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Breast Cancer Research and Treatment

, Volume 160, Issue 3, pp 523–530 | Cite as

Internal mammary node adenopathy on breast MRI and PET/CT for initial staging in patients with operable breast cancer: prevalence and associated factors

  • Hyejin Cheon
  • Hye Jung Kim
  • Sang-Woo Lee
  • Do-Hoon Kim
  • Chang-Hee Lee
  • Seung Hyun Cho
  • Kyung Min Shin
  • So Mi Lee
  • Gab Chul Kim
  • Won Hwa KimEmail author
Epidemiology

Abstract

Purpose

To evaluate the prevalence of and factors associated with internal mammary node (IMN) adenopathy on MRI and PET/CT used for initial staging in patients with operable breast cancer.

Methods

A total of 1320 patients diagnosed with invasive breast carcinoma between January 2011 and December 2015 underwent MRI and PET/CT for initial staging. The patients were considered to have IMN adenopathy when MRI revealed IMNs with the longest diameter of 5 mm or greater and a standardized uptake value greater than that of the mediastinal blood pool/contralateral parasternal area on PET/CT. The prevalence was determined as overall percentage of patients with IMN adenopathy, as well as percentages among patients who received neoadjuvant chemotherapy and those who did not. The association of IMN adenopathy with factors was evaluated using multivariate logistic regression analysis.

Results

Of the 1320 patients, 35 patients [2.7 %; 95 % confidence interval (CI) 1.8–3.6 %] had IMN adenopathy, with a total of 49 IMNs. Among patients without and with neoadjuvant chemotherapy (n = 1092 and n = 228, respectively), IMN adenopathy was identified in 13 (1.2 %; 95 % CI 0.6–2.0 %) and 22 patients (9.6 %; 95 % CI 6.0–14.6 %), respectively. Inner tumor location [odds ratio (OR) 5.9; P = .002] and positive axillary lymph node status (OR 4.4; P < .0001) were associated with IMN adenopathy.

Conclusions

IMN adenopathy was identified at initial staging with PET/CT and MRI with a prevalence of 2.7 %. Inner tumor location and positive axillary lymph node status were associated with IMN adenopathy.

Keywords

Invasive breast cancer Breast MRI PET–CT Internal mammary node IMN adenopathy 

Notes

Acknowledgments

This work was supported by Biomedical Research Institute Grant, Kyungpook National University Hospital (2016).

Compliance with ethical standards

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Hyejin Cheon
    • 1
  • Hye Jung Kim
    • 1
  • Sang-Woo Lee
    • 2
  • Do-Hoon Kim
    • 2
  • Chang-Hee Lee
    • 2
  • Seung Hyun Cho
    • 1
  • Kyung Min Shin
    • 1
  • So Mi Lee
    • 1
  • Gab Chul Kim
    • 1
  • Won Hwa Kim
    • 1
    Email author
  1. 1.Department of RadiologyKyungpook National University Medical CenterDaeguKorea
  2. 2.Department of Nuclear MedicineKyungpook National University Medical CenterDaeguKorea

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