Reply to Hollingsworth: does breast cancer metastasize in the clinical window between the mammogram and the mass?
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In our recent review, we proposed the parallel theory of breast cancer which, succinctly put, states that if a breast cancer is going to metastasize it will have done so before it is clinically apparent [ 1]. When I read Alan Hollingsworth’s excellent book Mammography and Early Breast Cancer Detection: How Screening Saves Lives [ 2] I realized that our hypothesis was a revisiting of early Fisher theory. Hollingsworth summarizes Fisher theory on page 17 of his book [ 2]:
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