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Breast Cancer Research and Treatment

, Volume 172, Issue 2, pp 437–444 | Cite as

Differences in prognosis and efficacy of chemotherapy by p53 expression in triple-negative breast cancer

  • Soo Youn Bae
  • Seok Jin Nam
  • Yongsik Jung
  • Sae Byul Lee
  • Byung-Woo Park
  • Woosung Lim
  • Sung Hoo Jung
  • Hsien Wen Yang
  • Seung Pil Jung
Clinical trial
  • 230 Downloads

Abstract

Purpose

TP53 mutation is the most common mutation in breast cancer, and it is considered a target marker of triple-negative breast cancer (TNBC). We investigated whether expression of p53 detected by immunochemical staining predicts the chemotherapy response of TNBC.

Methods

A total of 11,393 TNBC patients who had between stage I and stage III enrolled in the Korean Breast Cancer Society Registry database from January 1, 2000 to December 31, 2015. There were 6,331 ‘p53-positive (+) TNBC’ patients and 5062 ‘p53-negative (−) TNBC’ patients.

Results

In univariate analysis, p53(+) TNBC had a worse prognosis than p53(−) TNBC in patients not receiving chemotherapy (P = 0.003). However, there was no difference in prognosis between p53(+) TNBC and p53(−) TNBC for patients receiving chemotherapy. In multivariate analysis adjusted for age and stage, the risk of p53(+) TNBC was 1.84 times higher than that of p53(−) TNBC in the non-chemotherapy group. However, there was no difference between p53(+) TNBC and p53(−) TNBC in patients receiving chemotherapy. In p53(+) TNBC, the risk was 0.6-fold lower when chemotherapy was administered than when chemotherapy was not administered. However, in p53(−) TNBC, there was no risk reduction effect by chemotherapy.

Conclusion

The prognosis of p53(+) TNBC has worse than p53(−) TNBC, but the risk for survival was significantly reduced with chemotherapy. It suggests that p53(+) TNBC would be more sensitive to chemotherapy than p53(−) TNBC.

Keywords

Triple-negative breast cancer Chemotherapy Prognosis P53 Immunohistochemistry 

Notes

Acknowledgements

This article was supported by the Korean Breast Cancer Society. This work was supported by the National Research Foundation of Korea (2017R1D1A1B03028103).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

For this type of study informed consent is not required.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Breast and Endocrine Surgery, Department of Surgery, Korea University Anam HospitalKorea University College of MedicineSeoulRepublic of Korea
  2. 2.Department of Surgery, Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea
  3. 3.Department of SurgeryAjou University School of MedicineGyeonggi-doRepublic of Korea
  4. 4.Department of Surgery, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea
  5. 5.Department of SurgeryYonsei University College of MedicineSeoulRepublic of Korea
  6. 6.Department of Surgery, Ewha Womans University Mokdong HospitalEwha Womans University College of MedicineSeoulRepublic of Korea
  7. 7.Department of Surgery, Chonbuk National University HospitalChonbuk National University Medical SchoolJeonjuRepublic of Korea

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