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Breast Cancer Research and Treatment

, Volume 176, Issue 2, pp 419–427 | Cite as

Childbirth in young Korean women with previously treated breast cancer: The SMARTSHIP study

  • Hak Min Lee
  • Bo Wook Kim
  • Seho Park
  • Sungmin Park
  • Jeon Eon Lee
  • Young Jin Choi
  • Sung Yong Kim
  • Sang Uk Woo
  • Hyun Jo YounEmail author
  • Ilkyun LeeEmail author
Epidemiology

Abstract

Purpose

Alongside the modern trend of delaying childbirth, the high incidence of breast cancer among young women is causing significant pregnancy-related problems in Korea. We estimated the incidence of childbirth for young Korean breast cancer survivors compared with women who did not have breast cancer using a nationally representative dataset.

Methods

Using a database from the National Health Insurance Service in South Korea, we analyzed 109,680 women who were between 20 and 40 years old between 2007 and 2013. They were prospectively followed, and childbirth events were recorded until December 31, 2015. We compared childbirth rates and characteristics between the breast cancer survivors and the noncancer controls.

Results

Compared to 10,164 childbirths among 91,400 women without breast cancer (incidence rate: 22.3/1000), 855 childbirths occurred among 18,280 breast cancer survivors (incidence rate: 9.4/1000); the adjusted hazard ratio (HR) for childbirth was 0.41 (95% CI 0.38–0.44). Chemotherapy, endocrine therapy, and target therapy were associated with the decreasing childbirths among survivors, with corresponding adjusted HRs of 0.61 (0.53–0.70), 0.44 (0.38–0.51), and 0.62 (0.45–0.86), respectively. Breast cancer survivors had a lower probability of full-term delivery and a higher frequency of preterm labor than controls, with corresponding adjusted ORs of 0.78 (0.68–0.90) and 1.33 (1.06–1.65), respectively.

Conclusions

We showed that a history of breast cancer has a negative effect on childbirth among young premenopausal women in Korea. Breast cancer survivors should be aware that they have a higher risk for preterm labor and are less likely to have a full-term delivery than women without a history of breast cancer.

Keywords

Childbirth Incidence rate Breast cancer survivor 

Notes

Acknowledgements

This work was supported by the Korean Breast Cancer Society and the Study of Multi-disciplinARy Teamwork for breast cancer survivorSHIP (SMARTSHIP). This study enrolled patients from the National Health Information Database (NHIS-2017-4-011), which was provided and is maintained by the National Health Insurance Service (NHIS). The authors would like to thank the National Health Insurance Service for cooperation.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The authors declare that the present study complies with the current laws of Korea, and this study was approved by the Institutional Review Board of Catholic Kwandong University International St. Mary’s Hospital (IS16RCMI0053).

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Surgery, Catholic Kwandong University International St. Mary’s HospitalCatholic Kwandong University College of MedicineIncheonRepublic of Korea
  2. 2.Department of Obstetrics and Gynecology, Catholic Kwandong University International St. Mary’s HospitalCatholic Kwandong University College of MedicineIncheonRepublic of Korea
  3. 3.Division of Breast Surgery, Department of SurgeryYonsei University College of MedicineSeoulSouth Korea
  4. 4.Department of Surgery, Chungbuk National University HospitalChungbuk National University College of MedicineCheongjuSouth Korea
  5. 5.Department of SurgerySamsung Medical CenterSeoulSouth Korea
  6. 6.Department of Surgery, Soonchunhyang University Cheonan HospitalSoonchunhyang University College of MedicineCheonanSouth Korea
  7. 7.Department of SurgeryKorea University College of MedicineSeoulSouth Korea
  8. 8.Department of SurgeryChonbuk National University Medical SchoolJeonju-siRepublic of Korea

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