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Breast Cancer Research and Treatment

, Volume 174, Issue 1, pp 219–225 | Cite as

Sleep duration and risk of breast cancer: The JACC Study

  • Jinhong Cao
  • Ehab S. Eshak
  • Keyang Liu
  • Isao Muraki
  • Renzhe Cui
  • Hiroyasu IsoEmail author
  • Akiko Tamakoshi
  • JACC Study Group
Epidemiology

Abstract

Purpose

The evidence on beneficial or adverse effects of sleep duration on risk of breast cancer remains controversial and limited, especially in Asia.

Methods

A prospective study of 34,350 women aged 40–79 years in whom sleep duration, and menstrual and reproductive histories were determined by a self-administered questionnaire. The follow-up period was from 1988 to 2009, and hazard ratios (HRs) with 95% confidence intervals (CIs) of breast cancer incidence were calculated for shorter sleep duration in reference to sleep duration of ≥ 8 h/day by Cox proportional hazard models.

Results

During 19.2-year median follow-up (236 cases), we found a significant inverse association between sleep duration and risk of breast cancer, especially among postmenopausal women and women with low parity (nulliparous and women with < 3 children); the multivariable HRs (95% CIs) among postmenopausal women who reported 7 h/day and ≤ 6 h/day of sleep in reference to ≥ 8 h/day were 1.49 (0.81–2.76) and 1.98 (1.08–3.70) (P for trend = 0.028), respectively, and the corresponding values among women with low parity were 1.50 (0.96–2.35) and 1.76 (1.01–2.79) (P for trend = 0.018).

Conclusions

Short sleep duration was associated with increased risk of incident breast cancer, especially among postmenopausal women and women with low parity.

Keywords

Sleep duration Breast cancer Incidence Cohort study Postmenopausal Parity Japan 

Notes

Acknowledgements

The authors thank all staff members involved in this study for their valuable help in conducting the baseline survey and follow-up. Study investigators: Members of the JACC Study Group: Dr. Akiko Tamakoshi (present chairperson of the study group), Hokkaido University Graduate School of Medicine; Dr. Mitsuru Mori, Sapporo Medical University School of Medicine; Dr. Yoshihiro Kaneko, Akita University Graduate School of Medicine; Dr. Ichiro Tsuji, Tohoku University Graduate School of Medicine; Dr. Yosikazu Nakamura, Jichi Medical School; Dr. Hiroyasu Iso, Osaka University School of Medicine; Dr, Kazumasa Yamagishi, Faculty of Medicine, University of Tsukuba; Dr. Haruo Mikami, Chiba Cancer Center; Dr. Michiko Kurosawa, Juntendo University School of Medicine; Dr. Yoshiharu Hoshiyama, Yokohama Soei University; Dr. Naohito Tanabe, University of Niigata Prefecture; Dr. Koji Tamakoshi, Nagoya University Graduate School of Health Science; Dr. Kenji Wakai, Nagoya University Graduate School of Medicine; Dr. Shinkan Tokudome, National Institute of Health and Nutrition; Dr. Koji Suzuki, Fujita Health University School of Health Sciences; Drs. Shuji Hashimoto and Hiroshi Yatsuya, Fujita Health University School of Medicine; Dr. Shogo Kikuchi, Aichi Medical University School of Medicine; Dr. Yasuhiko Wada, Faculty of Nutrition, University of Kochi; Dr. Takashi Kawamura, Kyoto University Health Service; Dr. Yoshiyuki Watanabe, Kyoto Prefectural University of Medicine Graduate School of Medical Science; Dr. Kotaro Ozasa, Radiation Effects Research Foundation; Dr. Kazuya Mikami, Kyoto Prefectural University of Medicine Graduate School of Medical Science; Dr. Chigusa Date, School of Human Science and Environment, University of Hyogo; Dr. Kiyomi Sakata, Iwate Medical University; Dr. Yoichi Kurozawa, Tottori University Faculty of Medicine; Drs. Takesumi Yoshimura and Yoshihisa Fujino, University of Occupational and Environmental Health; Dr. Akira Shibata, Kurume University; Dr. Naoyuki Okamoto, Kanagawa Cancer Center; and Dr. Hideo Shio, Long-Term Care Health Facility Caretown Minamikusatsu, Shiga.

Funding

This work was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT) (Monbusho); Grants-in-Aid for Scientific Research on Priority Areas of Cancer; and Grants-in-Aid for Scientific Research on Priority Areas of Cancer Epidemiology from MEXT (MonbuKagaku-sho) (Nos. 61010076, 62010074, 63010074, 1010068, 2151065, 3151064, 4151063, 5151069, 6279102, 11181101, 17015022, 18014011, 20014026, 20390156, and 26293138); Comprehensive Research on Cardiovascular and Life-Style Related Diseases (H26-Junkankitou [Seisaku]-Ippan-001and H29-Junkankitou [Seishuu]-Ippan-003), JSPS KAKENHI Grant Number JP 16H06277, and Grants-in-Aid for China Scholarship Council (CSC file No. 201608050113).

Compliance with ethical standards

Conflict of interest

All authors declare that they have no conflicts of interest.

Ethical approval

All procedures performed in this study were in accordance with the Helsinki declaration and was approved by Osaka and Nagoya Universities research ethics committees.

Informed consent

Informed consent was obtained from all participants included in the study at individual or community leader level.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Public Health, Department of Social MedicineOsaka University Graduate School of MedicineOsakaJapan
  2. 2.Department of Public Health, Community and Preventive Medicine, Faculty of MedicineMinia UniversityMiniaEgypt
  3. 3.Department of Public Health, Faculty of MedicineHokkaido UniversitySapporoJapan

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