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Breast Cancer Research and Treatment

, Volume 165, Issue 3, pp 751–756 | Cite as

Oncologists’ influence on receipt of adjuvant chemotherapy: does it matter whom you see for treatment of curable breast cancer?

  • Steven J. Katz
  • Sarah T. Hawley
  • Irina Bondarenko
  • Reshma Jagsi
  • Kevin C. Ward
  • Timothy P. Hofer
  • Allison W. Kurian
Epidemiology

Abstract

Purpose

We know little about whether it matters which oncologist a breast cancer patient sees with regard to receipt of chemotherapy. We examined oncologists’ influence on use of recurrence score (RS) testing and chemotherapy in the community.

Methods

We identified 7810 women with stages 0-II breast cancer treated in 2013-15 through the SEER registries of Georgia and Los Angeles County. Surveys were sent 2 months post-surgery, (70% response rate, n = 5080). Patients identified their oncologists (n = 504) of whom 304 responded to surveys (60%). We conducted multi-level analyses on patients with ER-positive HER2-negative invasive disease (N = 2973) to examine oncologists’ influence on variation in RS testing and chemotherapy receipt, using patient and oncologist survey responses merged to SEER data.

Results

Half of patients (52.8%) received RS testing and 27.7% chemotherapy. One-third (35.9%) of oncologists treated >50 new breast cancer patients annually; mean years in practice was 15.8. Oncologists explained 17% of the variation in RS testing but little of the variation in chemotherapy receipt (3%) controlling for clinical factors. Patients seeing an oncologist who was one standard deviation above the mean use of RS testing had over two-times higher odds of receiving RS (2.47, 95% CI 1.47–4.15), but a parallel estimate of the association of oncologist with the odds of receiving chemotherapy was much smaller (1.39, CI 1.03–1.88).

Conclusions

Clinical algorithms have markedly reduced variation in chemotherapy use across oncologists. Oncologists’ large influence on variation in RS use suggests that they variably seek tumor profiling to inform treatment decisions.

Keywords

Breast cancer Oncologist Chemotherapy Recurrence score assay 

Notes

Acknowledgements

Research reported in this publication was supported by the National Cancer Institute (NCI) of the National Institutes of Health under Award No. P01CA163233 to the University of Michigan. The collection of cancer incidence data used in this study was supported by the California Department of Public Health pursuant to California Health and Safety Code Section 103885; Centers for Disease Control and Prevention’s (CDC) National Program of Cancer Registries, under cooperative Agreement 5NU58DP003862-04/DP003862; the NCI’s Surveillance, Epidemiology and End Results Program under Contract HHSN261201000140C awarded to the Cancer Prevention Institute of California, Contract HHSN261201000035C awarded to the University of Southern California (USC), and Contract HHSN261201000034C awarded to the Public Health Institute. The collection of cancer incidence data in Georgia was supported by Contract HHSN261201300015I, Task Order HHSN26100006 from the NCI and cooperative Agreement 5NU58DP003875-04-00 from the CDC. The ideas and opinions expressed herein are those of the author(s) and endorsement by the State of California, Department of Public Health, the NCI, and the CDC or their Contractors and Subcontractors is not intended nor should be inferred. We acknowledge the work of our project staff (Mackenzie Crawford, M.P.H. and Kiyana Perrino, M.P.H. from the Georgia Cancer Registry; Jennifer Zelaya, Pamela Lee, Maria Gaeta, Virginia Parker, B.A. and Renee Bickerstaff-Magee from USC; Rebecca Morrison, M.P.H., Alexandra Jeanpierre, M.P.H., Stefanie Goodell, B.S., Paul Abrahamse, M.A., and Rose Juhasz, Ph.D. from the University of Michigan). We acknowledge with gratitude our survey respondents.

Compliance with ethical standards

Conflict of interest

The author(s) declare that they have no competing interests.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Participants were informed that the return of a completed survey indicated their consent.

Supplementary material

10549_2017_4377_MOESM1_ESM.tif (347 kb)
Supplemental Figure (TIFF 346 kb)

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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Steven J. Katz
    • 1
    • 2
  • Sarah T. Hawley
    • 1
    • 2
    • 3
  • Irina Bondarenko
    • 4
  • Reshma Jagsi
    • 5
  • Kevin C. Ward
    • 6
  • Timothy P. Hofer
    • 1
    • 3
  • Allison W. Kurian
    • 7
  1. 1.Department of Internal MedicineUniversity of MichiganAnn ArborUSA
  2. 2.Department of Health Management and PolicyUniversity of MichiganAnn ArborUSA
  3. 3.Ann Arbor Veterans Affairs Center for Clinical Management ResearchAnn ArborUSA
  4. 4.Department of BiostatisticsUniversity of MichiganAnn ArborUSA
  5. 5.Department of Radiation OncologyUniversity of MichiganAnn ArborUSA
  6. 6.Department of EpidemiologyEmory UniversityAtlantaUSA
  7. 7.Department of MedicineStanford UniversityStanfordUSA

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