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Breast Cancer Research and Treatment

, Volume 151, Issue 1, pp 209–217 | Cite as

Family history and risk of pregnancy-associated breast cancer (PABC)

  • Anna L. V. JohanssonEmail author
  • Therese M.-L. Andersson
  • Chung-Cheng Hsieh
  • Sven Cnattingius
  • Paul W. Dickman
  • Mats Lambe
Epidemiology

Abstract

The risk of breast cancer is at least two-fold increased in young women with a family history of breast cancer. Pregnancy has a dual effect on breast cancer risk; a short-term increase followed by a long-term protection. We investigated if the risk of breast cancer during and within 10 years following pregnancy is affected by a family history of breast cancer. We followed a cohort of women aged 15–44 years between 1963 and 2009 identified in Swedish population-based registers. Family history was defined as having a mother or sister with breast cancer. We estimated incidence rate ratios of breast cancer during pregnancy and time intervals up to 10 years post-delivery, with a focus on pregnancy-associated breast cancer (PABC), defined as breast cancer during pregnancy or within 2 years post-delivery. In 3,452,506 women, there were 15,548 cases of breast cancer (1208 were PABC). Compared to nulliparous women, the risk of breast cancer was decreased during pregnancy, similar during first year and increased during second year post-delivery. The pattern was similar in women with or without family history of breast cancer. A peak in risk was observed 5–6 years following the first birth regardless of family history. After a second birth, this peak was only present in women with a family history. Our results indicate that women with a family history of breast cancer do not have a different breast cancer risk during and within 10 years following pregnancy compared to women without a family history.

Keywords

Pregnancy Family history Breast cancer Register-based cohort Sweden Case-cohort 

Notes

Acknowledgments

This work was supported by a grant from Susan G. Komen for the Cure (Grant number KG 100116).

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

The study was approved by the Ethical Review Board at Karolinska Institutet, Sweden. For this type of study formal consent is not required.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Anna L. V. Johansson
    • 1
    Email author
  • Therese M.-L. Andersson
    • 1
  • Chung-Cheng Hsieh
    • 2
  • Sven Cnattingius
    • 3
  • Paul W. Dickman
    • 1
  • Mats Lambe
    • 1
    • 4
  1. 1.Department of Medical Epidemiology and BiostatisticsKarolinska InstitutetStockholmSweden
  2. 2.Department of Molecular, Cell and Cancer BiologyUniversity of Massachusetts Medical SchoolWorcesterUSA
  3. 3.Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska University HospitalKarolinska InstitutetStockholmSweden
  4. 4.Regional Cancer CentreUppsalaSweden

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