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Breast Cancer Research and Treatment

, Volume 154, Issue 1, pp 117–125 | Cite as

Black breast cancer survivors experience greater upper extremity disability

  • Lorraine T. Dean
  • Angela DeMichele
  • Mously LeBlanc
  • Alisa Stephens-Shields
  • Susan Q. Li
  • Chris Colameco
  • Morgan Coursey
  • Jun J. Mao
Epidemiology

Abstract

Over one-third of breast cancer survivors experience upper extremity disability. Black women present with factors associated with greater upper extremity disability, including: increased body mass index (BMI), more advanced disease stage at diagnosis, and varying treatment type compared with Whites. No prior research has evaluated the relationship between race and upper extremity disability using validated tools and controlling for these factors. Data were drawn from a survey study among 610 women with stage I–III hormone receptor positive breast cancer. The disabilities of the arm, shoulder and hand (QuickDASH) is an 11-item self-administered questionnaire that has been validated for breast cancer survivors to assess global upper extremity function over the past 7 days. Linear regression and mediation analysis estimated the relationships between race, BMI and QuickDASH score, adjusting for demographics and treatment types. Black women (n = 98) had 7.3 points higher average QuickDASH scores than White (n = 512) women (p < 0.001). After adjusting for BMI, age, education, cancer treatment, months since diagnosis, and aromatase inhibitor status, Black women had an average 4-point (95 % confidence interval 0.18–8.01) higher QuickDASH score (p = 0.04) than White women. Mediation analysis suggested that BMI attenuated the association between race and disability by 40 %. Even several years post-treatment, Black breast cancer survivors had greater upper extremity disability, which was partially mediated by higher BMIs. Close monitoring of high BMI Black women may be an important step in reducing disparities in cancer survivorship. More research is needed on the relationship between race, BMI, and upper extremity disability.

Keywords

Breast cancer Upper extremity function Disability Black/African-American Philadelphia, Pa 

Abbreviations

AI

Aromatase inhibitor

BMI

Body mass index

QuickDASH

Disabilities of the arm, shoulder and hand

UED

Upper extremity disability

Notes

Acknowledgments

This study was supported by National Institutes of Health/National Cancer Institute 1R01CA158243. Dr. Dean is supported in part by the National Institutes of Health and National Cancer Institute Grant No. 1K01CA184288.

Compliance with ethical standards

Conflict of Interest

The authors declare that they have no conflict of interest.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Lorraine T. Dean
    • 1
  • Angela DeMichele
    • 1
    • 2
  • Mously LeBlanc
    • 2
    • 3
  • Alisa Stephens-Shields
    • 1
  • Susan Q. Li
    • 4
  • Chris Colameco
    • 2
  • Morgan Coursey
    • 1
  • Jun J. Mao
    • 1
    • 2
    • 4
  1. 1.School of Medicine, Center for Clinical Epidemiology and BiostatisticsUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Abramson Cancer CenterUniversity of PennsylvaniaPhiladelphiaUSA
  3. 3.Physical Medicine and RehabilitationUniversity of PennsylvaniaPhiladelphiaUSA
  4. 4.Family Medicine and Community Health at the Hospital of the University of PennsylvaniaUniversity of PennsylvaniaPhiladelphiaUSA

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