Cancer Causes & Control

, Volume 16, Issue 10, pp 1215–1224 | Cite as

Personal and Occupational Exposure to Organic Solvents and Risk of Non-Hodgkin’s Lymphoma (NHL) in Women (United States)

  • Ikuko KatoEmail author
  • Karen L. Koenig
  • Hiroko Watanabe-Meserve
  • Mark S. Baptiste
  • Patricia P. Lillquist
  • Glauco Frizzera
  • Jerome S. Burke
  • Miriam Moseson
  • Roy E. Shore


Objectives: The authors assessed whether home and occupational exposure to organic solvents is associated with risk of NHL in women.

Methods: A population-based, incidence case-control study was conducted in upstate New York, involving 376 NHL cases and 463 population controls selected from the Medicare beneficiary files and State driver’s license records. Exposure information was obtained by telephone interview. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using an unconditional logistic regression model, adjusting for a number of risk factors for NHL.

Results: Overall, history of exposure to organic solvents was not associated with the risk of NHL. A statistically significant increase in risk associated with occupational exposure was observed only for the subjects whose first exposure occurred before 1970 (OR=1.87, 95% CI 1.03–3.40). When occupational and home exposures to paint thinners/turpentine were combined and analyzed together, the risk of NHL associated with any exposure, compared to no exposure at either job or home, was a statistically significantly increased (OR=1.46, 95% CI: 1.05–2.03). This observation was more pronounced for B-cell lymphoma and for low-grade lymphoma with ORs of 1.52 (95 CI: 1.08–2.14) and 2.20 (95% CI; 1.42–3.41), respectively.

Conclusions: The results of this case-control study do support of a major role of organic solvents in the development of NHL among women currently living in the US. However, relatively intensive exposure in past occupations and use of paint thinners/turpentine may deserve further investigation.

Key words

case–control study NHL organic solvents women 


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  1. 1.
    Whysner, J, Reddy, MV, Ross, PM, Mohan, M, Lax, EA 2004Genotoxicity of benzene and its metabolitesMutat Res56699130CrossRefPubMedGoogle Scholar
  2. 2.
    Yin, SN, Hayes, RB, Linet, MS,  et al. 1996An expanded cohort study of cancer among benzene-exposed workers in China. Benzene Study GroupEnviron Health Perspect10413391341PubMedGoogle Scholar
  3. 3.
    Hayes, RB, Yin, SN, Dosemeci, M,  et al. 1996Mortality among benzene-exposed workers in ChinaEnviron Health Perspect10413491352PubMedGoogle Scholar
  4. 4.
    IARC (1989) Some Organic Solvents, Resin Monomers and Related Compounds, Pigments and Occupational Exposures in Paint Manufacture and Painting. IARC Monogr Eval Carcinog Risks Humans Vol 47. Lyon, France: IARC.Google Scholar
  5. 5.
    Lynge, E, Anttila, A, Hemminki, K 1997Organic solvents and cancerCancer Causes Control8406419CrossRefPubMedGoogle Scholar
  6. 6.
    IARC (1995) Dry Cleaning, some Chlorinated Solvents and other Industrial Chemicals. IARC Monogr Eval Carcinog Risks Humans Vol 63. Lyon, France: IARC.Google Scholar
  7. 7.
    Clean AIR Counts (accessed 30 November 2004) Available: 20Guided%20FINAL.htm.Google Scholar
  8. 8.
    Adgate, JL, Church, TR, Ryan, AD,  et al. 2004Outdoor, indoor, and personal exposure to VOCs in childrenEnviron Health Perspect11213861392PubMedGoogle Scholar
  9. 9.
    Harris, NC, Jaffe, ES, Stein, H,  et al. 1994A Revised European-American Classification of lymphoid neoplasms: a proposal from the International Lymphoma Study GroupBlood8413611392PubMedGoogle Scholar
  10. 10.
    Weisenburger, DD 1992Pathological classification of non-Hodgkin’s lymphoma for epidemiologic studiesCancer Res5254565464Google Scholar
  11. 11.
    Herrinton, LJ 1998Epidemiology of the Revised European-American Lymphoma Classification SubtypesEpidemiol Rev20187203PubMedGoogle Scholar
  12. 12.
    Giltay, EJ, Fonk, JC, Blomberg, BM, Drexhage, HA, Schalkwijk, C, Gooren, LJ 2000In vivo effects of sex steroids on lymphocyte responsiveness and immunoglobulin levels in humansJ Clin Endocrinol Metab8516481657CrossRefPubMedGoogle Scholar
  13. 13.
    Garcia, AM 2003Pesticide exposure and women’s healthAm J Indust Med44584594CrossRefGoogle Scholar
  14. 14.
    Kato, I, Koenig, KL, Shore, RE,  et al. 2002Use of anti-inflammatory and non-narcotic analgesic drugs and risk of Non-Hodgkin’s lymphoma (NHL)Cancer Causes Control13965974CrossRefPubMedGoogle Scholar
  15. 15.
    Kato, I, Koenig, KL, Baptiste, MS,  et al. 2003History of antibiotic use and risk of non-Hodgkin’s lymphoma (NHL)Int J Cancer10799105CrossRefPubMedGoogle Scholar
  16. 16.
    Kato, I, Watanabe-Meserve, H, Koenig, KL,  et al. 2004Pesticide product use and risk of non-Hodgkin lymphoma in womenEnviron Health Perspect1212751281Google Scholar
  17. 17.
    Breslow NE, Day NE (1980) Statistical Methods in Cancer Research, Vol I: The Analysis of Case-Control Studies. IARC Scientific Publications, No 32. Lyon: IARC.Google Scholar
  18. 18.
    Rego, MAV 1998Non-Hodgkin’s lymphoma risk derived from exposure to organic solvents: a review of epidemiologic studiesCad Saude Public144166Google Scholar
  19. 19.
    Singh, KP, Yoon, HL, Ratner, S, Reiners, JJ,Jr 1996Modulation of the development of humoral immunity by topically applied acetone, ethanol, and 12-–O-tetradecanoylphorbol-–13-–acetateFundam Appl Toxicol33129139CrossRefPubMedGoogle Scholar
  20. 20.
    Geiselhart, LA, Christian, T, Minnear, F, Freed, BM 1997The cigarette tar component p-benzoquinone blocks T-lymphocyte activation by inhibiting interleukin-2 production, but not CD25, ICAM-1, or LFA-1 expressionToxicol Appl Pharmacol1433036CrossRefPubMedGoogle Scholar
  21. 21.
    Palermo-Neto, J, Santos, FA, Guerra, JL, Santos, GO, Pinheiro, SR 2001Glue solvent inhalation impairs host resistance to Mycobacterium bovis-induced infection in hamstersVet Hum Toxicol4315PubMedGoogle Scholar
  22. 22.
    Hsieh, GC, Sharma, RP, Parker, RD 1991Hypothalamic-pituitary-adrenocortical axis activity and immune function after oral exposure to benzene and tolueneImmunopharmacology212331CrossRefPubMedGoogle Scholar
  23. 23.
    Ireland, B, Collins, JJ, Buckley, CF, Riordan, SG 1997Cancer mortality among workers with benzene exposureEpidemiology8318320CrossRefPubMedGoogle Scholar
  24. 24.
    Huebner, WW, Chen, VW, Friedlander, BR,  et al. 2000Incidence of lymphohaematopoietic malignancies in a petrochemical industry cohort: 1983–94 follow upOccup Environ Med57605614CrossRefPubMedGoogle Scholar
  25. 25.
    Persson, B, Dahlander, AM, Fredriksson, M, Brage, HN, Ohlson, CG, Axelson, O 1989Malignant lymphomas and occupational exposuresBr J Ind Med46516520PubMedGoogle Scholar
  26. 26.
    Persson, B, Fredrikson, M 1999Some risk factors for non-Hodgkin’s lymphomaInt J Occup Med Environ Health12135142PubMedGoogle Scholar
  27. 27.
    Norell, S, Ahlbom, A, Olin, R,  et al. 1986Occupational factors and pancreatic cancerBr J Ind Med43775778PubMedGoogle Scholar
  28. 28.
    Everett, G, Blair, A, Cantor, K, Gibson, R, VanLier, S 1985Environmental chemical exposures as risk factors for leukemia and non-Hodgkin’s lymphoma (abstract)Am J Epidemiol122535536Google Scholar
  29. 29.
    Roos, AJ, Olshan, AF, Teschke, K,  et al. 2001Parental occupational exposures to chemicals and incidence of neuroblastoma in offspringAm J Epidemiol154106114CrossRefPubMedGoogle Scholar
  30. 30.
    Inoue, T, Takeuchi, Y, Hisanaga, N,  et al. 1983A nationwide survey on organic solvent components in various solvent products: Part 1. Homogeneous products such as thinners, degreasers and reagentsInd Health21175183PubMedGoogle Scholar
  31. 31.
    National Toxicology Program (1999) NTP toxicology and carcinogenesis studies on ethylbenzene (CAS NO. 100-–41-–4) in F344/N rats and B6C3F1 mice (inhalation studies). Natl Toxicol Program Tech Rep Ser 466: 1–231.Google Scholar
  32. 32.
    IARC (1989) Occupational Exposures in Petroleum Refining; Crude Oil and Major Petroleum Fuels. IARC Monogr Eval Carcinog Risks Humans. Vol. 45: Lyon, France: IARC.Google Scholar
  33. 33.
    Cartwright, RA, McKinney, PA, O’Brien, C,  et al. 1988Non-Hodgkin’s lymphoma: case control epidemiological study in YorkshireLeuk Res128188CrossRefPubMedGoogle Scholar
  34. 34.
    Hardell, L, Eriksson, M, Degerman, A 1994Exposure to phenoxyacetic acids, chlorophenols, or organic solvents in relation to histopathology, stage, and anatomical localization of non-Hodgkin’s lymphomaCancer Res5423862389PubMedGoogle Scholar
  35. 35.
    Tatham, L, Tolbert, P, Kjeldsberg, C 1997Occupational risk factors for subgroups of non-Hodgkin’s lymphomaEpidemiology8551558CrossRefPubMedGoogle Scholar
  36. 36.
    Rego, MA, Sousa, CS, Kato, M, Carvalho, AB, Loomis, D, Carvalho, FM 2002Non-Hodgkin’s lymphomas and organic solventsJ Occup Environ Med44874881PubMedGoogle Scholar
  37. 37.
    Blair, A, Linos, A, Stewart, PA,  et al. 1992Comments on occupational and environmental factors in the origin of non-Hodgkin’s lymphomaCancer Res5255015502Google Scholar
  38. 38.
    Nordstrom, M, Hardell, L, Linde, A, Schloss, L, Nasman, A 1999Elevated antibody levels to Epstein-Barr virus antigens in patients with hairy cell leukemia compared to controls in relation to exposure to pesticides, organic solvents, animals, and exhaustsOncol Res11539544PubMedGoogle Scholar
  39. 39.
    Brandt, L, Kristoffersson, U, Olsson, H, Mitelman, F 1989Relation between occupational exposure to organic solvents and chromosome aberrations in non-Hodgkin’s lymphomaEur J Haematol42298302PubMedGoogle Scholar
  40. 40.
    Parry, JM, Parry, EM, Bourner, R,  et al. 1996The detection and evaluation of aneugenic chemicalsMutat Res3531146PubMedGoogle Scholar
  41. 41.
    Johansson, B, Mertens, F, Mitelman, F 1995Cytogenic evolution patterns non-Hodgkin’s lymphomaBlood8639053914PubMedGoogle Scholar
  42. 42.
    Infante-Rivard, C, Jacques, L 2000Empirical study of parental recall biasAm J Epidemiol 152480486CrossRefPubMedGoogle Scholar
  43. 43.
    Weinstock, MA, Colditz, GA, Willett, WC, Stampfer, MJ, Rosner, B, Speizer, FE 1991Recall (report) bias and reliability in the retrospective assessment of melanoma riskAm J Epidemiol133240245PubMedGoogle Scholar
  44. 44.
    Daniels, JL, Olshan, AF, Teschke, K, Hertz-Picciotto, I, Savitz, DA, Blatt, J 2001Comparison of assessment methods for pesticide exposure in a case-control interview studyAm J Epidemiol15312271232CrossRefPubMedGoogle Scholar
  45. 45.
    Meinert, R, Schuz, J, Kaletsch, U, Kaatsch, P, Michaelis, J 2000Leukemia and non-Hodgkin’s lymphoma in childhood and exposure to pesticides; results of a registry-based case-control study in GermanyAm J Epidemiol151639646PubMedGoogle Scholar
  46. 46.
    Fabbro-Peray, P, Daures, J-P, Rossi, J-F 2001Environmental risk factors for non-Hodgkin’s lymphoma: a population-based case-control study in Langueedoc-Roussillon, FranceCancer Causes Control12201212CrossRefPubMedGoogle Scholar

Copyright information

© Springer 2005

Authors and Affiliations

  • Ikuko Kato
    • 1
    • 2
    • 7
    Email author
  • Karen L. Koenig
    • 1
  • Hiroko Watanabe-Meserve
    • 1
  • Mark S. Baptiste
    • 3
  • Patricia P. Lillquist
    • 3
  • Glauco Frizzera
    • 4
    • 5
  • Jerome S. Burke
    • 6
  • Miriam Moseson
    • 1
  • Roy E. Shore
    • 1
  1. 1.Department of Environmental MedicineNew York University of School of MedicineNew YorkUSA
  2. 2.Karmanos Cancer Institute/Department of PathologyWayne State UniversityDetroitUSA
  3. 3.Bureau of Chronic Disease Epidemiology and SurveillanceNew York State Department of HealthAlbanyUSA
  4. 4.Department of PathologyNew York University Medical CenterNew YorkUSA
  5. 5.Department of PathologyWeill Medical College of Cornell UniversityNew YorkUSA
  6. 6.Department of PathologyAlta Bates Summit Medical CenterBerkeleyUSA
  7. 7.Karmanos Cancer InstituteDetroitUSA

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