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Cancer Causes & Control

, Volume 15, Issue 10, pp 1007–1019 | Cite as

A case–control study of occupational risk factors for bladder cancer in Canada

  • Reimar R. W. Gaertner
  • Ljiljana Trpeski
  • Kenneth C. Johnson
Article

Abstract

Objective: To investigate occupational risk factors for bladder cancer in seven Canadian provinces.

Methods: We analysed a population-based case–control dataset of 887 individuals with incident, histologically confirmed bladder cancer between 1994 and 1997. Controls (2847) frequency matched for age and gender were surveyed in 1996. Questionnaires were returned by about 60% of subjects. Odds ratios (ORs) for occupations and self-reported exposures were adjusted for province, age, race, smoking, and several dietary factors, using unconditional logistic regression.

Results: Statistically significant increased risks were observed among men employed as hairdressers (OR=3.42; 1.09–10.8), primary metal workers (OR = 2.40; 1.29–4.50), miners (OR = 1.94; 1.18–3.17), and automechanics (OR = 1.69; 1.02–2.82). Primary metal workers and automechanics showed evidence of an employment duration–response trend. Modest elevated risks that were not significant were also observed for male government inspectors, printers, firefighters, general labourers, and welders. A duration–response trend was evident for government inspectors and general labourers. For females, significant elevations were observed among lumber processors (OR = 8.78; 1.28–60.1), general labourers (OR = 2.18; 1.05–4.52), nurses (OR = 1.54; 1.03–2.31), and general clerks (OR = 1.48; 1.01–2.17). The latter showed a positive duration–response trend.

Conclusions: This study found a statistically significant excess risk of bladder cancer, with a duration–response trend, among male primary metal workers and automechanics, and female office workers engaged in general clerical duties.

bladder neoplasms case–control studies human occupational diseases 

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References

  1. 1.
    Pirastu R, Iavarone I, Comba P (1996) Bladder cancer:a selected review of the epidemiologic literature. Ann Ist Super Sanita 32: 3–20.Google Scholar
  2. 2.
    Silverman DT, Levin LI, Hoover RN, Hartge P (1989) Occupa-tional risks of bladder cancer in the United States:I. white men. J Natl Cancer Inst 81: 1472–1480.Google Scholar
  3. 3.
    Vineis P, Simonato L (1986) Estimation of the proportion of bladder cancer attributable to occupation. Scand J Work Environ Health 12: 55–60.Google Scholar
  4. 4.
    Schoenberg JB, Stemhagen A, Mogielnicki AP, et al. (1984) Case–control study of bladder cancer in New Jersey. I. occupational exposures in white males. J Natl Cancer Inst 72: 973–981.Google Scholar
  5. 5.
    Baxter PJ, McDowall ME (1986) Occupation and cancer in London:an investigation into nasal and bladder cancer using the cancer atlas. Br J Ind Med 43: 44–49.Google Scholar
  6. 6.
    Doll R, Peto R (1981) The Causes of Cancer:Quantitative Estimates of Avoidable Risks of Cancer in the United States Today. Oxford: Oxford University Press.Google Scholar
  7. 7.
    Moolgavkar SH, Stevens RG (1981) Smoking and cancer of bladder and pancreas:risks and temporal trends. J Natl Cancer Inst 67: 15–23.Google Scholar
  8. 8.
    Kogevinas M, Kauppinen T, Beffetta P, Saracci R (1998) Estimation of the Burden of Occupational Cancer in Europe. Final Report to the European Commission of a project funded by the programme 'Europe Against Cancer' (Contract SOC 96–200742 05F02). Barcelona, Institut Municipal d' Investigacio Medica.Google Scholar
  9. 9.
    Silverman DT, Morrison AS, Devesa SS (1996) Bladder cancer. In: Schottenfeld D, Fraumeni JF, eds. Cancer Epidemiology and Prevention. NewYork, NY: Oxford University Press, pp. 1156–1179.Google Scholar
  10. 10.
    Kogevinas M, Trichopoulos D (2002) Urinary bladder cancer. In: Adami HO, Hunter D, Trichopoulos D. eds. Textbook of Cancer Epidemiology. Oxford University Press, p. 454.Google Scholar
  11. 11.
    Johansson SL, Cohen SM (1997) Epidemiology and etiology of bladder cancer. Semin Surg Oncol 13: 291–298.Google Scholar
  12. 12.
    La Vecchia C, Airoldi L (1999) Human bladder cancer:epidemi-ological, pathological and mechanistic aspects. In:Capen CC, Dybing E, Rice JM and Wilbourn JD. eds. Species Differences in Thyroid, Kidney and Urinary Bladder Carcinogenesis. IARC Scientific Publications No. 147, pp. 139–157.Google Scholar
  13. 13.
    Steinmaus CM, Nunez S, Smith AH (2000) Diet and bladder cancer:a meta-anaylsis of six dietary variables. Am J Epidemiol 151: 693–702.Google Scholar
  14. 14.
    Cohen SM, Shirai T, Steineck G (2000) Epidemiology and etiology of premalignant and malignant urothelial changes. Scand J Urol Nephrol Suppl 205: 105–115.Google Scholar
  15. 15.
    Sala M, Cordier S, Chang-Claude J, et al. (2000) Coffee consump-tion and bladder cancer in nonsmokers:a pooled analysis of case–control studies in European countries. Cancer Causes Control 11: 925–931.Google Scholar
  16. 16.
    Zeegers MPA, Tan FES, Goldbohm RA, van den Brandt PA (2001) Are coffee and tea consumption associated with urinary tract cancer risk?A systematic review and meta-analysis. Int J Epidemiol 30: 353–362.Google Scholar
  17. 17.
    Johnson KC, Mao Y, Argo J, et al. (1998) The national enhanced cancer surveillance system:a case–control approach to environment-related cancer surveillance in Canada. Environmetrics 9: 495–504.Google Scholar
  18. 18.
    Parkes R, Kreiger N, James B, Johnson KC (2000) Effects On Response Rates Of Information Brochures And Small Cash Incentives In A Mail-Based Case–Control Study. Annals of Epidemiology 10: 117–124.Google Scholar
  19. 19.
    Standard Occupational Classification 1980 (1981) Statistics Canada, Ottawa.Google Scholar
  20. 20.
    Hosmer DW, Lemeshow S (2000) Applied Logistic Regression. 2nd edn. New York: John Wiley & Sons.Google Scholar
  21. 21.
    Coggon D, Pannett B, Osmond C, Acheson ED (1986) Use of a job-exposure matrix in an occupational analysis of lung and bladder cancers on the basis of death certificates. J Natl Cancer Inst 72: 61–65.Google Scholar
  22. 22.
    Risch HA, Burch JD, Miller AB, et al. (1988) Occupational factors and the incidence of cancer of the bladder in Canada. Br J Ind Med 45: 361–367.Google Scholar
  23. 23.
    Gonzalez CA, Lopez-Abente G, Errezola M, et al. (1989) Occu-pation and bladder cancer in Spain:a multi-centre case–control study. Int J Epidemiol 18: 569–577.Google Scholar
  24. 24.
    Anton-Culver H, Lee-Feldstein A, Taylor TH (1992) Occupation and bladder cancer risk. Am J Epidemiol 136: 89–94.Google Scholar
  25. 25.
    Sorahan T, Hamilton L, Wallace DMA, et al. (1998) Occupational urothelial tumours:a regional case–control study. Brit J Urol 82: 25–32.Google Scholar
  26. 26.
    Momas I, Daures JP, Festy B, Bontoux J, Gremy F (1994) Bladder cancer and black tobacco cigarette smoking. Eur J Epidemiol 10: 599–604.Google Scholar
  27. 27.
    Brennan P, Bogillot O, Cordier S, Greiser E, et al. (2000) Int J Cancer 86: 103–110.Google Scholar
  28. 28.
    Heinrich J, Mielck A, Schafer I, Mey W (2000) Social inequality and environmentally-related diseases in Germany:review of empirical results. Soz Praventivmed 45: 106–118.Google Scholar
  29. 29.
    Faggiano F, Partanen T, Kogevinas M, Boffetta P (1997) socioeconomic differences in cancer incidence and mortality. In: Kogevinas M, Pearce N, Susser M, Bofetta P, eds. Social Inequalities in Cancer. Lyon: IARC Scientific Publications No. 138, pp. 65–176.Google Scholar
  30. 30.
    Steinmaus CM, Nunez S, Smith AH (2000) Diet and bladder cancer:a meta-analysis of six dietary variables. Am J Epidemiol 151: 693–702.Google Scholar
  31. 31.
    Riboli E, Norat T (2003) Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. Am J Clin Nutr 78 (3 Suppl): 559S–569S.Google Scholar
  32. 32.
    Sala M, Cordier S, Chang-Claude J, Donato F, et al. (2000) Coffee consumption and bladder cancer in non-smokers:a pooled analysis of case–control studies in European countries. Cancer Causes Control 11: 925–931.Google Scholar
  33. 33.
    Zeegers MPA, Tan FES, Goldbohm RA, van den Brandt PA (2001) Are coffee and tea consumption associated with urinary tract cancer risk?A systematic review and meta-analysis. Int J Epidemiol 30: 353–362.Google Scholar
  34. 34.
    Tavani A, La Vecchia C (2000) Coffee and cancer: a review of epidemiological studies, 1990–1999. Eur J Cancer Prev 9: 241–256.Google Scholar
  35. 35.
    IARC (International Agency for Research on Cancer). Occupa-tional Exposures of Hairdressers and Barbers and Personal Use of Hair Colourants. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol 57. Lyon: IARC, 1993.Google Scholar
  36. 36.
    Kogevinas M, 't Mannetje A, Cordier S, Ranft U, Gonzalez CA, et al. (2003) Occupation and bladder cancer among men in Western Europe. Cancer Cause Control 14: 907–914.Google Scholar
  37. 37.
    't Mannetje A, Kogevinas M, Chang-Claude J, et al. (1999) Occupation and bladder cancer in European women. Cancer Causes Control 10: 209–217.Google Scholar
  38. 38.
    Andersen A, Barlow L, Engeland A, Kjaerheim K, Lynge E, Pukkala E (1999) Work-related cancer in the Nordic countries. Scand J Work Environ Health 25 (suppl 2):1–116.Google Scholar
  39. 39.
    Czene K, Tiikkaja S, Hemminki K (2003) Cancer risks in hairdressers:assessment of carcinogenicity of hair dyes and gels. Int J Cancer 105: 108–112.Google Scholar
  40. 40.
    Gaertner RRW, Theriault GP (2002) Risk of bladder cancer in foundry workers:a meta-analysis. Occup Environ Med 59: 655–663.Google Scholar
  41. 41.
    Pesch B, Haerting J, Ranft U, et al. (2000) Occupational risk factors for urothelial carcinoma:agent-specific results from a case–control study in Germany. Int J Epidemiol 29: 238–247.Google Scholar
  42. 42.
    Malker HSR, McLaughlin JK, Silverman DT, Ericsson JLE, et al. (1987) Occupational risks for bladder cancer among men in Sweden. Cancer Res 47: 6763–6766.Google Scholar
  43. 43.
    Cohen AJ, Higgins MW. Health effects of diesel exhaust: epidemiology. In:Diesel Exhaust:a Critical Analysis of Emissions, Exposure, and Health Effects. A special report of the Institute 's Diesel Working Group. Cambridge MA: Health Effects Institute. pp. 253–292.Google Scholar
  44. 44.
    Steenland K, Brown D (1995) Mortality study of gold miners exposed to silica and nonasbestiform amphibole minerals:an update with 14 more years of follow-up. Am J Ind Med 27: 217–229.Google Scholar
  45. 45.
    Muller J, Kusiak RA, Suranyi G, Ritchie AC. Study of Mortality of Ontario Gold Miners 1955–1977. Ontario Ministry of Labour, Ontario Workers' Compensation Board, Atomic Energy Control Board. 1986.Google Scholar
  46. 46.
    Porru S, Aulenti V, Donato F, et al. (1996) Bladder cancer and occupation:a case–control study in northern Italy. Occup Environ Med 53: 6–10.Google Scholar
  47. 47.
    Silverman DT, Levin LI, Hoover RN (1990) Occupational risks of bladder cancer among white women in the United States. Am J Epidemiol 132: 453–461.Google Scholar
  48. 48.
    Brown LM, Moradi T, Gridley G, Plate N, Dosemici M, Fraumeni JF (2002) Exposures in the painting trades and paint manufactur-ing industry and risk of cancer among men and women in Sweden. J Occup Environ Med 44: 258–264.Google Scholar
  49. 49.
    Steenland K, Palu S (1999) Cohort mortality study of 57, 000 painters and other union members:a 15-year update. Occup Environ Med 56: 315–321.Google Scholar
  50. 50.
    Terstegge CW, Swaen GM, Slangen JJ, et al. (1995) Mortality patterns among commercial painters in the Netherlands. J Occup Environ Med 1: 303–310.Google Scholar
  51. 51.
    Boffetta P, Silverman DT (2001) A meta-analysis of bladder cancer and diesel exhaust exposure. Epidemiology 12: 125–130.Google Scholar
  52. 52.
    Boffetta P, Jourenkova N, Gustavsson P (1997) Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons. Cancer Causes Control 8: 444–472.Google Scholar
  53. 53.
    Kogevinas M, Sala M, Boffetta P, Kazerouni N, Dromhout H, Hoar-Zahm S (1998) Cancer risk in the rubber industry:a review of the recent epidemiological evidence. Occup Environ Med 55: 1–12.Google Scholar
  54. 54.
    Demers PA, Checkoway H, Vaughan TL, et al. (1994) Cancer Incidence Among Firefighters in Seattle and Tacoma, Washington (United States). Cancer Causes Control 5: 129–135.Google Scholar
  55. 55.
    Baris D, Garrity TJ, Telles JL, et al. (2001) Cohort mortality study of Philadelphia firefighters. Am J Ind Med 39: 463–476.Google Scholar
  56. 56.
    Ma F, Lee DJ, Fleming LE, Dosemeci M (1998) Race-specific cancer mortality in US firefighters 1984–1993. J Occup Environ Med 40: 1134–1137.Google Scholar
  57. 57.
    Burns PB, Swanson GM (1991) Risk of urinary bladder cancer among blacks and whites:the role of cigarette use and occupation. Cancer Cause Control 2: 371–379.Google Scholar
  58. 58.
    Steenland K, Burnett C, Osorio AM (1987) A case–control study of bladder cancer using city directories as a source of occupational data. Am J Epidemiol 126: 247–257.Google Scholar
  59. 59.
    Teschke K, Morgan MS, Checkoway H, et al. (1997) Surveillance of nasal and bladder cancer to locate sources of exposure to occupational carcinogens. Occup Environ Med 54: 443–451.Google Scholar

Copyright information

© Kluwer Academic Publishers 2004

Authors and Affiliations

  • Reimar R. W. Gaertner
  • Ljiljana Trpeski
  • Kenneth C. Johnson

There are no affiliations available

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