Cancer Causes & Control

, Volume 16, Issue 5, pp 525–535 | Cite as

Adipose levels of dioxins and risk of breast cancer

  • Peggy Reynolds
  • Susan E. Hurley
  • Myrto Petreas
  • Debbie E. Goldberg
  • Daniel Smith
  • Debra Gilliss
  • M. Ellen. Mahoney
  • Stefanie S. Jeffrey
Article

Abstract

Objective: Our objective was to evaluate the breast cancer risk associated with body burden levels of polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs).

Methods: We conducted a hospital-based case-control study among 79 women diagnosed with invasive breast cancer and 52 controls diagnosed with benign breast conditions. We collected breast adipose tissue and analyzed it for all 17 2,3,7,8-substitituted PCDD/PCDFs. We used unconditional logistic regression to calculate age- and race-adjusted exposure-specific odds ratios (ORs) and 95% confidence intervals (CI) for each individual PCDD/PCDF congener as well as for the summary measures (I-TEQ, Adj-TEQ).

Results: Dioxin levels were consistent with reports from other small, contemporary studies of body burdens in the U.S. None of the odds ratios for any of the congeners or summary measures differed significantly from one. Especially for the PCDF congeners, point estimates tended to be below one. One notable exception was octachlorodibenzo-p-dioxin (OCDD), for which the odds ratio for the second and third tertiles appeared modestly elevated (OR = 1.22, 95% CI: 0.47:3.16 and OR = 1.62, 95% CI: 0.64:4.12, respectively), though the test for trend was not significant (p = 0.36).

Conclusion: Breast cancer risk was not associated with adipose levels of PCDD/PCDFs. More study is suggested among women of color who may have higher body burden levels of these compounds.

Keywords

breast neoplasms adipose tissue body burden dioxins case-control studies 

Abbreviations

1234678-HpCDD

1,2,3,4,6,7,8-Heptachlorodibenzo-p-dioxin

1234678-HpCDF

1,2,3,4,6,7,8-Heptachlorodibenzofuran

123478-HxCDF

1,2,3,4,7,8-Hexachlorodibenzofuran

123678-HxCDD

1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin

123678-HxCDF

1,2,3,6,7,8-Hexachlorodibenzofuran

OCDD

1,2,3,4,6,7,8,9-Octachlorodibenzo-p-dioxin

12378-PeCDD

1,2,3,7,8-Pentachlorodibenzo-p-dioxin

23478-PeCDF

2,3,4,7,8-Pentachlorodibenzofuran

2378-TCDD

2,3,7,8-Tetrachlorodibenzo-p-dioxin

TCDD

Tetrachlorodibenzo-p-dioxin

Adj-TEQ

Adjusted Toxic Equivalents (congeners below detection are omitted)

β

beta

°C

degrees celsius

CI

confidence interval

CDTSC

California Department of Toxic Substances Control

DL

detection limit

HML

Hazardous Materials Laboratory

IARC

International Agency for Research on Cancer

I-TEQ

International Toxic Equivalents

m

meter

mm

millimeter

Na2SO4

sodium sulfate

OR

odds ratio

PBDEs

polybrominated diphenyl ethers

PCBs

polychlorinated biphenyls

PCDDs

polychlorinated dibenzo-p-dioxins

PCDFs

polychlorinated dibenzofurans

pg/g

picograms per gram – 10−12

SMR

standardized mortality ratio

SWHS

Seveso Women’s Health Study

TEQ

Toxic Equivalents

U.S.

United States

μ;L

microliter

μm

micrometer

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Copyright information

© Springer 2005

Authors and Affiliations

  • Peggy Reynolds
    • 1
  • Susan E. Hurley
    • 2
  • Myrto Petreas
    • 3
  • Debbie E. Goldberg
    • 2
  • Daniel Smith
    • 1
  • Debra Gilliss
    • 1
  • M. Ellen. Mahoney
    • 4
  • Stefanie S. Jeffrey
    • 4
  1. 1.California Department of Health ServicesEnvironmental Health Investigations BranchOaklandUSA
  2. 2.Public Health InstituteOaklandUSA
  3. 3.California Department of Toxic Substances ControlHazardous Materials LaboratoryBerkeleyUSA
  4. 4.Stanford University School of MedicineStanfordUSA

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