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Germline deleterious mutations in genes other than BRCA2 are infrequent in male breast cancer

  • Epidemiology
  • Published:
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Abstract

Purpose

Male breast cancer (MBC) is a rare cancer entity, with mutations in BRCA1 and BRCA2 genes accounting for ~ 10% of patients. Multiple-gene sequencing has already entered clinical practice for female breast cancer, whereas the performance of panel testing in MBC has not been studied extensively. Therefore, the aim of this study was to evaluate the clinical utility of panel testing for MBC, by the largest gene panel used so far, through investigation of patients deriving from a population with known founder effects.

Methods

Genomic DNA from one hundred and two Greek MBC patients, unselected for age and family history, was used to prepare libraries which capture the entire coding regions of 94 cancer genes.

Results

Loss-of-function (LoF) mutations were found in 12.7% of the cases, distributed in six genes: BRCA2, ATM, BRCA1, CHEK2, PMS2, and FANCL. BRCA2 mutations were the most frequent, followed by ATM mutations, accounting for 6.9 and 2%, respectively, while mutations in other genes were detected in single cases. Age at diagnosis or family history was not predictive of mutation status. Beyond mutations in established breast cancer predisposing genes, LoF mutations in PMS2 and FANCL among MBC patients are reported here for the first time.

Conclusions

Our findings, using the largest gene panel for MBC patients so far, indicate that BRCA testing should be the primary concern for MBC patients. Until sufficient evidence arises from larger studies, multiple-gene panels may be of limited benefit for MBC and their families, at least for MBC patients of specific descent.

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Acknowledgements

We are indebted to the patients who participated in our research.

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Authors and Affiliations

  1. Molecular Diagnostics Laboratory, INRaSTES, National Centre for Scientific Research ‘Demokritos’, Patriarchou Gregoriou E’ & Neapoleos Street, 15310, Athens, Greece

    Florentia Fostira, Paraskevi Apostolou, Andromahi Vagena, Despoina Kalfakakou, Drakoulis Yannoukakos & Irene Konstantopoulou

  2. Oncology Unit, General Hospital of Heraklion ‘Venizelio-Pananio’, Heraklion, Crete, Greece

    Emmanouil Saloustros

  3. General Hospital of Lamia, Lamia, Greece

    Davide Mauri

  4. Second Department of Medical Oncology, ‘Agios Savvas’ Anticancer Hospital, Athens, Greece

    Dimitrios Tryfonopoulos

  5. Department of Medical Oncology, University Hospital of Heraklion, Heraklion, Greece

    Vassileios Georgoulias

  6. Aristotle University of Thessaloniki School of Medicine, Thessaloniki, Greece

    Georgios Fountzilas

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  1. Florentia Fostira
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Fostira, F., Saloustros, E., Apostolou, P. et al. Germline deleterious mutations in genes other than BRCA2 are infrequent in male breast cancer. Breast Cancer Res Treat 169, 105–113 (2018). https://doi.org/10.1007/s10549-018-4661-x

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