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Breast Cancer Research and Treatment

, Volume 176, Issue 1, pp 53–61 | Cite as

The relation between stressful life events and breast cancer: a systematic review and meta-analysis of cohort studies

  • Narjes Bahri
  • Tahereh Fathi Najafi
  • Fatemeh Homaei Shandiz
  • Hamid Reza TohidinikEmail author
  • Abdoljavad Khajavi
Review

Abstract

Purpose

Breast cancer is the most common cancer among women with high rate of mortality. This systematic review and meta-analysis was conducted to investigate the relation between stressful life events and breast cancer.

Methods

We searched PubMed, Scopus, ScienceDirect, and Google scholar databases from their inception until June 2018. The keywords and phrases we used in the search were (life events AND stress AND breast cancer OR neoplasm) to identify potentially relevant cohort studies that reported relative risk estimates and confidence intervals of this association. Pooled Risk ratio and 95% confidence intervals (CIs) were calculated using random effects model.

Results

Out of 168 potentially relevant publications, 11 documents met the inclusion criteria. The results showed that history of stressful life events slightly increases the risk of breast cancer [pooled Risk Ratio: 1.11 (95% CI 1.03 to 1.19)].

Conclusions

History of stressful life events could be associated with a moderate increase in the risk of breast cancer. We advise that receiving psychological and counseling services after occurrence of stressful life events of women should be taken seriously.

Keywords

Stress Life events Neoplasm Breast cancer Psychological distress 

Notes

Acknowledgements

We specially thank all researchers and scientists that have developed their research projects in breast cancer since the past decades and have provided us a treasure of valuable knowledge in this field.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Narjes Bahri
    • 1
  • Tahereh Fathi Najafi
    • 2
  • Fatemeh Homaei Shandiz
    • 3
  • Hamid Reza Tohidinik
    • 4
    • 5
    Email author
  • Abdoljavad Khajavi
    • 6
  1. 1.Department of Midwifery, Faculty of Medicine, Social Development and Health Promotion CenterGonabad University of Medical SciencesGonabadIran
  2. 2.Department of Midwifery, Mashhad BranchIslamic Azad UniversityMashhadIran
  3. 3.Department of Radiation Oncology, School of MedicineMashhad University of Medical SciencesMashhadIran
  4. 4.HIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in HealthKerman University of Medical SciencesKermanIran
  5. 5.Department of Epidemiology and Biostatistics, School of Public HealthTehran University of Medical SciencesTehranIran
  6. 6.Department of Social Medicine, School of MedicineGonabad University of Medical SciencesGonabadIran

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