Maternal hair dye use and risk of neuroblastoma in offspring*
- 401 Downloads
Objective: Studies have suggested an association between maternal hair dye use and elevated risk of childhood cancer, including neuroblastoma. We analyzed data from a large case–control study to investigate the relationship between maternal hair dye use around pregnancy and risk of neuroblastoma in offspring.
Methods: Cases were children with neuroblastoma diagnosed between 1992 and 1994 at hospitals in the United States and Canada participating in the Children’s Cancer Group or the Pediatric Oncology Group. Random-digit dialing was used to identify one matched control for each case. Information on hair dye use was gathered from telephone interviews of 538 case and 504 control mothers.
Results: Use of any hair dye in the month before and/or during pregnancy was associated with a moderately increased risk of neuroblastoma (adjusted odds ratio (OR) = 1.6; 95% confidence interval (CI) = 1.2–2.2). Temporary hair dye use (OR = 2.0, CI = 1.1–3.7) was more strongly associated with neuroblastoma than use of permanent hair dye (OR = 1.4, CI = 1.0–2.0).
Conclusion: Although the results of this study provide evidence of an association between maternal hair dye use and neuroblastoma, further research is necessary to evaluate effects by method of hair dye application, color, and chemical composition.
Keywordsneuroblastoma hair dyes epidemiology child case–control studies.
Unable to display preview. Download preview PDF.
- 1.Little, J 1999Epidemiology of Childhood CancerInternational Agency for Research on CancerLyon1, 5152Google Scholar
- 2.Goodman, MT, Gurney, JG, Smith, MA, Olshan, AF 1999Sympathetic nervous system tumorsRies, LAGSmith, MAGurney, JGLinet, MTamra, TYoung, JLBunin, GR eds. Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975–1995National Cancer InstituteBethesda, MD6572NIH Pub. No. 99-4649Google Scholar
- 3.Olshan, AF, Bunin, GR 2000Epidemiology of NeuroblastomaBrodeur, GMSawada, TTsuchida, YVoute, PA eds. NeuroblastomaElsevierAmsterdam3339Google Scholar
- 8.International Agency for Research on Cancer (1993) Occupational Exposures of Hairdressers and Barbers and Personal Use of Hair Colourants; Some Hair Dyes, Cosmetic Colourants, Industrial Dyestuffs and Aromatic Amines. Lyon, France: International Agency for Research on Cancer, pp. 43–53, 63–64, 93–94, 129–212.Google Scholar
- 10.Tomatis, L 1989Overview of perinatal and multigeneration carcinogenesisNapalkov, NPRice, JMTomatis, LYamasaki, H eds. Perinatal and Multigeneration CarcinogenesisInternational Agency for Research on Cancer Lyon, France115Google Scholar
- 13.Carey, FA 1996Organic Chemistry3University of VirginiaMcGraw-Hill927928Google Scholar
- 18.Brodeur, GM, Castleberry, RP 1993NeuroblastomaPizzo, PAPoplack, DG eds. Principles and Practice of Pediatric OncologyJB Lippincott CompanyPhiladelphia, PA739768Google Scholar
- 19.Rothman, KJ, Greeland, S 1998Modern Epidemiology2Lippincott Williams & WilkinsPhiladelphia, PA126127Google Scholar