Screening status, tumour subtype, and breast cancer survival: a national population-based analysis
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We examined whether demographic and tumour characteristics (including subtype) were different for women with breast cancer diagnosed via mammography screening compared with women with interval breast cancers, lapsed attenders of the screening programme and non-participants of the screening programme. In addition, we explored whether there were survival differences between the groups, taking into account lead time bias.
We used linked data from National Cancer Registry Ireland and the national breast screening programme BreastCheck. Multinomial logistic regression was used to test the association of covariates with screening status. For survival analysis, we corrected the survival time for screen-detected cases for lead time bias, examined Kaplan–Meier curves and then used Cox regression to investigate differences in survival by screening status.
Subtype (HER2 over-expressing, triple negative), stage (III/IV), grade (poor), having co-morbidities, area of deprivation, smoking status and age were associated with having interval cancer or being a non-participant of the screening programme in the multivariable model. After correcting for lead time bias, and adjusting for variables associated with screening status, there was no evidence that risk of breast-cancer death for women with screen-detected cancer was different from women with interval cancer (HR = 0.76, 95% CI 0.56–1.03), non-participants (HR = 1.07, 95% CI 0.84–1.37) and lapsed attenders (HR = 0.97, 95% CI 0.65–1.45).
Screening status was strongly associated with subtype and this association persisted after adjustment for covariates including tumour stage and grade. After correcting for lead-time bias and adjusting for stage, subtype, grade and socio-demographic variables, no significant survival difference was demonstrated for women with screen-detected cancer in the 5-year period post-diagnosis. Since we are adjusting for stage, subtype and other variables, the lack of difference between these groups would be expected but has not been demonstrated in studies which do not correct for lead time bias.
KeywordsBreast cancer Screening Subtypes Survival Non-proportional hazards
We thank the tumour registration officers and other staff of the National Cancer Registry for their work in collecting and quality-assuring the data used in this analysis. We would like to thank Tracy Kelleher (NCRI) for matching the data.
The authors received no specific funding for this work.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflicts of interest.
The NCRI has permission under the Health (Provision of Information) Act 1997 to collect and hold data on all persons diagnosed with cancer in Ireland without requiring individual consent. The use of that data for research is covered by the Statutory Instrument which established the Registry Board in 1991. All datasets were anonymised prior to analysis.
At the time of screening, consent for data being shared with the National Cancer Registry was obtained by BreastCheck.
- 6.Gøtzsche PC, Jørgensen KJ (2013) Screening for breast cancer with mammography. Cochrane Database Syst Rev (6):CD001877Google Scholar
- 8.Rothman KJ (2012) Epidemiology: an introduction, 2nd edn. Oxford University Press, OxfordGoogle Scholar
- 17.Goldhirsch A, Wood WC, Coates AS, Gelber RD, Thürlimann B, Senn H-J (2011) Strategies for subtypes—dealing with the diversity of breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011. Ann Oncol 22(8):1736–1747CrossRefGoogle Scholar
- 19.Black R, Brewster D, Brown H, Fraser L, Harris V, Kidd J et al (2000) Trends in cancer survival in Scotland 1971–1995. ISD NHS in Scotland, Edinburgh (Scottish Cancer Intelligence Unit)Google Scholar
- 21.Small Area Health Research Unit (SAHRU) (1997) A National Deprivation Index for health and health services research. Technical Report No. 2. Dublin. http://hdl.handle.net/10147/264013