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Which patients with sentinel node-positive breast cancer after breast conservation still receive completion axillary lymph node dissection in routine clinical practice?

  • André Hennigs
  • Melitta Köpke
  • Manuel Feißt
  • Fabian Riedel
  • Mahdi Rezai
  • Ulrike Nitz
  • Mareike Moderow
  • Michael Golatta
  • Christof Sohn
  • Andreas Schneeweiss
  • Jörg Heil
Epidemiology

Abstract

Purpose

In the American College of Surgeons Oncology Group (ACOSOG) Z0011 trial, patients with 1 or 2 tumour-involved sentinel lymph nodes (SLNs) gained no benefit from completion axillary lymph dissection (cALND). We examined implementation of evidence from this trial into routine clinical management.

Methods

Data were included from patients diagnosed with primary breast cancer in German breast cancer units between 2008 and 2015 and analysed retrospectively from a prospective maintained database. Descriptive analyses assessed time-trend changes in axillary surgery. Factors associated with cALND in patients with 1 or 2 positive SLNs were identified using multivariable logistic regression analysis.

Results

Overall, 179 breast cancer units provided data for 188,909 patients, of whom 13,741 (7.3%) had pT1/2cN0M0 invasive breast cancer with 1 or 2 tumour-involved SLNs and underwent breast-conserving surgery and adjuvant radiotherapy. cALND use decreased from 94.6% in 2008 to 46.9% in 2015 (p < 0.001). In multivariable analyses, the following factors were associated with cALND: fewer removed SLNs; two tumour-affected SLNs; younger age; lower annual case volume per hospital; higher tumour grade and lymphovascular invasion. No statistically significant influence was detected for hormone receptor or HER2 status.

Conclusion

In our cohort, 7.3% of patients with primary breast cancer met the ACOSOG Z0011 inclusion criteria and could potentially have been spared the morbidity of cALND. cALND tended to be performed in patients with a higher axillary tumour burden. This study shows a shift towards less extensive axillary surgery through rapid implementation of new clinical trial evidence into routine clinical practice.

Keywords

Breast cancer Axillary lymph node dissection Mastectomy ACOSOG Z0011 Time-tend analysis Sentinel lymph node dissection Tumour-involved sentinel lymph node 

Notes

Acknowledgements

The authors would like to thank all clinical research associates from the participating BCUs for documentation and data management, the WBC for providing the data and all the patients with breast cancer and their families. Editorial support was provided by Jennifer Kelly (Medi-Kelsey Ltd, Ashbourne, UK).

Funding

This research received funding from the German Cancer Aid (Grant No. 70112082). The funding source had no role in the study design, the collection, analysis and interpretation of the data, the writing of the report or the decision to submit the article for publication.

Compliance with ethical standards

Conflict of interest

There are no conflicts of interests (e.g. employment, consultancies, stock ownership, honoraria, paid expert testimony, patent applications/registrations or grants or other funding with regard to this study) for any of the authors.

Ethical approval

The study was approved by the ethics committee of the University of Heidelberg and was conducted in accordance with the Declaration of Helsinki. The study was deemed to be without risk, including only anonymised analysis of routinely collected data; consequently, the ethics committee of the University of Heidelberg did not request approval for consent for this designated analysis.

Informed consent

Informed consent was obtained from all individual participants within the data acquisition of the benchmarking process to analyse the anonymised data.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • André Hennigs
    • 1
  • Melitta Köpke
    • 1
  • Manuel Feißt
    • 2
  • Fabian Riedel
    • 1
  • Mahdi Rezai
    • 3
  • Ulrike Nitz
    • 4
  • Mareike Moderow
    • 5
  • Michael Golatta
    • 1
  • Christof Sohn
    • 1
  • Andreas Schneeweiss
    • 6
  • Jörg Heil
    • 1
  1. 1.Department of Gynecology and ObstetricsUniversity of HeidelbergHeidelbergGermany
  2. 2.Institute of Medical Biometry and InformaticsUniversity of HeidelbergHeidelbergGermany
  3. 3.European Breast CenterLuisen HospitalDüsseldorfGermany
  4. 4.Evangelical Hospital Johanniter Bethesda, Breast Center NiederrheinMönchengladbachGermany
  5. 5.West German Breast Center LtdDüsseldorfGermany
  6. 6.National Center for Tumor DiseasesUniversity of HeidelbergHeidelbergGermany

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