Advertisement

Cancer Causes & Control

, Volume 16, Issue 5, pp 587–592 | Cite as

Pediatric brain tumors in Non-Hispanics, Hispanics, African Americans and Asians: differences in survival after diagnosis

  • Jill S. Barnholtz-Sloan
  • Richard K. Severson
  • Bonita Stanton
  • Merlin Hamre
  • Andrew E. Sloan
Article

Abstract

Background

Racial differences in survival for children with brain tumors have not been well studied, particularly in Hispanics and Asians. The objective of this study was to assess racial differences in survival of children with brain tumors, focusing on Hispanics, African Americans and Asians compared to Non-Hispanics.

Methods

Subjects identified through the SEER Program were 2799 children, ≤19 years old at diagnosis, newly diagnosed between 1973 and 1996 with primary, malignant brain tumors. Chi-square tests were used to evaluate prognostic variables by race. Kaplan–Meier models and Cox proportional hazards models were used to assess racial differences in overall survival and in survival by histological type of tumor.

Results

The distribution histological type of tumor varied significantly by race. Overall survival was similar for Hispanics, African Americans, Asians compared to Non-Hispanics, although trends of increased risk of death for the minority groups were noted when stratifying by histological type of tumor.

Conclusions

Racial differences in survival could exist by histological type of tumor, but further work is necessary for a more complete understanding of these differences.

Keywords

pediatric brain tumor race survival Hispanic Asian astrocytoma 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Ries LAG, et al. (1999) Cancer Incidence and Survival among Children and Adolescents: United States SEER Program 1975–1995, NIH Pub. No. 99-4649. Bethesda, Maryland: National Cancer Institute, SEER ProgramGoogle Scholar
  2. 2.
    Bleyer A, et al. In the United States, pediatric brain tumors and other CNS tumors are now more common than childhood ALL and have a 3-fold greater national mortality rate than ALL. Proceedings of the American Society of Clinical Oncology (ASCO)Google Scholar
  3. 3.
    Pollack, IF 1999Pediatric brain tumorsSemin Surg Oncol167390PubMedGoogle Scholar
  4. 4.
    Sklar, CA 2002Childhood brain tumorsJ Pediatr Endocrinol Metab15669673PubMedGoogle Scholar
  5. 5.
    Davis, FG,  et al. 1998Survival rates in patients with primary malignant brain tumors stratified by patient age and tumor histological type: an analysis based on Surveillance, Epidemiology, and End Results (SEER) data, 1973–1991J Neurosurg88110PubMedGoogle Scholar
  6. 6.
    Barnholtz-Sloan, JS, Sloan, AE, Schwartz, AG 2003Relative survival rates and patterns of diagnosis analyzed by time period for individuals with primary malignant brain tumor, 1973–1997J Neurosurg99458466PubMedGoogle Scholar
  7. 7.
    Barnholtz-Sloan, JS, Sloan, AE, Schwartz, AG 2003Racial differences in survival after diagnosis with primary malignant brain tumorCancer98603609CrossRefPubMedGoogle Scholar
  8. 8.
    Chen, P,  et al. 2001Ethnicity delineates different genetic pathways in malignant gliomaCancer Res6139493954PubMedGoogle Scholar
  9. 9.
    SEER (2003) Surveillance, Epidemiology and End Results (SEER) Program - seer.cancer.govGoogle Scholar
  10. 10.
    Jemal, A,  et al. 2004Annual report to the nation on the status of cancer, 1975–2001, with a special feature regarding survivalCancer101327CrossRefPubMedGoogle Scholar
  11. 11.
    CBTRUS2004Statistical Report: Primary Brain Tumors in the United States, 1997–2001Central Brain Tumor Registry of the United StatesChicagoGoogle Scholar
  12. 12.
    Grovas, A,  et al. 1997The National Cancer Data Base report on patterns of childhood cancers in the United StatesCancer8023212332CrossRefPubMedGoogle Scholar
  13. 13.
    Mahaley, MS,Jr,  et al. 1990Analysis of patterns of care of brain tumor patients in the United States: a study of the Brain Tumor Section of the AANS and the CNS and the Commission on Cancer of the ACSClin Neurosurg36347352PubMedGoogle Scholar
  14. 14.
    Ries, LAG,  et al. 2003SEER Cancer Statistics Review, 1975–2000, http://seer.cancer.gov/csr/National Cancer InstituteBethesda, MDGoogle Scholar
  15. 15.
    Surawicz, TS,  et al. 1999Descriptive epidemiology of primary brain and CNS tumors: results from the Central Brain Tumor Registry of the United States, 1990–1994Neuro-oncol11425CrossRefPubMedGoogle Scholar
  16. 16.
    Duffner, PK,  et al. 1986Survival of children with brain tumors: SEER Program, 1973–1980Neurology36597601PubMedGoogle Scholar
  17. 17.
    USCB (2003) U.S. Census Bureau, Population Division: Annual Estimates of the Population by Race Alone or in Combination and Hispanic or Latino Origin for the United States and States.: Washington DCGoogle Scholar
  18. 18.
    USCB1998United States Census Bureau (USCB). Current opulation reports, Series P23-194. Population profile of the United States: 1997US Government Printing OfficeWashington DCGoogle Scholar
  19. 19.
    Fritz, A,  et al. 2000International Classification of Diseases for Oncology, 3rd ednWorld Health OrganizationGenevaGoogle Scholar
  20. 20.
    Kaplan, EL, Meier, P 1958Nonparametric estimation from incomplete observationsJ Am Stat Assoc53457481Google Scholar
  21. 21.
    Cox, DR 1972Regression models and life-tablesJ Roy Stat Soc B30248275Google Scholar
  22. 22.
    Klein, JP, Moeschberger, ML 1998Survival AnalysisSpringer VerlagNew YorkGoogle Scholar
  23. 23.
    SAS (2003) Statistical Analysis Software, Version 9.1, Cary, North CarolinaGoogle Scholar
  24. 24.
    S-Plus (2003) Version 6.1 Professional, Insightful, Corp., Seattle, WAGoogle Scholar
  25. 25.
    Rosenfeld, JV, Ashley, DM 2001Management of brain tumors in the pediatric patientKaye, AHLaws, ER eds. Brain Tumors, 2nd edn. An Encyclopedic ApproachChurchill LivingstoneLondon2021Google Scholar
  26. 26.
    Mahaley, MS,Jr,  et al. 1989National survey of patterns of care for brain-tumor patientsJ Neurosurg71826836PubMedGoogle Scholar
  27. 27.
    Bleyer, WA,  et al. 1997National cancer clinical trials: children have equal access; adolescents do notJ Adolesc Health21366373CrossRefPubMedGoogle Scholar
  28. 28.
    Bleyer, WA,  et al. 1997Equal participation of minority patients in U.S. national pediatric cancer clinical trialsJ Pediatr Hematol Oncol19423427CrossRefPubMedGoogle Scholar
  29. 29.
    Swallen, KC,  et al. 1997Predictors of misclassification of Hispanic ethnicity in a population-based cancer registryAnn Epidemiol7200206CrossRefPubMedGoogle Scholar
  30. 30.
    USCensus (1980) U.S. Department of Commerce, Bureau of the Census. 1980 Census of Population and Housing: Spanish Surname List Technical Documentation. Washington, DC: U.S. Bureau of the Census, Data User Services DivisionGoogle Scholar
  31. 31.
    Messite, J, Stellman, SD 1996Accuracy of death certificate completion: the need for formalized physician trainingJama275794796CrossRefPubMedGoogle Scholar

Copyright information

© Springer 2005

Authors and Affiliations

  • Jill S. Barnholtz-Sloan
    • 1
  • Richard K. Severson
    • 2
    • 3
  • Bonita Stanton
    • 4
  • Merlin Hamre
    • 4
  • Andrew E. Sloan
    • 1
  1. 1.H. Lee Moffitt Cancer Center and Research InstituteMRC CANCONT TampaFlorida
  2. 2.Population Studies and Prevention Program – Epidemiology SectionBarbara Ann Karmanos Cancer InstituteUSA
  3. 3.Department of Family MedicineWayne State University School of MedicineDetroitUSA
  4. 4.Department of PediatricsChildren’s Hospital of Michigan and Wayne State UniversityDetroitUSA

Personalised recommendations