Breast Cancer Research and Treatment

, Volume 169, Issue 3, pp 639–640 | Cite as

Reply to Hollingsworth: does breast cancer metastasize in the clinical window between the mammogram and the mass?

  • Steven A. NarodEmail author
Rebuttal Letter
In our recent review, we proposed the parallel theory of breast cancer which, succinctly put, states that if a breast cancer is going to metastasize it will have done so before it is clinically apparent [ 1]. When I read Alan Hollingsworth’s excellent book Mammography and Early Breast Cancer Detection: How Screening Saves Lives [ 2] I realized that our hypothesis was a revisiting of early Fisher theory. Hollingsworth summarizes Fisher theory on page 17 of his book [ 2]:


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Conflict of interest

The author has no conflicts of interest to declare.


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Women’s College Hospital Research InstituteTorontoCanada

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