Cancer Causes & Control

, Volume 15, Issue 10, pp 1067–1076 | Cite as

Alcohol intake and risk of non-Hodgkin lymphoma in men and women

  • Ellen T. Chang
  • Karin Ekström Smedby
  • Shumin M. Zhang
  • Henrik Hjalgrim
  • Mads Melbye
  • Åke Öst
  • Alicja Wolk
  • Hans-Olov Adami
  • Bengt Glimelius
Article

Abstract

Objective: The effect of alcohol intake on risk of NHL is unclear. We therefore conducted a population-based case-control study to examine the association between alcohol and NHL risk.

Methods: 613 NHL cases and 480 population controls in Sweden reported their average consumption of beer, wine, and liquor 2 years before the study. Unconditional logistic regression was used to estimate the odds ratios (OR) and corresponding 95% confidence intervals (CI) for associations between alcohol intake and NHL risk.

Results: Intake of total alcohol, beer, wine, or liquor was not associated with risk of overall NHL. There was no difference in risk of NHL among those who habitually consumed above 19.1 g of ethanol per day, compared to those who consumed on average 0–2.2 g of ethanol per day (OR = 1.2 (95% CI: 0.8, 1.7); p trend = 0.29). However, the association was significantly positive among males (OR = 1.8 (95% CI: 1.1, 2.9); p trend = 0.06). Total alcohol, beer, wine, or liquor intake was not associated with any major histopathologic subtype of NHL examined, apart from an association between high wine consumption and increased risk of chronic lymphocytic leukemia.

Conclusions: Alcohol does not appear to be a major etiologic factor for overall NHL, nor its common subtypes.

alcohol epidemiology non-Hodgkin lymphoma 

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Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Ellen T. Chang
    • 1
  • Karin Ekström Smedby
    • 1
  • Shumin M. Zhang
    • 2
  • Henrik Hjalgrim
    • 3
  • Mads Melbye
    • 3
  • Åke Öst
    • 4
  • Alicja Wolk
    • 5
  • Hans-Olov Adami
    • 1
  • Bengt Glimelius
    • 6
  1. 1.Department of Medical Epidemiology and BiostatisticsKarolinska InstitutetStockholmSweden
  2. 2.Division of Preventive Medicine, Department of Medicine, Department of EpidemiologyBrigham and Women's Hospital and Harvard Medical School, Harvard School of Public HealthBostonUSA
  3. 3.Department of Epidemiology ResearchnStatens Serum InstitutCopenhagenDenmark
  4. 4.Department of Pathology and CytologyMedilabStockholmSweden
  5. 5.Division of Nutritional Epidemiology, The National Institute of Environmental MedicineKarolinska InstitutetStockholmSweden
  6. 6.Department of Oncology, Radiology and Clinical Immunology, Department of Oncology and PathologyUniversity of Uppsala, Karolinska Institutet, UppsalaStockholmSweden

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