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Cancer Causes & Control

, Volume 17, Issue 2, pp 199–208 | Cite as

Diet After Diagnosis and the Risk of Prostate Cancer Progression, Recurrence, and Death (United States)

  • June M. ChanEmail author
  • Crystal N. Holick
  • Michael F. Leitzmann
  • Eric B. Rimm
  • Walter C. Willett
  • Meir J. Stampfer
  • Edward L. Giovannucci
Original Paper

Abstract

Objectives We examined post-diagnostic diet and risk of cancer progression in a cohort of men with prostate cancer from the Health Professionals Follow-up Study.

Methods We observed 392 progression outcomes among 1,202 men diagnosed with incident localized/regional prostate cancer between 1986 and 1996. Men completed prospective dietary surveys before and after diagnosis and were followed through 2000. We examined post-diagnostic consumption of red meat, grains, vegetables, fruits, milk, tomatoes, tomato sauce, and fish as predictors of progression using Cox proportional hazard regression models adjusted for total energy, age, clinical factors, and pre-diagnostic diet.

Results Men in the highest versus lowest quartile of post-diagnostic fish consumption had a multivariate hazard ratio (HR) of progression of 0.73 (95% CI 0.52–1.02); the comparable HR for tomato sauce was 0.56 (95% CI 0.38–0.82). We observed inverse linear relationships for fish and tomato sauce and risk of progression (HR = 0.83, p-value = 0.006 and HR = 0.80, p-value = 0.04 for a two serving/week increase of fish and tomato sauce, respectively). Milk and fresh tomato consumption were associated with small elevations in risk.

Conclusions These data suggest that diet after diagnosis may influence the clinical course of prostate cancer, and fish and tomato sauce may offer some protection against disease progression.

Keywords

Diet Epidemiology Progression Prostate cancer Survivors 

Notes

Acknowledgements

We would like to thank the participants, without whom this research could not be done; and Mira Kaufman, Jason Salter, and Anne Que for their invaluable help in data management and project coordination.

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Copyright information

© Springer-Verlag 2006

Authors and Affiliations

  • June M. Chan
    • 1
    Email author
  • Crystal N. Holick
    • 2
  • Michael F. Leitzmann
    • 3
  • Eric B. Rimm
    • 2
    • 4
  • Walter C. Willett
    • 2
    • 4
  • Meir J. Stampfer
    • 2
    • 4
  • Edward L. Giovannucci
    • 2
    • 4
  1. 1.Departments of Epidemiology & Biostatistics and UrologyUniversity of CaliforniaSan FranciscoUSA
  2. 2.Departments of Nutrition and EpidemiologyHarvard School of Public HealthBostonUSA
  3. 3.Nutritional Epidemiology Branch, Division of Cancer Epidemiology and GeneticsNational Cancer Institute, NIH, DHHSBethesdaUSA
  4. 4.Channing Laboratory, Department of MedicineBrigham and Women’ Hospital and Harvard Medical SchoolBostonUSA

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