Breast Cancer Research and Treatment

, Volume 150, Issue 3, pp 675–684 | Cite as

Personality and breast cancer risk and survival: the Miyagi Cohort Study

  • Yuko Minami
  • Toru Hosokawa
  • Naoki Nakaya
  • Yumi Sugawara
  • Yoshikazu Nishino
  • Yoichiro Kakugawa
  • Akira Fukao
  • Ichiro Tsuji
Epidemiology

Abstract

It has long been hypothesized that personality is associated with breast cancer risk and survival. The present population-based prospective cohort study in Japan tested this hypothesis. To investigate the association of personality with breast cancer risk, a total of 15,107 women aged 40–64 years who completed the Eysenck Personality Questionnaire-Revised (EPQ-R) Short Form were followed from 1990 to 2007. To assess the association of personality with survival after breast cancer, 250 identified cases were further followed up from the date of diagnosis to 2008, and 45 all-cause deaths were documented. Study subjects were categorized into four groups based on the quartile points of scores ranging between 0 and 12 on each EPQ-R subscale (extraversion, neuroticism, psychoticism, and lie), and the hazard ratio (HR) for each category was computed using the lowest category as reference. Multivariate analysis revealed no association between any of the four personality subscales and the risk of breast cancer. In the analysis on survival, no significant association was found between any of these subscales and the risk of death, although breast cancer cases with a higher score of extraversion tended to have a lower risk of death (P for trend = 0.07; HR for highest score level = 0.38). Exclusion of 32 cases diagnosed in the first 3 years of follow-up did not largely change the results with regard to either breast cancer risk or survival. The present findings suggest that personality does not impact significantly on the development and progression of breast cancer.

Keywords

Breast cancer Cohort study Personality Risk Survival Eysenck Personality Questionnaire-Revised 

Notes

Acknowledgments

This work was supported by Grant-in-Aid from the Japan Society for the Promotion of Science (JSPS) for Scientific Research (B) (23390169).

Conflict of interest

The authors have no conflicts of interest to declare.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Yuko Minami
    • 1
  • Toru Hosokawa
    • 2
  • Naoki Nakaya
    • 3
  • Yumi Sugawara
    • 4
  • Yoshikazu Nishino
    • 5
  • Yoichiro Kakugawa
    • 6
  • Akira Fukao
    • 7
  • Ichiro Tsuji
    • 4
  1. 1.Division of Community HealthTohoku University Graduate School of MedicineSendaiJapan
  2. 2.Department of Human Development and DisabilitiesTohoku University Graduate School of EducationSendaiJapan
  3. 3.Department of Preventive Medicine and EpidemiologyTohoku Medical Megabank Organization, Tohoku UniversitySendaiJapan
  4. 4.Division of Epidemiology, Department of Public Health and Forensic MedicineTohoku University Graduate School of MedicineSendaiJapan
  5. 5.Division of Cancer Epidemiology and PreventionMiyagi Cancer Center Research InstituteNatoriJapan
  6. 6.Department of Breast OncologyMiyagi Cancer Center HospitalNatoriJapan
  7. 7.Department of Public HealthYamagata University Graduate School of Medical ScienceYamagataJapan

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