Cancer Causes & Control

, Volume 17, Issue 4, pp 469–480 | Cite as

Consumption of Alcoholic Beverages and Risk of Lung Cancer: Results from Two Case–control Studies in Montreal, Canada

  • Andrea BenedettiEmail author
  • Marie-Elise Parent
  • Jack Siemiatycki
Original Paper



To investigate the association between consumption of alcoholic beverages and lung cancer risk.


Data were collected in two population-based case–control studies, conducted in Montreal (Study I – mid-1980s and Study II – mid-1990s). Study I included 699 cases and 507 controls, all males; Study II included 1094 cases and 1468 controls, males and females. In each study group (Study I men, Study II men and Study II women) odds ratios (OR) were estimated for the associations between beer, wine or spirits consumption and lung cancer, while carefully adjusting for smoking and other covariates. The reference category included abstainers and occasional drinkers.


For Study I men, lung cancer risk increased with the average number of beers/week consumed (for 1–6 beers/week: OR=1.2, 95% confidence interval (CI): 0.9–1.7; for ≥7 beers/week: OR=1.5, 95% CI: 1.1–2.1). For Study II men, beer consumption appeared harmful only among subjects with low fruit and vegetable consumption. In Study II, wine consumers had low lung cancer risk, particularly those reporting 1–6 glasses/week (women: OR=0.3, 95% CI: 0.2–0.4; men: OR=0.6, 95% CI: 0.4–0.8).


Beer consumption increased lung cancer risk, particularly so among men who had relatively low fruit and vegetable consumption. Moderate wine drinkers had decreased lung cancer risk.


Alcohol drinking Lung neoplasms Case–control studies 



The fieldwork was supervised by Lesley Richardson. This study was supported by research and personnel support grants from Health Canada, the National Cancer Institute of Canada, the Institut de recherche en santé et sécurité au travail du Québec, the Fonds de la recherche en santé du Québec and the Canadian Institutes of Health Research.


  1. 1.
    Korte JE, Brennan P, Henley SJ, Boffetta P (2002) Dose-specific meta-analysis and sensitivity analysis of the relation between alcohol consumption and lung cancer risk. Am J Epidemiol 155:496–506CrossRefPubMedGoogle Scholar
  2. 2.
    Freudenheim JL, Ritz J, Smith-Warner SA, et al. (2005) Alcohol consumption and risk of lung cancer: a pooled analysis of cohort studies. Am J Clin Nutr 82:657–667PubMedGoogle Scholar
  3. 3.
    Bandera EV, Freudenheim JL, Vena JE (2001) Alcohol consumption and lung cancer: a review of the epidemiologic evidence. Cancer Epidemiol Biomarkers Prev 10:813–821PubMedGoogle Scholar
  4. 4.
    Parkin DM, Shanmugaratnam K, Sobin L, Ferlay J, Whelan SL (1998) Histological groups for comparative studies. IARC Technical Report No. 31. IARC, LyonGoogle Scholar
  5. 5.
    Gerin M, Siemiatycki J, Kemper H, Begin D (1985) Obtaining occupational exposure histories in epidemiologic case–control studies. J Occup Med 27:420–426PubMedGoogle Scholar
  6. 6.
    Siemiatycki J, Wacholder S, Richardson L, Dewar R, Gerin M (1987) Discovering carcinogens in the occupational environment. Methods of data collection and analysis of a large case-referent monitoring system. Scand J Work Environ Health 13:486–492PubMedGoogle Scholar
  7. 7.
    Leffondre K, Abrahamowicz M, Siemiatycki J, Rachet B (2002) Modeling smoking history: a comparison of different approaches. Am J Epidemiol 156:813–823CrossRefPubMedGoogle Scholar
  8. 8.
    Breslow N, Day N (1980) Statistical methods in cancer research. Volume 1: the analysis of case–control studies. International Agency for Research on Cancer, LyonGoogle Scholar
  9. 9.
    Benedetti A, Abrahamowicz M (2004) Using generalized additive models to reduce residual confounding. Stat Med 23:3781CrossRefPubMedGoogle Scholar
  10. 10.
    Hastie T, Tibshirani R (1990) Generalized additive models, Chapman and Hall, LondonGoogle Scholar
  11. 11.
    Parkin DM, Shanmugaratnam K, Sobin L, Ferlay J, Whelan SL (1998) Histological groups for comparative studies. IARC Technical Report No. 31. IARC, LyonGoogle Scholar
  12. 12.
    Gilpin E, Pierce J, Cavin S, et al. (1994) Estimates of population smoking prevalence: self vs. proxy reports of smoking status. Am J Public Health 84:1576PubMedGoogle Scholar
  13. 13.
    Patrick D, Cheadle A, Thompson D, Diehr P, Koepsell T, Kinne S (1994) The validity of self-reported smoking: a review and meta-analysis. Am J Public Health 84:1093Google Scholar
  14. 14.
    Nelson L, Lonstreth WJ, Koepsell T, Checkoway H, van Belle G (1994) Completeness and accuracy of interview data from proxy respondents: demographic, medical, and life-style factors. Epidemiology 5:204PubMedGoogle Scholar
  15. 15.
    Alberg AJ, Samet JM (2003) Epidemiology of Lung Cancer. Chest 123:21S–49CrossRefPubMedGoogle Scholar
  16. 16.
    Riboli E, Norat T (2003) Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. Am J Clin Nutr 78:559S–569PubMedGoogle Scholar
  17. 17.
    International Agency for Research on Cancer (2003) IARC Handbooks of cancer prevention: fruit and vegetables. IARC Press, LyonGoogle Scholar
  18. 18.
    Statistics Canada (2002) Canada Food Stats.Food Statistics. 2Google Scholar
  19. 19.
    De Stefani E, Correa P, Fierro L, Fontham ET, Chen V, Zavala D (1993) The effect of alcohol on the risk of lung cancer in Uruguay. Cancer Epidemiol Biomarkers Prev. 2:21–26PubMedGoogle Scholar
  20. 20.
    Kvale G, Bjelke E, Gart J (1983) Dietary habits and lung cancer risk. International Journal of Cancer 31:397Google Scholar
  21. 21.
    Bandera EV, Freudenheim JL, Graham S, et al. (1992) Alcohol consumption and lung cancer in white males. Cancer Causes Control 3:361–369CrossRefPubMedGoogle Scholar
  22. 22.
    Potter JD, McMichael AJ (1984) Alcohol, beer and lung cancer – a meaningful relationship? Int J Epidemiol 13:240–242PubMedGoogle Scholar
  23. 23.
    Hines LM, Rimm EB (2001) Moderate alcohol consumption and coronary heart disease: a review. Postgrad Med J 77:747–752CrossRefPubMedGoogle Scholar
  24. 24.
    Meister KA, Whelan EM, Kava R (2000) The health effects of moderate alcohol intake in humans: an epidemiologic review. Crit Rev Clin Lab Sci 37:261–296PubMedGoogle Scholar
  25. 25.
    Kabat GC, Wynder EL (1984) Lung cancer in nonsmokers. Cancer. 53:1214–1221PubMedGoogle Scholar
  26. 26.
    Bandera EV, Freudenheim JL, Marshall JR, et al. (1997) Diet and alcohol consumption and lung cancer risk in the New York State Cohort (United States). Cancer Causes Control 8:828–40CrossRefPubMedGoogle Scholar
  27. 27.
    Prescott E, Gronbaek M, Becker U, Sorensen TI (1999) Alcohol intake and the risk of lung cancer: influence of type of alcoholic beverage. Am J Epidemiol 149:463–470PubMedGoogle Scholar
  28. 28.
    Gordon T, Kannel WB (1984) Drinking and mortality. The Framingham Study. Am J Epidemiol 120:97–107PubMedGoogle Scholar
  29. 29.
    Potter JD, Sellers TA, Folsom AR, McGovern PG (1992) Alcohol, beer, and lung cancer in postmenopausal women. The Iowa Women’s Health Study. Ann Epidemiol 2:587–595PubMedGoogle Scholar
  30. 30.
    Koo LC (1988) Dietary habits and lung cancer risk among Chinese females in Hong Kong who never smoked. Nutr Cancer 11:155–172PubMedGoogle Scholar
  31. 31.
    Kubik AK, Zatloukal P, Tomasek L, et al. (2004) Dietary habits and lung cancer risk among non-smoking women. Eur J Cancer Prev. 13:471–480PubMedGoogle Scholar
  32. 32.
    Kubik A, Zatloukal P, Tomasek L, Pauk N, Petruzelka L, Plesko I (2004) Lung cancer risk among nonsmoking women in relation to diet and physical activity. Neoplasma. 51:136–143PubMedGoogle Scholar
  33. 33.
    Ruano-Ravina A, Figueiras A, Barros-Dios JM (2004) Type of wine and risk of lung cancer: a case–control study in Spain. Thorax 59:981–985CrossRefPubMedGoogle Scholar
  34. 34.
    De Stefani E, Correa P, Deneo-Pellegrini H, et al. (2002) Alcohol intake and risk of adenocarcinoma of the lung. A case–control study in Uruguay. Lung Cancer 38:9–14PubMedGoogle Scholar
  35. 35.
    Pollack ES, Nomura AM, Heilbrun LK, Stemmermann GN, Green SB (1984) Prospective study of alcohol consumption and cancer. N Engl J Med 310:617–621PubMedGoogle Scholar
  36. 36.
    Ellison RC ( 2002) Balancing the risks and benefits of moderate drinking. Ann N Y Acad Sci 957:1–6PubMedGoogle Scholar
  37. 37.
    Bianchini F, Vainio H (2003) Wine and resveratrol: mechanisms of cancer prevention? Eur J Cancer Prev 12:417–425PubMedGoogle Scholar
  38. 38.
    Bhat KPL, Pezzuto JM (2002) Cancer chemopreventive activity of reservatrol. Annal N Y Acad Sci 957:210–229Google Scholar
  39. 39.
    Naimi T, Brown D, Brewer R, et al. (2005) Cardiovascular risk factors and condounders among nondrinking and moderate drinking US adults. Am J Preventive Med 28:369–373Google Scholar
  40. 40.
    Del Boca FK, Darkes J (2003) The validity of self-reports of alcohol consumption: state of the science and challenges for research. [Review] [95 refs].Addiction 98:1CrossRefPubMedGoogle Scholar
  41. 41.
    Chaikelson JS, Arbuckle TY, Lapidus S, Gold DP (1994) Measurement of lifetime alcohol consumption. J Studies Alcohol 55:133–140Google Scholar
  42. 42.
    Del Boca FK, Noll JA (2000) Truth or consequences: the validity of self-report data in health services research on addictions. [Review] [42 refs]. Addiction 95:347CrossRefGoogle Scholar
  43. 43.
    Polich JM (1982) The validity of self-reports in alcoholism research. Addict Behav 7:123–132CrossRefPubMedGoogle Scholar
  44. 44.
    Boyle CA, Brann EA (1992) Proxy respondents and the validity of occupational and other exposure data. The Selected Cancers Cooperative Study Group. Am J Epidemiol 136:712–721PubMedGoogle Scholar
  45. 45.
    Graham P, Jackson R (1993) Primary versus proxy respondents: comparability of questionnaire data on alcohol consumption. Am J Epidemiol 138:443–452PubMedGoogle Scholar
  46. 46.
    Passaro KT, Noss J, Savitz DA, Little RE (1997) Agreement between self and partner reports of paternal drinking and smoking. The ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. Int J Epidemiol 26:315–320CrossRefPubMedGoogle Scholar
  47. 47.
    Nadalin V, Cotterchio M, McKeown-Eyssen G, Gallinger S (2003) Agreement between proxy- and case-reported information obtained using the self-administered Ontario Familial Colon Cancer Registry epidemiologic questionnaire. Chronic Dis Can 24:1–8PubMedGoogle Scholar

Copyright information

© Springer 2006

Authors and Affiliations

  • Andrea Benedetti
    • 1
    • 3
    Email author
  • Marie-Elise Parent
    • 1
  • Jack Siemiatycki
    • 2
  1. 1.Epidemiology and Biostatistics UnitINRS-Institut Armand-Frappier, Université du QuébecMontrealCanada
  2. 2.Département de médecine sociale et préventiveUniversité de MontréalMontrealCanada
  3. 3.CRCHUM – Santé des populationsMontrealCanada

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