshan, AF, Bunin, GR 2000Epidemiology of NeuroblastomaBrodeur, GMSawada, TTsuchida, YVoute, PA eds. NeuroblastomaElsevierAmsterdam3339Google Scholar
  4. 4.
    Holly, EA, Bracci, PM, Hong, MK, Mueller, BA, Preston-Martin, S 2002West Coast study of childhood brain tumours and maternal use of hair-colouring productsPaediatr Perinat Epidemiol16226235CrossRefPubMedGoogle Scholar
  5. 5.
    Kramer, S, Ward, E, Meadows, AT, Malone, KE 1987Medical and drug risk factors associated with neuroblastoma: a case–control studyJ Natl Cancer Inst78797804PubMedGoogle Scholar
  6. 6.
    Bunin, GR, Buckley, JD, Boesel, CP, Rorke, LB, Meadows, AT 1994Risk factors for astrocytic glioma and primitive neuroectodermal tumor of the brain in young children: a report from the Children’s Cancer GroupCancer Epidemiol Biomarkers Prev3197204PubMedGoogle Scholar
  7. 7.
    Bunin, GR, Kramer, S, Marrero, O, Meadows, AT 1987Gestational risk factors for Wilms’ tumor: results of a case–control studyCancer Res4729722977PubMedGoogle Scholar
  8. 8.
    International Agency for Research on Cancer (1993) Occupational Exposures of Hairdressers and Barbers and Personal Use of Hair Colourants; Some Hair Dyes, Cosmetic Colourants, Industrial Dyestuffs and Aromatic Amines. Lyon, France: International Agency for Research on Cancer, pp. 43–53, 63–64, 93–94, 129–212.Google Scholar
  9. 9.
    Nohynek, GJ, Fautz, R, Benech-Kieffer, F, Toutain, H 2004Toxicity and human health risk of hair dyesFood Chem Toxicol42517543CrossRefPubMedGoogle Scholar
  10. 10.
    Tomatis, L 1989Overview of perinatal and multigeneration carcinogenesisNapalkov, NPRice, JMTomatis, LYamasaki, H eds. Perinatal and Multigeneration CarcinogenesisInternational Agency for Research on Cancer Lyon, France115Google Scholar
  11. 11.
    Olshan, AF, DeRoos, AJ, Teschke, K,  et al. 1999Neuroblastoma and parental occupationCancer Causes Control10539549CrossRefPubMedGoogle Scholar
  12. 12.
    Olshan, AF, Smith, J, Cook, MN,  et al. 1999Hormone and fertility drug use and the risk of neuroblastoma: a report from the Children’s Cancer Group and the Pediatric Oncology GroupAm J Epidemiol150930938PubMedGoogle Scholar
  13. 13.
    Carey, FA 1996Organic Chemistry3University of VirginiaMcGraw-Hill927928Google Scholar
  14. 14.
    Lijinsky, W 1999N-Nitroso compounds in the dietMutat Res443129138PubMedGoogle Scholar
  15. 15.
    Brodeur, GM, Maris, JM, Yamashiro, DJ, Hogarty, MD, White, PS 1997Biology and genetics of human neuroblastomasJ Pediatr Hematol Oncol1993101CrossRefPubMedGoogle Scholar
  16. 16.
    Schwab, M 2004MYCN in neuronal tumoursCancer Lett204179187CrossRefPubMedGoogle Scholar
  17. 17.
    Shapiro, DN, Valentine, MB, Rowe, ST,  et al. 1993Detection of N-myc gene amplification by fluorescence in situ hybridization: diagnostic utility for neuroblastomaAm J Pathol14213391346PubMedGoogle Scholar
  18. 18.
    Brodeur, GM, Castleberry, RP 1993NeuroblastomaPizzo, PAPoplack, DG eds. Principles and Practice of Pediatric OncologyJB Lippincott CompanyPhiladelphia, PA739768Google Scholar
  19. 19.
    Rothman, KJ, Greeland, S 1998Modern Epidemiology2Lippincott Williams & WilkinsPhiladelphia, PA126127Google Scholar
  20. 20.
    Infante-Rivard, C, Jacques, L 2000Empirical study of parental recall biasAm J Epidemiol152480486PubMedGoogle Scholar
  21. 21.
    Schuz, J, Spector, LG, Ross, JA 2003Bias in studies of parental self-reported occupational exposure and childhood cancerAm J Epidemiol158710716CrossRefPubMedGoogle Scholar
  22. 22.
    Drews, CD, Kraus, JF, Greenland, S 1990Recall bias in a case–control study of sudden infant death syndromeInt J Epidemiol19405411PubMedGoogle Scholar

Copyright information

© Springer 2005

Authors and Affiliations

  • Erin E. McCall
    • 1
  • Andrew F. Olshan
    • 1
    Email author
  • Julie L. Daniels
    • 1
  1. 1.Department of Epidemiology, School of Public HealthUniversity of North CarolinaChapel HillUSA

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