Advertisement

Cancer Causes & Control

, Volume 16, Issue 6, pp 637–641 | Cite as

Obesity and the risk of prostate cancer (United States)

  • Brian D. Bradbury
  • Jemma B. Wilk
  • James A. KayeEmail author
Article

Abstract

The role of obesity in prostate cancer etiology remains controversial. A recent report suggested that obese men younger than age 60 may have a lower risk of developing prostate cancer than men the same age who are not obese. The current study used a nested, matched case–control study design and data collected in the General Practice Research Database between January 1991 and December 2001 to assess the association between body mass index (BMI) and the risk of incident prostate cancer. Seven hundred and thirty cases of prostate cancer with adequate information on BMI were identified and matched to 2740 controls on age, sex, general practice, and index date. Obese men (BMI ≥ 30.0 kilograms [kg]/square of height in meters [m2]) were at lower risk of developing prostate cancer (AOR=0.78, 95% CI: 0.56, 1.09) compared to normal weight men (BMI=23.0–24.9 kg/m2), and the data best fit an inverse quadratic model for the relation between BMI and the risk of prostate cancer. This study provides modest support for a protective association between obesity and the risk of incident prostate cancer.

Keywords

body mass index matched case–control study prostatic neoplasms. 

Abbreviations

AOR

adjusted odds ratio

BMI

body mass index

GP

general practitioner

GPRD

General Practice Research Database

kg

kilogram

m2

meter squared

OR

odds ratio

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Nomura, AM 2001Body size and prostate cancerEpidemiol Rev23126131PubMedGoogle Scholar
  2. 2.
    Cerhan, JR, Tomer, JC, Lynch, CF,  et al. 1997Association of smoking, body mass, and physical activity with risk of prostate cancer in the Iowa 65+ Rural Health Study (United States)Cancer Causes Control8229238CrossRefPubMedGoogle Scholar
  3. 3.
    Gronberg, H, Damber, L, Damber, JE 1996Total food consumption and body mass index in relation to prostate cancer risk: a case–control study in Sweden with prospectively collected exposure dataJ Urol155969974CrossRefPubMedGoogle Scholar
  4. 4.
    Veierod, MB, Laake, P, Thelle, DS 1997Dietary fat intake and risk of prostate cancer: a prospective study of 25,708 Norwegian menInt J Cancer73634638CrossRefPubMedGoogle Scholar
  5. 5.
    Anderson, S-O, Wolk, A, Bergstrom, R,  et al. 1997Body size and prostate cancer: a 20-year follow-up study among 135,006 Swedish construction workersJ Natl Cancer Inst89385389CrossRefPubMedGoogle Scholar
  6. 6.
    Giovannucci, E, Rimm, EB, Liu, Y,  et al. 2003Body mass index and risk of prostate cancer in U.S. health professionalsJ Natl Cancer Inst9512401244PubMedGoogle Scholar
  7. 7.
    Kolonel, LN, Nomura, AMY, Cooney, RV 1999Dietary fat and prostate cancer: current statusJ Natl Cancer Inst91414428CrossRefPubMedGoogle Scholar
  8. 8.
    Gann, PH, Hennekens, CH, Ma, J, Longcope, C, Stampfer, MJ 1996Prospective study of sex hormone levels and risk of prostate cancerJ Natl Cancer Inst8811181126PubMedGoogle Scholar
  9. 9.
    Hsing, AW, Chua, S,Jr., Gao, Y-T,  et al. 2001Prostate cancer risk and serum levels of insulin and leptin: a population-based studyJ Natl Cancer Inst93783789CrossRefPubMedGoogle Scholar
  10. 10.
    Henderson, BE, Ross, RK, Pike, MC, Casagrande, JT 1982Endogenous hormones as a major factor in human cancerCancer Res4232323239PubMedGoogle Scholar
  11. 11.
    Kelly, KM, Oh, Y, Gargosky, SE,  et al. 1996Insulin-like growth factor-binding proteins (IGFBPs) and their regulatory dynamicsInt J Biochem Cell Biol28619637CrossRefPubMedGoogle Scholar
  12. 12.
    Field, AE, Colditz, GA, Willett, WC, Longcope, C, McKinlay, JB 1994The relation of smoking, age, relative weight, and dietary intake to serum adrenal steroids, sex hormones, and sex hormone-binding globulin in middle-aged menJ Clin Endocrinol Metab7913101316CrossRefPubMedGoogle Scholar
  13. 13.
    Jick, H 1995A Major Resource for Drug Safety StudiesCentre for Medicines ResearchUKGoogle Scholar
  14. 14.
    Garcia Rodriguez, LA, Perez Gutthann, S 1998Use of the UK general practice research database for pharmacoepidemiologyBr J Clin Pharmacol45419425CrossRefPubMedGoogle Scholar
  15. 15.
    Jick, H, Terris, BZ, Derby, LE, Jick, SS 1992Further validation of information recorded on a general practitioner based computerized data resource in the United KingdomPharmacoepidemio Drug Safety1347349Google Scholar
  16. 16.
    Jick, SS, Kaye, JA, Vasilakis-Scaramozza, C,  et al. 2003Validity of the General Practice Research DatabasePharmacotherapy23686689CrossRefPubMedGoogle Scholar
  17. 17.
    Greenland, S 1998Basic methods for sensitivity analysis and external adjustmentRothman, KJGreenland, S eds. Modern EpidemiologyLippincottPhiladelphia, PA343357Google Scholar

Copyright information

© Springer 2005

Authors and Affiliations

  • Brian D. Bradbury
    • 1
    • 2
  • Jemma B. Wilk
    • 3
  • James A. Kaye
    • 1
    • 2
    Email author
  1. 1.Boston Collaborative Drug Surveillance ProgramBoston University School of MedicineLexingtonUSA
  2. 2.Department of EpidemiologyBoston University School of Public HealthBostonUSA
  3. 3.Departments of Neurology and MedicineBoston University School of MedicineBostonUSA

Personalised recommendations