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Breast Cancer Research and Treatment

, Volume 174, Issue 1, pp 165–177 | Cite as

Meta-analysis of upgrade rates in 3163 radial scars excised after needle core biopsy diagnosis

  • Gelareh FarshidEmail author
  • Elizabeth Buckley
Clinical trial
  • 116 Downloads

Abstract

Background

Since concurrent malignancy may be associated with radial scars (RS) in up to 45% of RS diagnosed on core biopsy, surgical excision is usually advised. Recent very low upgrade rates have caused a re-evaluation of the need for routine surgery. We aimed to find subsets of RS at such low risk of upgrade, as to render imaging surveillance a plausible alternative to surgery.

Design

We performed a systematic review of the Pubmed, Cochrane and Embase databases, focusing on the following eligibility criteria: full papers, published after 1998, in English, included at least 5 RS, provided information on needle biopsy gauge and upgrade rates based on the excised lesion. For the meta-analysis, studies were grouped by the presence of histologic atypia and the core needle gauge. Study-specific and pooled upgrade rates were calculated for each subgroup.

Results

49 studies that included 3163 RS with surgical outcomes are included. There were 217 upgrades to malignancies, 71 (32.7%) invasive and 144 (66.4%) DCIS. The random-effects pooled estimate was 7% (95% CI 5, 9%). Among the pre-planned subgroups, in RS assessed by 14G NCB the upgrade rates were: without atypia − 5% (95% CI 3, 8%), mixed or presence of atypia not specified − 15% (95% CI 10, 20%), with atypia − 29% (95% CI 20, 38%). For RS assessed by a mix of 8-16G cores the respective upgrade rates were 2% (95% CI 1, 4%), 12% (95% CI 6, 18%) and 11% (95% CI 3, 23%) and for RS assessed by 8–11 vacuum assisted biopsies 1% (95% CI 0, 4%), 5% (95% CI 0, 11%) and 18% for the one study of RS with atypia assessed by VAB. Surgery after VAB excision showed no upgrades. The difference across all subgroups was statistically significant.

Conclusion

When stratified by atypia and biopsy gauge, upgrade rates in RS are consistent and predictable. RS assessed by VABs and lacking atypia have a 1% (95% CI 0, 4%) upgrade rate to DCIS. Other groups have upgrade rates of 2–28%. This risk may be reduced by VAB excision. The results of this meta-analysis provide a decision aid and evidence-based selection criteria for surgery after a needle biopsy diagnosis of RS.

Keywords

Radial scar Breast cancer Screening Mammography Core biopsy 

Notes

Acknowledgements

We acknowledge the BreastScreen Australia Clinical Advisory Committee for supporting this work. We thank the editors and anonymous reviewers of the journal whose suggestions have improved the presentation of our work.

Compliance with ethical standards

Conflict of interest

Gelareh Farshid and Elizabeth Buckley declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Supplementary material

10549_2018_5040_MOESM1_ESM.docx (251 kb)
Supplementary material 1 (DOCX 251 KB)
10549_2018_5040_MOESM2_ESM.docx (26 kb)
Supplementary material 2 (DOCX 26 KB)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.South Australian PathologyRoyal Adelaide HospitalAdelaideAustralia
  2. 2.BreastScreen South AustraliaAdelaideAustralia
  3. 3.Discipline of MedicineAdelaide UniversityAdelaideAustralia
  4. 4.Cancer Epidemiology and Population Health Research GroupUniversity of South AustraliaAdelaideAustralia

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