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Breast Cancer Research and Treatment

, Volume 177, Issue 1, pp 233–233 | Cite as

ER(+)/HER2(+) and ER−/HER2(+) breast cancers might have different intracranial recurrence patterns after brain-directed radiation for brain metastases

  • Kadri AltundagEmail author
Letter to the Editor
  • 362 Downloads

Dear Editor,

I want to congratulate Cagney and their colleagues [1] in which they investigated intracranial recurrence patterns of brain metastases from breast cancer after brain-directed radiation to facilitate subtype-specific management paradigms. They reported a strong association between breast cancer subtype and intracranial recurrence patterns after brain-directed radiation, particularly local progression for HER2+ and distant progression for TNBC patients. However, the authors did not consider ER(+)/HER2(+) and ER-/HER2(+) as a different subtype. Analysis of HER2+ metastatic breast cancer has often been performed disregarding the ER status of the disease. Recent study examined the metastatic pattern and prognosis of both ER+/HER2+ and ER−/HER2+ 86,093 breast cancer patients [2]. This large study showed that patients with ER+/HER2+ and ER−/HER2+ breast cancers had different metastatic patterns and patients with ER−/HER2+ breast cancer had worse prognosis. Taken all together, ER(+)/HER2(+) and ER−/HER2(+) breast cancers might have different intracranial recurrence patterns after brain-directed radiation for brain metastases. This issue merits further investigation.

Notes

Funding

No funding for this paper. Author has not received any grants.

Compliance with ethical standards

Conflict of interest

I have no conflict of interest to declare.

Ethical approval

My manuscript complies with the Ethical Rules applicable for this journal.

Research involving human participants and/or animals

This article does not contain any studies with human participants or animals performed by any of the authors.

References

  1. 1.
    Cagney DN, Lamba N, Montoya S, Li P et al (2019) Breast cancer subtype and intracranial recurrence patterns after brain-directed radiation for brain metastases. Breast Cancer Res Treat.  https://doi.org/10.1007/s10549-019-05236-6 PubMedCrossRefGoogle Scholar
  2. 2.
    Arciero CA, Guo Y, Jiang R et al (2019) ER(+)/HER2(+) breast cancer has different metastatic patterns and better survival than ER-/HER2(+) breast cancer. Clin Breast Cancer 1:1–10.  https://doi.org/10.1016/j.clbc.2019.02.001 CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.MKA Breast Cancer ClinicAnkaraTurkey

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